PMID- 27471609
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160729
LR  - 20220429
IS  - 2162-4011 (Print)
IS  - 2162-402X (Electronic)
IS  - 2162-4011 (Linking)
VI  - 5
IP  - 6
DP  - 2016 Jun
TI  - Tumor relapse prevented by combining adoptive T cell therapy with Salmonella 
      typhimurium.
PG  - e1130207
LID - 10.1080/2162402X.2015.1130207 [doi]
LID - e1130207
AB  - We recently reported that therapeutic vaccination with live tumor 
      antigen-producing Salmonella typhimurium rescues dysfunctional endogenous T cell 
      responses and eradicates long-established tumors refractory to alphaCTLA-4 and alphaPD-L1 
      checkpoint inhibitor blockade. Here, we show that live intravenously injected or 
      heat-killed (HK) intratumorally injected Salmonella typhimurium, even when not 
      producing tumor antigen, synergize with adoptive T cell therapy to eradicate 
      tumors. These data demonstrate that the combination of adoptive T cell transfer 
      with the injection of live or dead Salmonella typhimurium is a promising approach 
      for cancer treatment.
FAU - Binder, David C
AU  - Binder DC
AD  - Committee on Cancer Biology, University of Chicago, Chicago, IL, USA; Department 
      of Pathology, University of Chicago, Chicago, IL, USA.
FAU - Arina, Ainhoa
AU  - Arina A
AD  - Department of Pathology, University of Chicago, Chicago, IL, USA; Committee on 
      Immunology, The University of Chicago, Chicago, IL, USA.
FAU - Wen, Frank
AU  - Wen F
AD  - Department of Pathology, University of Chicago , Chicago, IL, USA.
FAU - Tu, Tony
AU  - Tu T
AD  - Department of Pathology, University of Chicago, Chicago, IL, USA; Committee on 
      Immunology, The University of Chicago, Chicago, IL, USA.
FAU - Zhao, Ming
AU  - Zhao M
AD  - AntiCancer Inc. , San Diego, CA, USA.
FAU - Hoffman, Robert M
AU  - Hoffman RM
AD  - AntiCancer Inc., San Diego, CA, USA; Department of Surgery, University of 
      California, San Diego, CA, USA.
FAU - Wainwright, Derek A
AU  - Wainwright DA
AD  - Department of Neurological Surgery, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA; Northwestern Brain Tumor Institute, Northwestern 
      University Feinberg School of Medicine, Chicago, IL, USA.
FAU - Schreiber, Hans
AU  - Schreiber H
AD  - Committee on Cancer Biology, University of Chicago, Chicago, IL, USA; Department 
      of Pathology, University of Chicago, Chicago, IL, USA; Committee on Immunology, 
      The University of Chicago, Chicago, IL, USA.
LA  - eng
GR  - F32 NS073366/NS/NINDS NIH HHS/United States
GR  - K99 NS082381/NS/NINDS NIH HHS/United States
GR  - P30 CA060553/CA/NCI NIH HHS/United States
GR  - R00 NS082381/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160218
PL  - United States
TA  - Oncoimmunology
JT  - Oncoimmunology
JID - 101570526
PMC - PMC4938310
OTO - NOTNLM
OT  - Adoptive T cell therapy
OT  - bacteria
OT  - macrophage
OT  - relapse
OT  - tumor stroma
EDAT- 2016/07/30 06:00
MHDA- 2016/07/30 06:01
PMCR- 2017/02/18
CRDT- 2016/07/30 06:00
PHST- 2015/10/23 00:00 [received]
PHST- 2015/12/04 00:00 [revised]
PHST- 2015/12/05 00:00 [accepted]
PHST- 2016/07/30 06:00 [entrez]
PHST- 2016/07/30 06:00 [pubmed]
PHST- 2016/07/30 06:01 [medline]
PHST- 2017/02/18 00:00 [pmc-release]
AID - 1130207 [pii]
AID - 10.1080/2162402X.2015.1130207 [doi]
PST - epublish
SO  - Oncoimmunology. 2016 Feb 18;5(6):e1130207. doi: 10.1080/2162402X.2015.1130207. 
      eCollection 2016 Jun.