PMID- 27460703
OWN - NLM
STAT- MEDLINE
DCOM- 20190329
LR  - 20220318
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1862
IP  - 10
DP  - 2016 Oct
TI  - Basement membrane protein ladinin-1 and the MIF-CD44-beta1 integrin signaling axis 
      are implicated in laryngeal cancer metastasis.
PG  - 1938-54
LID - S0925-4439(16)30182-X [pii]
LID - 10.1016/j.bbadis.2016.07.014 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is the most common form of malignant 
      disease in the head and neck region characterized by frequent occurrence of 
      metastases in the neck lymph nodes early in the disease onset. In the presented 
      study, we performed quantitative proteomic profiling of patient-matched primary 
      tumor and adjacent non-tumorous tissues derived from metastatic LSCC as to 
      identify new protein candidates with potential diagnostic and therapeutic 
      significance. Obtained results revealed for the first time involvement of the 
      basement membrane protein ladinin-1 in laryngeal cancer metastases. Alterations 
      in the cellular microenvironment that propel metastatic events in laryngeal 
      cancer include activation of MIF-CD44-beta1 integrin signal transduction pathway and 
      induction of downstream signaling mediated by NF-kappaB and Src tyrosine kinase, 
      which ultimately impinge on cytoskeletal dynamics and architecture resulting in 
      increased cellular motility and invasiveness. In this context, particularly 
      interesting finding is upregulation of several actin-binding proteins novel to 
      laryngeal cancer pathogenesis including coronin-1C and plastin-2, whose 
      functional significance in laryngeal carcinogenesis has yet to be established. We 
      also detected for the first time a complete loss of afamin in metastatic 
      laryngeal cancer tissues, which warrants further studies into its use as a 
      possible marker for monitoring disease progression and/or treatment outcome.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Klobucar, Marko
AU  - Klobucar M
AD  - University of Rijeka, Department of Biotechnology, Centre for High-throughput 
      Technologies, Radmile Matejcic 2, 51000 Rijeka, Croatia.
FAU - Sedic, Mirela
AU  - Sedic M
AD  - University of Rijeka, Department of Biotechnology, Centre for High-throughput 
      Technologies, Radmile Matejcic 2, 51000 Rijeka, Croatia.
FAU - Gehrig, Peter
AU  - Gehrig P
AD  - Functional Genomics Center Zurich, University of Zurich/ETH Zurich, 
      Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
FAU - Grossmann, Jonas
AU  - Grossmann J
AD  - Functional Genomics Center Zurich, University of Zurich/ETH Zurich, 
      Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
FAU - Bilic, Mario
AU  - Bilic M
AD  - University Department of ENT, Head and Neck Surgery, Kispaticeva 12, 10000 
      Zagreb, Croatia.
FAU - Kovac-Bilic, Lana
AU  - Kovac-Bilic L
AD  - University Department of ENT, Head and Neck Surgery, Kispaticeva 12, 10000 
      Zagreb, Croatia.
FAU - Pavelic, Kresimir
AU  - Pavelic K
AD  - University of Rijeka, Department of Biotechnology, Centre for High-throughput 
      Technologies, Radmile Matejcic 2, 51000 Rijeka, Croatia.
FAU - Kraljevic Pavelic, Sandra
AU  - Kraljevic Pavelic S
AD  - University of Rijeka, Department of Biotechnology, Centre for High-throughput 
      Technologies, Radmile Matejcic 2, 51000 Rijeka, Croatia. Electronic address: 
      sandrakp@biotech.uniri.hr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160725
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD44 protein, human)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Integrin beta1)
RN  - 0 (Macrophage Migration-Inhibitory Factors)
RN  - 0 (Neoplasm Proteins)
RN  - EC 5.3.- (Intramolecular Oxidoreductases)
RN  - EC 5.3.2.1 (MIF protein, human)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/genetics/*metabolism
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Hyaluronan Receptors/genetics/*metabolism
MH  - Integrin beta1/genetics/*metabolism
MH  - Intramolecular Oxidoreductases/genetics/*metabolism
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - Macrophage Migration-Inhibitory Factors/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - *Signal Transduction
MH  - *Tumor Microenvironment
OTO - NOTNLM
OT  - Cytoskeleton
OT  - Ladinin-1
OT  - Metastases
OT  - Proteomics
OT  - Squamous larynx cancer
OT  - Src tyrosine kinase
EDAT- 2016/07/28 06:00
MHDA- 2019/03/30 06:00
CRDT- 2016/07/28 06:00
PHST- 2016/04/21 00:00 [received]
PHST- 2016/07/06 00:00 [revised]
PHST- 2016/07/22 00:00 [accepted]
PHST- 2016/07/28 06:00 [entrez]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2019/03/30 06:00 [medline]
AID - S0925-4439(16)30182-X [pii]
AID - 10.1016/j.bbadis.2016.07.014 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2016 Oct;1862(10):1938-54. doi: 
      10.1016/j.bbadis.2016.07.014. Epub 2016 Jul 25.