PMID- 27474171
OWN - NLM
STAT- MEDLINE
DCOM- 20180130
LR  - 20210103
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 37
DP  - 2016 Sep 13
TI  - Microenvironment drug resistance in multiple myeloma: emerging new players.
PG  - 60698-60711
LID - 10.18632/oncotarget.10849 [doi]
AB  - Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process 
      based on a powerful interplay between bone marrow stromal cells and MM cells that 
      allows the latter to escape anti-myeloma therapies. Here we present an overview 
      of the role of the bone marrow microenvironment in both soluble factors-mediated 
      drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR), 
      focusing on the role of new players, namely miRNAs, exosomes and 
      cancer-associated fibroblasts.
FAU - Di Marzo, Lucia
AU  - Di Marzo L
AD  - Department of Biomedical Sciences and Human Oncology, Internal Medicine Section, 
      University of Bari Medical School, Bari, Italy.
FAU - Desantis, Vanessa
AU  - Desantis V
AD  - Department of Biomedical Sciences and Human Oncology, Internal Medicine Section, 
      University of Bari Medical School, Bari, Italy.
FAU - Solimando, Antonio Giovanni
AU  - Solimando AG
AD  - Department of Biomedical Sciences and Human Oncology, Internal Medicine Section, 
      University of Bari Medical School, Bari, Italy.
FAU - Ruggieri, Simona
AU  - Ruggieri S
AD  - Department of Basic Medical Sciences, Neurosciences and Sensory Organs, 
      University of Bari Medical School, Bari, Italy.
FAU - Annese, Tiziana
AU  - Annese T
AD  - Department of Basic Medical Sciences, Neurosciences and Sensory Organs, 
      University of Bari Medical School, Bari, Italy.
FAU - Nico, Beatrice
AU  - Nico B
AD  - Department of Basic Medical Sciences, Neurosciences and Sensory Organs, 
      University of Bari Medical School, Bari, Italy.
FAU - Fumarulo, Ruggiero
AU  - Fumarulo R
AD  - Department of Biomedical Sciences and Human Oncology, General Pathology Section, 
      Bari, Italy.
FAU - Vacca, Angelo
AU  - Vacca A
AD  - Department of Biomedical Sciences and Human Oncology, Internal Medicine Section, 
      University of Bari Medical School, Bari, Italy.
FAU - Frassanito, Maria Antonia
AU  - Frassanito MA
AD  - Department of Biomedical Sciences and Human Oncology, General Pathology Section, 
      Bari, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*physiology
MH  - Cancer-Associated Fibroblasts/*physiology
MH  - Carcinogenesis
MH  - Cell Adhesion
MH  - Drug Resistance, Neoplasm
MH  - Exosomes/metabolism
MH  - Humans
MH  - MicroRNAs/genetics
MH  - Multiple Myeloma/*drug therapy/immunology
MH  - Stromal Cells/*physiology
MH  - Tumor Microenvironment
PMC - PMC5312413
OTO - NOTNLM
OT  - cancer-associated fibroblasts
OT  - drug resistance
OT  - exosomes
OT  - microRNAs
OT  - multiple myeloma
COIS- CONFLICTS OF INTEREST The authors declare no conflict of interest
EDAT- 2016/07/31 06:00
MHDA- 2018/01/31 06:00
PMCR- 2016/09/13
CRDT- 2016/07/31 06:00
PHST- 2016/05/05 00:00 [received]
PHST- 2016/07/11 00:00 [accepted]
PHST- 2016/07/31 06:00 [pubmed]
PHST- 2018/01/31 06:00 [medline]
PHST- 2016/07/31 06:00 [entrez]
PHST- 2016/09/13 00:00 [pmc-release]
AID - 10849 [pii]
AID - 10.18632/oncotarget.10849 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Sep 13;7(37):60698-60711. doi: 10.18632/oncotarget.10849.