PMID- 27468356
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160729
LR  - 20200930
IS  - 1226-4601 (Print)
IS  - 2055-7124 (Electronic)
IS  - 1226-4601 (Linking)
VI  - 20
DP  - 2016
TI  - Collagen-grafted porous HDPE/PEAA scaffolds for bone reconstruction.
PG  - 23
LID - 10.1186/s40824-016-0071-5 [doi]
LID - 23
AB  - After tumor resection, bone reconstruction such as skull base reconstruction 
      using interconnected porous structure is absolutely necessary. In this study, 
      porous scaffolds for bone reconstruction were prepared using heat-pressing and 
      salt-leaching methods. High-density polyethylene (HDPE) and 
      poly(ethylene-co-acrylic acid) (PEAA) were chosen as the polymer composites for 
      producing a porous scaffold of high mechanical strength and having high 
      reactivity with biomaterials such as collagen, respectively. The porous structure 
      was observed through surface images, and its intrusion volume and porosity were 
      measured. Owing to the carboxylic acids on PEAA, collagen was successfully 
      grafted onto the porous HDPE/PEAA scaffold, which was confirmed by FT-IR 
      spectroscopy and electron spectroscopy for chemical analysis. Osteoblasts were 
      cultured on the collagen-grafted porous scaffold, and their adhesion, 
      proliferation, and differentiation were investigated. The high viability and 
      growth of the osteoblasts suggest that the collagen-grafted porous HDPE/PEAA is a 
      promising scaffold material for bone generation.
FAU - Kim, Chang-Shik
AU  - Kim CS
AD  - Department of Polymer Science and Engineering, Kyungpook National University, 
      Daegu, 702-701 South Korea.
FAU - Jung, Kyung-Hye
AU  - Jung KH
AD  - Department of Advanced Materials and Chemical Engineering, Catholic University of 
      Daegu, Kyungsan, South Korea.
FAU - Kim, Hun
AU  - Kim H
AD  - Jeil Medical Corporation, Seoul, South Korea.
FAU - Kim, Chan-Bong
AU  - Kim CB
AD  - Jeil Medical Corporation, Seoul, South Korea.
FAU - Kang, Inn-Kyu
AU  - Kang IK
AD  - Department of Polymer Science and Engineering, Kyungpook National University, 
      Daegu, 702-701 South Korea.
LA  - eng
PT  - Journal Article
DEP - 20160727
PL  - United States
TA  - Biomater Res
JT  - Biomaterials research
JID - 101650636
PMC - PMC4962353
OTO - NOTNLM
OT  - Collagen
OT  - Differentiation
OT  - High-density polyethylene
OT  - Osteoblasts
OT  - Porous scaffolds
EDAT- 2016/07/29 06:00
MHDA- 2016/07/29 06:01
PMCR- 2016/07/27
CRDT- 2016/07/29 06:00
PHST- 2016/04/29 00:00 [received]
PHST- 2016/07/19 00:00 [accepted]
PHST- 2016/07/29 06:00 [entrez]
PHST- 2016/07/29 06:00 [pubmed]
PHST- 2016/07/29 06:01 [medline]
PHST- 2016/07/27 00:00 [pmc-release]
AID - 71 [pii]
AID - 10.1186/s40824-016-0071-5 [doi]
PST - epublish
SO  - Biomater Res. 2016 Jul 27;20:23. doi: 10.1186/s40824-016-0071-5. eCollection 
      2016.