PMID- 27473744
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20220331
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 146
IP  - 2
DP  - 2016 Aug
TI  - Successful ABO-Incompatible Renal Transplantation:  Blood Group A1B Donor Into 
      A2B Recipient With Anti-A1 Isoagglutinins.
PG  - 268-71
LID - 10.1093/ajcp/aqw101 [doi]
AB  - OBJECTIVES: Transplantation of the blood group A2B in a recipient was 
      successfully performed in the setting of receiving a deceased donor kidney from 
      an "incompatible" A1B donor. METHODS: The donor and recipient were both typed for 
      ABO blood group, including ABO genotyping. The donor and recipient were tested 
      for ABO, non-ABO, and human leukocyte antigen (HLA) antibodies. The donor and 
      recipient were typed for HLA antigens, including T- and B-flow cytometry 
      crossmatch tests. RESULTS: The recipient's RBCs were negative with A1 lectin, and 
      immunoglobulin G anti-A1 was demonstrated in the recipient's plasma. The 
      donor-recipient pair was a four-antigen HLA mismatch, but final T- and B-flow 
      cytometry crossmatch tests were compatible. The transplant procedure was 
      uneventful; the patient experienced immediate graft function with no episodes of 
      rejection or readmissions more than 2 years later. CONCLUSIONS: It may be safe to 
      transplant across the A1/A2 blood group AB mismatch barrier in the setting of low 
      titer anti-A1 isoagglutinins without the need for pretransplant desensitization 
      even if the antibody produced reacts with anti-human globulin.
CI  - (c) American Society for Clinical Pathology, 2016. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Fadeyi, Emmanuel A
AU  - Fadeyi EA
AD  - From the Departments of Pathology efadeyi@wakehealth.edu.
FAU - Stratta, Robert J
AU  - Stratta RJ
AD  - Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.
FAU - Farney, Alan C
AU  - Farney AC
AD  - Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.
FAU - Pomper, Gregory J
AU  - Pomper GJ
AD  - From the Departments of Pathology.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (ABO Blood-Group System)
SB  - IM
MH  - ABO Blood-Group System/*blood
MH  - Adult
MH  - Blood Group Incompatibility/*blood
MH  - Blood Grouping and Crossmatching
MH  - Female
MH  - Humans
MH  - Kidney Transplantation/*methods
MH  - Male
MH  - Tissue Donors
OTO - NOTNLM
OT  - *ABO incompatible
OT  - *Antibody-mediated rejection
OT  - *HLA mismatch
OT  - *Immunology
OT  - *Renal transplant
OT  - *Special topics
OT  - *Transfusion medicine
EDAT- 2016/07/31 06:00
MHDA- 2017/02/24 06:00
CRDT- 2016/07/31 06:00
PHST- 2016/07/31 06:00 [entrez]
PHST- 2016/07/31 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
AID - aqw101 [pii]
AID - 10.1093/ajcp/aqw101 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2016 Aug;146(2):268-71. doi: 10.1093/ajcp/aqw101.