PMID- 27467956
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160729
LR  - 20210112
IS  - 2162-4011 (Print)
IS  - 2162-402X (Electronic)
IS  - 2162-4011 (Linking)
VI  - 5
IP  - 5
DP  - 2016 May
TI  - Thymic hyperplasia after chemotherapy in adults with mature B cell lymphoma and 
      its influence on thymic output and CD4(+) T cells repopulation.
PG  - e1137417
LID - 10.1080/2162402X.2015.1137417 [doi]
LID - e1137417
AB  - To investigate the thymic regenerative potential in adults accepting chemotherapy 
      for lymphoma. The dynamics of thymic activity in 54 adults from baseline to 12 mo 
      post-chemotherapy was analyzed by assessing thymic structural changes with serial 
      computed tomography (CT) scans, and correlating these with measurements of thymic 
      output by concurrent analysis of single-joint (sj) T-cell receptor excision 
      circles (sjTREC) and CD31(+) recent thymic emigrants (RTE) in peripheral blood. 
      Furthermore, the consequence of thymic renewal on peripheral CD4(+) T cell 
      recovery after chemotherapy was evaluated. Time-dependent changes of thymic size 
      and thymic output assessed by both sjTREC levels and CD31(+) RTE counts in 
      peripheral blood were observed during and after chemotherapy. Enlargement of 
      thymus over baseline following chemotherapy regarded as rebound thymic 
      hyperplasia (TH) was identified in 20 patients aged 18-53 y (median 33 y). By 
      general linear models repeated measure analysis, it was found that, patients with 
      TH (n = 20) had a faster recovery of sjTREC levels and CD31(+) RTE counts after 
      chemotherapy than patients with comparable age, gender, diagnosis, disease stage, 
      thymic volume and output function at baseline but without TH (n = 18) (p = 0.035, 
      0.047); besides, patients with TH had a faster repopulation of both naive CD4(+) 
      T cell and natural regulatory CD4(+) T cell subsets than those without TH (p = 
      0.042, 0.038). These data suggested that adult thymus retains the capacity of 
      regeneration after chemotherapy, especially in young adults. The presence of TH 
      could contribute to the renewal of thymopoiesis and the replenishment of 
      peripheral CD4(+) T cell pool following chemotherapy in adults.
FAU - Sun, Dao-Ping
AU  - Sun DP
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, Nanjing, China; Department of Hematology, 
      Jining No.1 People's Hospital, Jining, China.
FAU - Jin, Hui
AU  - Jin H
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union 
      Medical College , Tianjin, China.
FAU - Ding, Chong-Yang
AU  - Ding CY
AD  - Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital , Nanjing, China.
FAU - Liang, Jin-Hua
AU  - Liang JH
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital , Nanjing, China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital , Nanjing, China.
FAU - Fan, Lei
AU  - Fan L
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital , Nanjing, China.
FAU - Wu, Yu-Jie
AU  - Wu YJ
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital , Nanjing, China.
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital , Nanjing, China.
FAU - Li, Jian-Yong
AU  - Li JY
AD  - Department of Hematology, the First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital , Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160218
PL  - United States
TA  - Oncoimmunology
JT  - Oncoimmunology
JID - 101570526
PMC - PMC4910735
OTO - NOTNLM
OT  - Adult
OT  - chemotherapy
OT  - recent thymic emigrants
OT  - single-joint T-cell receptor excision circles
OT  - thymic hyperplasia
EDAT- 2016/07/29 06:00
MHDA- 2016/07/29 06:01
PMCR- 2016/02/18
CRDT- 2016/07/29 06:00
PHST- 2015/10/21 00:00 [received]
PHST- 2015/12/16 00:00 [revised]
PHST- 2015/12/28 00:00 [accepted]
PHST- 2016/07/29 06:00 [entrez]
PHST- 2016/07/29 06:00 [pubmed]
PHST- 2016/07/29 06:01 [medline]
PHST- 2016/02/18 00:00 [pmc-release]
AID - 1137417 [pii]
AID - 10.1080/2162402X.2015.1137417 [doi]
PST - epublish
SO  - Oncoimmunology. 2016 Feb 18;5(5):e1137417. doi: 10.1080/2162402X.2015.1137417. 
      eCollection 2016 May.