PMID- 2746314
OWN - NLM
STAT- MEDLINE
DCOM- 19890825
LR  - 20171213
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 61
IP  - 6
DP  - 1989 Jun
TI  - Patterns of resting discharge in neurons of the raccoon main cuneate nucleus.
PG  - 1131-41
AB  - 1. The presence and pattern of resting discharge were examined in 100 single 
      neurons of the raccoon main cuneate nucleus (MCN). Of these, 66 were activated, 
      either antidromically or synaptically, by electrical stimulation of the 
      contralateral thalamic ventrobasal complex (VB), and 34 were activated by 
      stimulation of the ipsilateral cerebellum (CB). 2. Forty-one percent of 
      VB-activated neurons displayed a resting discharge, whereas 32% of CB-activated 
      neurons did. Most neurons activated from VB and showing a resting discharge fired 
      in bursts of 2-5 spikes, whereas those activated from CB and showing a resting 
      discharge generally fired as single, irregularly spaced spikes, with occasional 
      bursts in some neurons. 3. All neurons antidromically activated from VB were 
      histologically localized within the clusters region of the MCN, whereas those 
      antidromically activated from CB were confined to its polymorphic region. Neurons 
      synaptically activated from either VB or CB were located in either of these 
      regions. 4. Differences in the proportions of neurons displaying a resting 
      discharge did not vary significantly as a function of type of preparation: 
      methoxyflurane anesthesia, pentobarbital sodium anesthesia, decerebrate (the 
      latter CB-activated only). 5. Although the sample sizes were too small to 
      demonstrate statistical significance, neurons exhibiting a resting discharge were 
      more likely to show a bursting pattern in methoxyflurane-anesthetized 
      preparations than were neurons in pentobarbital sodium-anesthetized preparations. 
      6. The probability of having no resting discharge, firing in bursts, or firing in 
      single spikes was not related to cutaneous submodality [rapidly adapting (RA), 
      slowly adapting (SA), Pacinian (Pc)], or to receptive field (RF) locus (glabrous 
      versus hairy skin). 7. The overall mean rate of firing (11.8 Hz) was not 
      significantly different for bursting versus nonbursting neurons. 8. In bursting 
      neurons, median interspike intervals (ISIs) varied between 1.3 and 2.3 ms. Most 
      bursting neurons also had a range of short or minimal interburst intervals 
      (MIBIs), characteristic for each neuron, whose medians varied from neuron to 
      neuron between 34 and 90 ms. Distributions of within-burst ISIs and MIBIs had 
      comparable coefficients of variation, varying between 0.031 and 0.223. 9. The 
      application of a mechanical stimulus to a neuron's peripheral RF led to a 
      decrease in interburst intervals, accompanied, depending upon the unit, by either 
      an increase or a decrease in the number of spikes per burst. 10. Results are 
      discussed in terms of the functional significance of resting discharge, including 
      bursting, and possible roles in somatosensory information
FAU - Pubols, B H Jr
AU  - Pubols BH Jr
AD  - Neurological Sciences Institute, Good Samaritan Hospital and Medical Center, 
      Portland, Oregon 97209.
FAU - Haring, J H
AU  - Haring JH
FAU - Rowinski, M J
AU  - Rowinski MJ
LA  - eng
GR  - NS-13418/NS/NINDS NIH HHS/United States
GR  - NS-19486/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Animals
MH  - Cerebellum/physiology
MH  - Electric Stimulation
MH  - Female
MH  - Male
MH  - Medulla Oblongata/*physiology
MH  - Membrane Potentials
MH  - Neurons/*physiology
MH  - Raccoons
MH  - Thalamus/physiology
EDAT- 1989/06/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
AID - 10.1152/jn.1989.61.6.1131 [doi]
PST - ppublish
SO  - J Neurophysiol. 1989 Jun;61(6):1131-41. doi: 10.1152/jn.1989.61.6.1131.