PMID- 27462869
OWN - NLM
STAT- MEDLINE
DCOM- 20180129
LR  - 20181113
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 33
DP  - 2016 Aug 16
TI  - Volumetric modulated arc therapy for thoracic node metastases: a safe and 
      effective treatment for a neglected disease.
PG  - 53321-53329
LID - 10.18632/oncotarget.10826 [doi]
AB  - PURPOSE: To evaluate the outcome of Stereotactic Body Radiation Therapy (SBRT) 
      with Volumetric Modulated Arc Therapy (VMAT) for thoracic node metastases. 
      RESULTS: 18 out of 29 patients presented with isolated thoracic node metastases 
      with no other sites of disease. Median prescribed dose was 45Gy (range 
      30-60Gy).Acute toxicity was recorded as G0 in 28 patients, while one patient was 
      scored as G1. Late toxicity was G0 in 26 patients, one patient was scored G1, one 
      as G2, and one as G4 presented acute myocardial infarction.During follow up, the 
      best local response was complete remission in 14 patients and partial remission 
      in 11 patients. With a median follow up of 12 months (range 2-35) 9 patients died 
      from disease progression, 10 were still alive with distant metastases, 5 had a 
      locally controlled disease and 5 patients were disease free.The median OS 
      estimated was 18 months (76%, 49% at one, two years). The median PFS was 9 months 
      (28%, 17% at one, two years). MATERIALS AND METHODS: Twenty-nine patients with 32 
      thoracic nodes metastases were treated with SBRT in our institution. Toxicities 
      and response were assessed. Overall Survival (OS) and Progression Free Survival 
      (PFS) were evaluated. CONCLUSIONS: SBRT is an efficient treatment for thoracic 
      node metastases.
FAU - Franceschini, Davide
AU  - Franceschini D
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - De Rose, Fiorenza
AU  - De Rose F
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Fogliata, Antonella
AU  - Fogliata A
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Navarria, Piera
AU  - Navarria P
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Ascolese, Anna Maria
AU  - Ascolese AM
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Franzese, Ciro
AU  - Franzese C
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Comito, Tiziana
AU  - Comito T
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Tozzi, Angelo
AU  - Tozzi A
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Iftode, Cristina
AU  - Iftode C
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Di Brina, Lucia
AU  - Di Brina L
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - D'Agostino, Giuseppe
AU  - D'Agostino G
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Clerici, Elena
AU  - Clerici E
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
FAU - Cozzi, Luca
AU  - Cozzi L
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, 20089 Milan-Rozzano, 
      Italy.
FAU - Scorsetti, Marta
AU  - Scorsetti M
AD  - Humanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy 
      Department, 20089 Milan-Rozzano, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, 20089 Milan-Rozzano, 
      Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lymph Nodes/pathology/*radiation effects
MH  - Lymphatic Metastasis/*radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Neglected Diseases/*radiotherapy
MH  - Pneumonia/etiology
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Intensity-Modulated/adverse effects/*methods
MH  - Retrospective Studies
MH  - Thorax/pathology/*radiation effects
MH  - Young Adult
PMC - PMC5288189
OTO - NOTNLM
OT  - SBRT
OT  - mediastinal nodes
OT  - oligometastases
COIS- L. Cozzi acts as Scientific Advisor to Varian Medical Systems and is Clinical 
      Research Scientist at Humanitas Cancer Center. All other co-authors have no 
      competing interests.
EDAT- 2016/07/28 06:00
MHDA- 2018/01/30 06:00
PMCR- 2016/08/16
CRDT- 2016/07/28 06:00
PHST- 2016/03/21 00:00 [received]
PHST- 2016/06/30 00:00 [accepted]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2018/01/30 06:00 [medline]
PHST- 2016/07/28 06:00 [entrez]
PHST- 2016/08/16 00:00 [pmc-release]
AID - 10826 [pii]
AID - 10.18632/oncotarget.10826 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Aug 16;7(33):53321-53329. doi: 10.18632/oncotarget.10826.