PMID- 27460731
OWN - NLM
STAT- MEDLINE
DCOM- 20170726
LR  - 20220316
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 20
IP  - 14
DP  - 2016 Jul
TI  - Over-expression of lncRNA SBF2-AS1 is associated with advanced tumor progression 
      and poor prognosis in patients with non-small cell lung cancer.
PG  - 3031-4
LID - 11174 [pii]
AB  - OBJECTIVE: Emerging evidence suggest that long non-coding RNAs (lncRNAs) may play 
      important roles in human cancers. The aim of this study was to investigate the 
      expression of SBF2-AS1 in non small cell lung cancer (NSCLC) and its correlation 
      with clinicopathological features and prognosis in NSCLC. PATIENTS AND METHODS: 
      The expression of lncRNA SBF2-AS1 was measured in 174 NSCLC samples and their 
      matched non-tumor tissues by using RT-PCR. Association of SBF2-AS1 expression 
      with clinicopathological features was analyzed in NSCLC. Kaplan-Meier analysis 
      was performed to evaluate the overall survival of NSCLC patients. RESULTS: The 
      expression of SBF2-AS1 was higher in NSCLC tissues compared with adjacent 
      non-tumor tissues (p < 0.01). Additionally, high expression level of SBF2-AS1 was 
      significantly associated with NSCLC histological grade, and lymph node 
      metastasis. Furthermore, a higher SBF2-AS1 expression was demonstrated to be 
      associated with poor overall survival times in NSCLC patients (p < 0.001). 
      Multivariate analysis suggested that SBF2-AS1 expression was an independent 
      prognostic factor for overall survival of patients with NSCLC (p = 0.013). 
      CONCLUSIONS: Our data suggest that SBF2-AS1 could represent a novel prognostic 
      marker and potential therapeutic target in patients with NSCLC.
FAU - Zhao, Q-S
AU  - Zhao QS
AD  - Department of Surgery, Linyi People's Hospital, Linyi, Shandong, China. 
      zzxmpl7@126.com.
FAU - Li, L
AU  - Li L
FAU - Zhang, L
AU  - Zhang L
FAU - Meng, X-W
AU  - Meng XW
FAU - Li, L-L
AU  - Li LL
FAU - Ge, X-F
AU  - Ge XF
FAU - Li, Z-P
AU  - Li ZP
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (long non-coding RNA SBF2-AS1, human)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*genetics/pathology
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics
EDAT- 2016/07/28 06:00
MHDA- 2017/07/27 06:00
CRDT- 2016/07/28 06:00
PHST- 2016/07/28 06:00 [entrez]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/07/27 06:00 [medline]
AID - 11174 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2016 Jul;20(14):3031-4.