PMID- 27465434
OWN - NLM
STAT- MEDLINE
DCOM- 20180425
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Jul 28
TI  - Short-term moderate diet restriction in adulthood can reverse oxidative, 
      cardiovascular and metabolic alterations induced by postnatal overfeeding in 
      mice.
PG  - 30817
LID - 10.1038/srep30817 [doi]
LID - 30817
AB  - We aimed to determine whether moderate diet restriction could restore cardiac, 
      oxidative and metabolic alterations induced by postnatal overfeeding (PNOF). 
      Litters of C57BL/6 male mice were either maintained at 9 (normal litter, NL), or 
      reduced to 3 (small litter, SL) in order to induce PNOF. At 6 months, half of the 
      NL and SL mice were subjected to 20% calorie-restriction (CR: NLCR, SLCR) for one 
      month, while the other half continued to eat ad libitum (AL: NLAL, SLAL). 
      Six-month old SL mice presented overweight, fat accumulation, hyperleptinemia, 
      glucose intolerance, insulin resistance, increased cardiac ROS production and 
      decreased left ventricular ejection fraction (LVEF). After CR, SL mice body 
      weight was normalized; however, their fat mass and leptinemia were not decreased, 
      glucose metabolism was improved and LVEF was increased. In SL mice, CR increased 
      the cardiac mitochondrial respiratory rate and decreased cardiac ROS production. 
      Hearts from SLCR mice showed better recovery and smaller postischemic infarct 
      size. Intriguingly, no difference was observed between NLAL and NLCR mice for 
      most of the parameters investigated. Short-term moderate CR not only normalized 
      body weight in SL mice but also improved metabolic programming and reversed 
      oxidative and cardiac dysfunction induced by PNOF.
FAU - Li, Na
AU  - Li N
AD  - Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie 
      Cardio-Metaboliques (LPPCM), Universite de Bourgogne Franche-Comte, Dijon, 
      France.
FAU - Guenancia, Charles
AU  - Guenancia C
AD  - Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie 
      Cardio-Metaboliques (LPPCM), Universite de Bourgogne Franche-Comte, Dijon, 
      France.
AD  - Service de Cardiologie, Centre Hospitalier Universitaire, Dijon, France.
FAU - Rigal, Eve
AU  - Rigal E
AD  - Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie 
      Cardio-Metaboliques (LPPCM), Universite de Bourgogne Franche-Comte, Dijon, 
      France.
FAU - Hachet, Olivier
AU  - Hachet O
AD  - Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie 
      Cardio-Metaboliques (LPPCM), Universite de Bourgogne Franche-Comte, Dijon, 
      France.
FAU - Chollet, Pauline
AU  - Chollet P
AD  - Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie 
      Cardio-Metaboliques (LPPCM), Universite de Bourgogne Franche-Comte, Dijon, 
      France.
FAU - Desmoulins, Lucie
AU  - Desmoulins L
AD  - CNRS UMR 6265, Centre des Sciences du Gout de l'Alimentation, Dijon, France.
AD  - INRA UMR 1324, Centre des Sciences du Gout de l'Alimentation, Dijon, France.
AD  - Univ. Bourgogne Franche-Comte, UMR Centre des Sciences du Gout de l'Alimentation 
      Dijon, France.
FAU - Leloup, Corinne
AU  - Leloup C
AD  - CNRS UMR 6265, Centre des Sciences du Gout de l'Alimentation, Dijon, France.
AD  - INRA UMR 1324, Centre des Sciences du Gout de l'Alimentation, Dijon, France.
AD  - Univ. Bourgogne Franche-Comte, UMR Centre des Sciences du Gout de l'Alimentation 
      Dijon, France.
FAU - Rochette, Luc
AU  - Rochette L
AD  - Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie 
      Cardio-Metaboliques (LPPCM), Universite de Bourgogne Franche-Comte, Dijon, 
      France.
FAU - Vergely, Catherine
AU  - Vergely C
AD  - Inserm UMR866, Laboratoire de Physiopathologie et Pharmacologie 
      Cardio-Metaboliques (LPPCM), Universite de Bourgogne Franche-Comte, Dijon, 
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160728
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Body Composition
MH  - Body Weight
MH  - Caloric Restriction/*methods
MH  - Insulin Resistance
MH  - Litter Size
MH  - Male
MH  - Metabolic Diseases/*diet therapy
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mitochondria, Heart/drug effects/*physiology
MH  - Oxidative Stress/drug effects
PMC - PMC4964358
EDAT- 2016/07/29 06:00
MHDA- 2018/04/26 06:00
PMCR- 2016/07/28
CRDT- 2016/07/29 06:00
PHST- 2016/04/01 00:00 [received]
PHST- 2016/07/11 00:00 [accepted]
PHST- 2016/07/29 06:00 [entrez]
PHST- 2016/07/29 06:00 [pubmed]
PHST- 2018/04/26 06:00 [medline]
PHST- 2016/07/28 00:00 [pmc-release]
AID - srep30817 [pii]
AID - 10.1038/srep30817 [doi]
PST - epublish
SO  - Sci Rep. 2016 Jul 28;6:30817. doi: 10.1038/srep30817.