PMID- 27470338
OWN - NLM
STAT- MEDLINE
DCOM- 20170207
LR  - 20181202
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 82
DP  - 2016 Aug
TI  - Polydatin induces bone marrow stromal cells migration by activation of ERK1/2.
PG  - 49-53
LID - S0753-3322(16)30316-X [pii]
LID - 10.1016/j.biopha.2016.04.059 [doi]
AB  - Bone marrow stromal cells (BMSCs) have proven to be useful for the treatment of 
      numerous human diseases. However, the reparative ability of BMSCs is limited by 
      their poor migration. Polydatin, widely used in traditional Chinese remedies, has 
      proven to exert protective effects to BMSCs. However, little is known about its 
      role in BMSCs migration. In this study, we studied the effects of polydatin on 
      rat BMSCs migration using the scratch wound healing and transwell migration 
      assays. Our results showed polydatin could promote BMSCs migration. Further 
      experiments showed activation of ERK 1/2, but not JNK, was required for 
      polydatin-induced BMSCs migration, suggesting that polydatin may promote BMSCs 
      migration via the ERK 1/2 signaling pathways. Taken together, our results 
      indicate that polydatin might be beneficial for stem cell replacement therapy by 
      improving BMSCs migration.
CI  - Copyright (c) 2016 Elsevier Masson SAS. All rights reserved.
FAU - Chen, ZhenQiu
AU  - Chen Z
AD  - Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University 
      of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, 
      China; Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of 
      Chinese Medicine, Guangzhou 510405, China.
FAU - Wei, QiuShi
AU  - Wei Q
AD  - Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University 
      of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, 
      China; Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of 
      Chinese Medicine, Guangzhou 510405, China.
FAU - Hong, GuoJu
AU  - Hong G
AD  - Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese 
      Medicine, Guangzhou 510405, China.
FAU - Chen, Da
AU  - Chen D
AD  - Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese 
      Medicine, Guangzhou 510405, China.
FAU - Liang, Jiang
AU  - Liang J
AD  - Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University 
      of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, 
      China.
FAU - He, Wei
AU  - He W
AD  - Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University 
      of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, 
      China; Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of 
      Chinese Medicine, Guangzhou 510405, China. Electronic address: 
      hw13802516062@126.com.
FAU - Chen, Mei Hui
AU  - Chen MH
AD  - Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese 
      Medicine, Guangzhou 510405, China; Guangdong Provincial Acadamy of Chinese 
      Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 
      510120, China. Electronic address: chenmeihuionly@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160506
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Glucosides)
RN  - 0 (Stilbenes)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - XM261C37CQ (polydatin)
SB  - IM
MH  - Animals
MH  - Cell Movement/*drug effects
MH  - Cell Shape/drug effects
MH  - Enzyme Activation/drug effects
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - Glucosides/*pharmacology
MH  - JNK Mitogen-Activated Protein Kinases/metabolism
MH  - Male
MH  - Mesenchymal Stem Cells/*cytology/drug effects/*enzymology
MH  - Phosphorylation/drug effects
MH  - Rats, Sprague-Dawley
MH  - Stilbenes/*pharmacology
OTO - NOTNLM
OT  - BMSCs
OT  - ERK 1/2
OT  - Migration
OT  - Polydatin
EDAT- 2016/07/30 06:00
MHDA- 2017/02/09 06:00
CRDT- 2016/07/30 06:00
PHST- 2016/03/16 00:00 [received]
PHST- 2016/04/27 00:00 [revised]
PHST- 2016/04/27 00:00 [accepted]
PHST- 2016/07/30 06:00 [entrez]
PHST- 2016/07/30 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - S0753-3322(16)30316-X [pii]
AID - 10.1016/j.biopha.2016.04.059 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2016 Aug;82:49-53. doi: 10.1016/j.biopha.2016.04.059. Epub 
      2016 May 6.