PMID- 27468747
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20181113
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 65
IP  - 11
DP  - 2016 Nov
TI  - Insulin-Like Growth Factor Axis and Gestational Diabetes Mellitus: A Longitudinal 
      Study in a Multiracial Cohort.
PG  - 3495-3504
AB  - The insulin-like growth factor (IGF) axis may be implicated in glucose 
      homeostasis, but its longitudinal profile across gestation in relation to the 
      development of gestational diabetes mellitus (GDM) is largely unknown. We 
      prospectively investigated IGF axis biomarkers in early-to-midpregnancy in 
      relation to subsequent GDM risk in a case-control study of 107 case subjects with 
      GDM and 214 control subjects without GDM, with blood sample collection at 
      gestational weeks 10-14, 15-26, 23-31, and 33-39. Conditional logistic regression 
      was used, adjusting for major risk factors including prepregnancy BMI. Plasma 
      IGF-I and IGF binding protein 3 (IGFBP-3) concentrations and molar ratio of IGF-I 
      to IGFBP-3 increased, whereas IGFBP-2 decreased throughout pregnancy. At 
      gestational weeks 10-14, both IGF-I and IGF-I/IGFBP-3 were positively associated 
      with GDM risk; adjusted odds ratio (OR) comparing the highest versus lowest 
      quartile (OR(Q4-Q1)) was 2.93 (95% CI 1.18, 7.30) for IGF-I and 3.31 (1.10, 9.98) 
      for IGF-I/IGFBP-3. In contrast, higher IGFBP-2 levels were related to a 
      substantially lower risk of GDM (OR(Q4-Q1) 0.04 [0.01, 0.06]). Similar results 
      were observed at gestational weeks 15-26. In sum, the IGF axis, IGFBP-2 in 
      particular, may be implicated in the pathogenesis of GDM, with significant 
      associations and incremental predictive value detected as early as gestational 
      weeks 10-14,  approximately 10-18 weeks earlier before GDM is typically screened for.
CI  - (c) 2016 by the American Diabetes Association.
FAU - Zhu, Yeyi
AU  - Zhu Y
AD  - Epidemiology Branch, Division of Intramural Population Health Research, Eunice 
      Kennedy Shriver National Institute of Child Health and Human Development, 
      Rockville, MD.
FAU - Mendola, Pauline
AU  - Mendola P
AD  - Epidemiology Branch, Division of Intramural Population Health Research, Eunice 
      Kennedy Shriver National Institute of Child Health and Human Development, 
      Rockville, MD.
FAU - Albert, Paul S
AU  - Albert PS
AD  - Biostatistics and Bioinformatics Branch, Division of Intramural Population Health 
      Research, Eunice Kennedy Shriver National Institute of Child Health and Human 
      Development, Rockville, MD.
FAU - Bao, Wei
AU  - Bao W
AD  - Department of Epidemiology, University of Iowa, Iowa City, IA.
FAU - Hinkle, Stefanie N
AU  - Hinkle SN
AD  - Epidemiology Branch, Division of Intramural Population Health Research, Eunice 
      Kennedy Shriver National Institute of Child Health and Human Development, 
      Rockville, MD.
FAU - Tsai, Michael Y
AU  - Tsai MY
AD  - Department of Laboratory Medicine and Pathology, University of Minnesota, 
      Minneapolis, MN.
FAU - Zhang, Cuilin
AU  - Zhang C
AD  - Epidemiology Branch, Division of Intramural Population Health Research, Eunice 
      Kennedy Shriver National Institute of Child Health and Human Development, 
      Rockville, MD zhangcu@mail.nih.gov.
LA  - eng
GR  - HHSN275201000001Z/HD/NICHD NIH HHS/United States
GR  - HHSN275200800003C/HD/NICHD NIH HHS/United States
GR  - HHSN275201000009C/HD/NICHD NIH HHS/United States
GR  - HHSN275200800014C/HD/NICHD NIH HHS/United States
GR  - HHSN275200800002I/HD/NICHD NIH HHS/United States
GR  - HHSN275200800028C/HD/NICHD NIH HHS/United States
GR  - HHSN275200800002C/HD/NICHD NIH HHS/United States
GR  - HHSN275200800013C/HD/NICHD NIH HHS/United States
GR  - HHSN275200800012C/HD/NICHD NIH HHS/United States
GR  - HHSN275200800003I/HD/NICHD NIH HHS/United States
GR  - HHSN275201000001G/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20160728
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Biomarkers)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 1)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 2)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
CIN - Diabetes. 2016 Nov;65(11):3246-3248. PMID: 27959862
MH  - Adult
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Diabetes, Gestational/diagnosis/*metabolism
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 1/*metabolism
MH  - Insulin-Like Growth Factor Binding Protein 2/*metabolism
MH  - Insulin-Like Growth Factor Binding Protein 3/*metabolism
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Longitudinal Studies
MH  - Odds Ratio
MH  - Pregnancy
MH  - Risk Factors
PMC - PMC5079637
EDAT- 2016/07/30 06:00
MHDA- 2017/06/01 06:00
PMCR- 2017/11/01
CRDT- 2016/07/30 06:00
PHST- 2016/04/21 00:00 [received]
PHST- 2016/07/21 00:00 [accepted]
PHST- 2016/07/30 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
PHST- 2016/07/30 06:00 [entrez]
PHST- 2017/11/01 00:00 [pmc-release]
AID - db16-0514 [pii]
AID - 0514 [pii]
AID - 10.2337/db16-0514 [doi]
PST - ppublish
SO  - Diabetes. 2016 Nov;65(11):3495-3504. doi: 10.2337/db16-0514. Epub 2016 Jul 28.