PMID- 27467284
OWN - NLM
STAT- MEDLINE
DCOM- 20170518
LR  - 20181113
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 17
IP  - 6
DP  - 2016 Sep
TI  - Specific HLA genotypes confer susceptibility to acute necrotizing encephalopathy.
PG  - 367-9
LID - 10.1038/gene.2016.32 [doi]
AB  - Acute necrotizing encephalopathy (ANE) is a rare and severe syndrome of acute 
      encephalopathy triggered by viral infections. Cytokine storm is considered as the 
      main pathogenetic mechanism of ANE. ANE is prevalent in East Asia, suggesting the 
      association of host genetic factors. To elucidate the genetic background of 
      Japanese ANE, we examined genotypes of human leukocyte antigen (HLA)-A, C, B, 
      DRB1, DQB1 and DPB1 in 31 patients. Significant positive association was observed 
      in both the allele frequency and positivity of DRB1*09:01 (P=0.043 and 0.025, 
      respectively), as well as those of DQB1*03:03 (P=0.034 and 0.026, respectively). 
      The carrier frequency of DRB1*09:01 and DQB1*03:03 alleles was higher in the 
      patients (45.16%) than in controls (28.57%). These alleles are more common in 
      East Asian than in European populations, and are reportedly associated with 
      various autoimmune diseases in Japanese patients. Our data provide further 
      evidence that altered immune response based on individual HLA genotypes may 
      contribute to ANE pathogenesis.
FAU - Hoshino, A
AU  - Hoshino A
AD  - Department of Developmental Medical Sciences, Graduate School of Medicine, The 
      University of Tokyo, Tokyo, Japan.
AD  - Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 
      Tokyo, Japan.
FAU - Saitoh, M
AU  - Saitoh M
AD  - Department of Developmental Medical Sciences, Graduate School of Medicine, The 
      University of Tokyo, Tokyo, Japan.
FAU - Miyagawa, T
AU  - Miyagawa T
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
AD  - Sleep Disorders Project, Department of Psychiatry and Behavioral Sciences, Tokyo 
      Metropolitan Institute of Medical Science, Tokyo, Japan.
FAU - Kubota, M
AU  - Kubota M
AD  - Division of Neurology, National Center for Child Health and Development, Tokyo, 
      Japan.
FAU - Takanashi, J-I
AU  - Takanashi JI
AD  - Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Yachiyo, Japan.
FAU - Miyamoto, A
AU  - Miyamoto A
AD  - Department of Pediatrics, Asahikawa Habilitation Center for Disabled Children, 
      Asahikawa, Japan.
FAU - Tokunaga, K
AU  - Tokunaga K
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Oka, A
AU  - Oka A
AD  - Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 
      Tokyo, Japan.
FAU - Mizuguchi, M
AU  - Mizuguchi M
AD  - Department of Developmental Medical Sciences, Graduate School of Medicine, The 
      University of Tokyo, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160728
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Disease Susceptibility
MH  - Encephalitis, Viral/*genetics/pathology
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Leukoencephalitis, Acute Hemorrhagic/*genetics
EDAT- 2016/07/29 06:00
MHDA- 2017/05/19 06:00
CRDT- 2016/07/29 06:00
PHST- 2016/05/19 00:00 [received]
PHST- 2016/06/21 00:00 [revised]
PHST- 2016/06/23 00:00 [accepted]
PHST- 2016/07/29 06:00 [entrez]
PHST- 2016/07/29 06:00 [pubmed]
PHST- 2017/05/19 06:00 [medline]
AID - gene201632 [pii]
AID - 10.1038/gene.2016.32 [doi]
PST - ppublish
SO  - Genes Immun. 2016 Sep;17(6):367-9. doi: 10.1038/gene.2016.32. Epub 2016 Jul 28.