PMID- 27471496
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160729
LR  - 20240325
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 7
DP  - 2016
TI  - Dendritic Cells: A Double-Edged Sword in Immune Responses during Chagas Disease.
PG  - 1076
LID - 10.3389/fmicb.2016.01076 [doi]
LID - 1076
AB  - Dendritic cells (DCs) are the most important member of the antigen presenting 
      cells group due to their ability to recognize antigen at the infection site and 
      their high specialized antigen internalization capacity. These cells have central 
      role in connecting the innate and adaptive immune responses against Trypanosoma 
      cruzi, the causative agent of Chagas disease. These first line defense cells 
      modulate host immune response depending on type, maturation level, cytokine 
      milieu and DC receptor involved in the interactions with T. cruzi, influencing 
      the development of the disease clinic forms. Here, we present a review of DCs-T. 
      cruzi interactions both in human and murine models, pointing out the parasite 
      ability to manipulate DCs activity for the purpose of evading innate immune 
      response and assuring its own survival and persistence.
FAU - Gil-Jaramillo, Natalia
AU  - Gil-Jaramillo N
AD  - Laboratorio de Interacao Patogeno-Hospedeiro, Instituto de Biologia, Universidade 
      de Brasilia Brasilia, Brazil.
FAU - Motta, Flavia N
AU  - Motta FN
AD  - Laboratorio de Interacao Patogeno-Hospedeiro, Instituto de Biologia, Universidade 
      de BrasiliaBrasilia, Brazil; Faculdade de Ceilandia, Universidade de 
      BrasiliaBrasilia, Brazil.
FAU - Favali, Cecilia B F
AU  - Favali CB
AD  - Laboratorio de Biologia do Gene, Instituto de Biologia, Universidade de Brasilia 
      Brasilia, Brazil.
FAU - Bastos, Izabela M D
AU  - Bastos IM
AD  - Laboratorio de Interacao Patogeno-Hospedeiro, Instituto de Biologia, Universidade 
      de Brasilia Brasilia, Brazil.
FAU - Santana, Jaime M
AU  - Santana JM
AD  - Laboratorio de Interacao Patogeno-Hospedeiro, Instituto de Biologia, Universidade 
      de Brasilia Brasilia, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160714
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC4943928
OTO - NOTNLM
OT  - Trypanosoma cruzi
OT  - chagas disease
OT  - dendritic cell
OT  - evasion strategy
OT  - immunoregulation
EDAT- 2016/07/30 06:00
MHDA- 2016/07/30 06:01
PMCR- 2016/07/14
CRDT- 2016/07/30 06:00
PHST- 2016/06/01 00:00 [received]
PHST- 2016/06/27 00:00 [accepted]
PHST- 2016/07/30 06:00 [entrez]
PHST- 2016/07/30 06:00 [pubmed]
PHST- 2016/07/30 06:01 [medline]
PHST- 2016/07/14 00:00 [pmc-release]
AID - 10.3389/fmicb.2016.01076 [doi]
PST - epublish
SO  - Front Microbiol. 2016 Jul 14;7:1076. doi: 10.3389/fmicb.2016.01076. eCollection 
      2016.