PMID- 27469157
OWN - NLM
STAT- MEDLINE
DCOM- 20170118
LR  - 20181202
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 86 (2016)
IP  - 13
DP  - 2016 Supplement 1
TI  - HIV-associated renal disease - an overview.
PG  - 41-47
AB  - The cause of the human immunodeficiency virus (HIV) epidemic in South Africa (SA) 
      was worsened by the denial by key political players that HIV causes acquired 
      immunodeficiency syndrome (AIDS). South Africa continues to have the highest rate 
      of HIV world-wide, which has had a huge impact on the development of both chronic 
      kidney disease and acute kidney injury. Fortunately, there is now an effective 
      antiretroviral therapy (ART) roll-out program. SA is also dealing with a 
      collision of epidemics of HIV, tuberculosis, and non-communicable disease, 
      particularly hypertension and diabetes. This has been evidenced by recent data 
      seen in the reinstated SA renal registry. There is also an unacceptably high rate 
      of tuberculosis in regions of SA, this has led to high rates of granulomatous 
      interstitial nephritis (GIN) and case reports of TB-GIN immune reconstitution 
      inflammatory syndrome (IRIS). HIV-associated nephropathy (HIVAN) remains common 
      in SA and responds well to ART. The definitive diagnosis requires a renal biopsy, 
      which is often not possible in many regions of sub-Saharan Africa. Unfortunately, 
      there is still a high rate of HIVAN in SA due to late presentation and lack of 
      effective screening for renal disease in HIV-positive patients. Transplantation 
      for HIV-positive donors to positive recipients offers a unique and encouraging 
      way forward for these patients.
FAU - Wearne, Nicola
AU  - Wearne N
FAU - Okpechi, Ikechi G
AU  - Okpechi IG
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
SB  - IM
MH  - AIDS-Associated Nephropathy/*epidemiology/*virology
MH  - *Epidemics
MH  - HIV Infections/*complications
MH  - Humans
MH  - South Africa/epidemiology
MH  - Tuberculosis/complications/epidemiology
EDAT- 2016/07/30 06:00
MHDA- 2017/01/19 06:00
CRDT- 2016/07/30 06:00
PHST- 2016/11/25 00:00 [accepted]
PHST- 2016/07/30 06:00 [pubmed]
PHST- 2017/01/19 06:00 [medline]
PHST- 2016/07/30 06:00 [entrez]
AID - 14637 [pii]
AID - 10.5414/CNP86S117 [doi]
PST - ppublish
SO  - Clin Nephrol. 2016 Supplement 1;86 (2016)(13):41-47. doi: 10.5414/CNP86S117.