PMID- 27465737
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20200930
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Linking)
VI  - 311
IP  - 4
DP  - 2016 Oct 1
TI  - Ceramides are involved in the regulation of food intake in rainbow trout 
      (Oncorhynchus mykiss).
PG  - R658-R668
LID - 10.1152/ajpregu.00201.2016 [doi]
AB  - We hypothesize that ceramides are involved in the regulation of food intake in 
      fish. Therefore, we assessed in rainbow trout (Oncorhynchus mykiss) the effects 
      of intracerebroventricular treatment with C6:0 ceramide on food intake. In a 
      second experiment, we assessed the effects in brain areas of ceramide treatment 
      on neuropeptide expression, fatty acid-sensing systems, and cellular signaling 
      pathways. Ceramide treatment induced a decrease in food intake, a response 
      opposed to the orexigenic effect described in mammals, which can be related to 
      enhanced mRNA abundance of cocaine and amphetamine-related transcript and 
      proopiomelanocortin and decreased mRNA abundance of Agouti-related protein and 
      neuropeptide Y. Fatty acid-sensing systems appear to be inactivated by ceramide 
      treatment. The mRNA abundance of integrative sensors AMPK and sirtuin 1, and the 
      phosphorylation status of cellular signaling pathways dependent on protein kinase 
      B, AMPK, mammalian target of rapamycin (mTOR), and forkhead box protein O1 
      (FoxO1) are generally activated by ceramide treatment. However, there are 
      differences between hypothalamus and hindbrain in the phosphorylation status of 
      AMPK (decreased in hypothalamus and increased in hindbrain), mTOR (decreased in 
      hypothalamus and increased in hindbrain), and FoxO1 (increased in hypothalamus 
      and decreased in hindbrain) to ceramide treatment. The results suggest that 
      ceramides are involved in the regulation of food intake in rainbow trout through 
      mechanisms comparable to those characterized previously in mammals in some cases.
CI  - Copyright (c) 2016 the American Physiological Society.
FAU - Velasco, Cristina
AU  - Velasco C
AD  - Laboratorio de Fisioloxia Animal, Departamento de Bioloxia Funcional e Ciencias 
      da Saude, Facultade de Bioloxia, Universidade de Vigo, Vigo, Spain.
FAU - Libran-Perez, Marta
AU  - Libran-Perez M
AD  - Laboratorio de Fisioloxia Animal, Departamento de Bioloxia Funcional e Ciencias 
      da Saude, Facultade de Bioloxia, Universidade de Vigo, Vigo, Spain.
FAU - Otero-Rodino, Cristina
AU  - Otero-Rodino C
AD  - Laboratorio de Fisioloxia Animal, Departamento de Bioloxia Funcional e Ciencias 
      da Saude, Facultade de Bioloxia, Universidade de Vigo, Vigo, Spain.
FAU - Lopez-Patino, Marcos A
AU  - Lopez-Patino MA
AD  - Laboratorio de Fisioloxia Animal, Departamento de Bioloxia Funcional e Ciencias 
      da Saude, Facultade de Bioloxia, Universidade de Vigo, Vigo, Spain.
FAU - Miguez, Jesus M
AU  - Miguez JM
AD  - Laboratorio de Fisioloxia Animal, Departamento de Bioloxia Funcional e Ciencias 
      da Saude, Facultade de Bioloxia, Universidade de Vigo, Vigo, Spain.
FAU - Soengas, Jose L
AU  - Soengas JL
AUID- ORCID: 0000-0002-6847-3993
AD  - Laboratorio de Fisioloxia Animal, Departamento de Bioloxia Funcional e Ciencias 
      da Saude, Facultade de Bioloxia, Universidade de Vigo, Vigo, Spain 
      jsoengas@uvigo.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160727
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Ceramides)
SB  - IM
MH  - Animals
MH  - Appetite/*physiology
MH  - Appetite Regulation/*physiology
MH  - Brain/*metabolism
MH  - Ceramides/*metabolism
MH  - Eating/*physiology
MH  - Oncorhynchus mykiss/*physiology
OTO - NOTNLM
OT  - ceramide
OT  - food intake
OT  - hindbrain
OT  - hypothalamus
OT  - lipid
OT  - rainbow trout
EDAT- 2016/07/29 06:00
MHDA- 2017/06/27 06:00
CRDT- 2016/07/29 06:00
PHST- 2016/05/18 00:00 [received]
PHST- 2016/07/27 00:00 [accepted]
PHST- 2016/07/29 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2016/07/29 06:00 [entrez]
AID - ajpregu.00201.2016 [pii]
AID - 10.1152/ajpregu.00201.2016 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311(4):R658-R668. doi: 
      10.1152/ajpregu.00201.2016. Epub 2016 Jul 27.