PMID- 27472929
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20221207
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 36
IP  - 4
DP  - 2017 Aug
TI  - A randomized controlled trial of 130 g/day low-carbohydrate diet in type 2 
      diabetes with poor glycemic control.
PG  - 992-1000
LID - S0261-5614(16)30169-8 [pii]
LID - 10.1016/j.clnu.2016.07.003 [doi]
AB  - BACKGROUND & AIMS: The usefulness of low-carbohydrate diet (LCD) for Japanese 
      patients with type 2 diabetes mellitus (T2DM) has not been fully investigated. 
      Therefore, we compared the effectiveness and safety of LCD with calorie 
      restricted diet (CRD). METHODS: This prospective, randomized, open-label, 
      comparative study included 66 T2DM patients with HbA1c >7.5% even after receiving 
      repeated education programs on CRD. They were randomly allocated to either the 
      130g/day LCD group (n = 33) or CRD group (n = 33). Patients received personal 
      nutrition education of CRD or LCD for 30 min at baseline, 1, 2, 4, and 6 months. 
      Patients of the CRD group were advised to maintain the intake of calories and 
      balance of macronutrients (28x ideal body weight calories per day). Patients of 
      the LCD group were advised to maintain the intake of 130 g/day carbohydrate 
      without other specific restrictions. Several parameters were assessed at baseline 
      and 6 months after each intervention. The primary endpoint was a change in HbA1c 
      level from baseline to the end of the study. RESULTS: At baseline, BMI and HbA1c 
      were 26.5 (24.6-30.1) and 8.3 (8.0-9.3), and 26.7 (25.0-30.0) kg/m(2) and 8.0 
      (7.6-8.9) %, in the CRD and LCD, respectively. At the end of the study, HbA1c 
      decreased by -0.65 (-1.53 to -0.10) % in the LCD group, compared with 0.00 (-0.68 
      to 0.40) % in the CRD group (p < 0.01). Also, the decrease in BMI in the LCD 
      group [-0.58 (-1.51 to -0.16) kg/m(2)] exceeded that observed in the CRD group 
      (p = 0.03). CONCLUSIONS: Our study demonstrated that 6-month 130 g/day LCD 
      reduced HbA1c and BMI in poorly controlled Japanese patients with T2DM. LCD is a 
      potentially useful nutrition therapy for Japanese patients who cannot adhere to 
      CRD. This trial was registered at http://www.umin.ac.jp/english/ (University 
      Hospital Medical Information Network: study ID number 000010663).
CI  - Copyright (c) 2016 Elsevier Ltd and European Society for Clinical Nutrition and 
      Metabolism. All rights reserved.
FAU - Sato, Junko
AU  - Sato J
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Kanazawa, Akio
AU  - Kanazawa A
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo 
      University Graduate School of Medicine, Tokyo, Japan. Electronic address: 
      akana@juntendo.ac.jp.
FAU - Makita, Sumiko
AU  - Makita S
AD  - Department of Nutrition, Juntendo University Hospital, Japan.
FAU - Hatae, Chie
AU  - Hatae C
AD  - Department of Nutrition, Juntendo University Hospital, Japan.
FAU - Komiya, Koji
AU  - Komiya K
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Shimizu, Tomoaki
AU  - Shimizu T
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Ikeda, Fuki
AU  - Ikeda F
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Tamura, Yoshifumi
AU  - Tamura Y
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan; Sportology Center, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Ogihara, Takeshi
AU  - Ogihara T
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Mita, Tomoya
AU  - Mita T
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Goto, Hiromasa
AU  - Goto H
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Uchida, Toyoyoshi
AU  - Uchida T
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Miyatsuka, Takeshi
AU  - Miyatsuka T
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Takeno, Kageumi
AU  - Takeno K
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Shimada, Satoshi
AU  - Shimada S
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Ohmura, Chie
AU  - Ohmura C
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Watanabe, Takehito
AU  - Watanabe T
AD  - Department of Nutrition, Juntendo University Hospital, Japan.
FAU - Kobayashi, Kiyoe
AU  - Kobayashi K
AD  - Department of Nutrition, Juntendo University Hospital, Japan.
FAU - Miura, Yoshiko
AU  - Miura Y
AD  - Department of Nutrition, Juntendo University Hospital, Japan.
FAU - Iwaoka, Manami
AU  - Iwaoka M
AD  - Department of Nutrition, Juntendo University Hospital, Japan.
FAU - Hirashima, Nao
AU  - Hirashima N
AD  - Department of Nutrition, Juntendo University Hospital, Japan.
FAU - Fujitani, Yoshio
AU  - Fujitani Y
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan; Center for Molecular Diabetology, Juntendo University 
      Graduate School of Medicine, Tokyo, Japan.
FAU - Watada, Hirotaka
AU  - Watada H
AD  - Department of Metabolism & Endocrinology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo 
      University Graduate School of Medicine, Tokyo, Japan; Center for Molecular 
      Diabetology, Juntendo University Graduate School of Medicine, Tokyo, Japan; 
      Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
LA  - eng
SI  - UMIN CTR/000010663
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160718
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Aged
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/blood/complications/*diet therapy/ethnology
MH  - *Diet, Carbohydrate-Restricted/ethnology
MH  - *Diet, Diabetic/ethnology
MH  - Diet, Reducing/ethnology
MH  - Energy Intake/ethnology
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hyperglycemia/*prevention & control
MH  - Hypoglycemia/*prevention & control
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Nutritional Sciences/education
MH  - Overweight/blood/complications/diet therapy/ethnology
MH  - *Patient Compliance/ethnology
MH  - Patient Education as Topic
MH  - *Precision Medicine
MH  - Weight Loss/ethnology
OTO - NOTNLM
OT  - Calorie-restricted diet
OT  - Low-carbohydrate diet
OT  - Type 2 diabetes
EDAT- 2016/07/31 06:00
MHDA- 2018/03/27 06:00
CRDT- 2016/07/31 06:00
PHST- 2016/02/17 00:00 [received]
PHST- 2016/07/03 00:00 [revised]
PHST- 2016/07/12 00:00 [accepted]
PHST- 2016/07/31 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2016/07/31 06:00 [entrez]
AID - S0261-5614(16)30169-8 [pii]
AID - 10.1016/j.clnu.2016.07.003 [doi]
PST - ppublish
SO  - Clin Nutr. 2017 Aug;36(4):992-1000. doi: 10.1016/j.clnu.2016.07.003. Epub 2016 
      Jul 18.