PMID- 27476638
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20240325
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 76
IP  - 4
DP  - 2016 Oct
TI  - Inhibition of T-cell activation attenuates hypertension, TNFalpha, IL-17, and 
      blood-brain barrier permeability in pregnant rats with angiogenic imbalance.
PG  - 272-9
LID - 10.1111/aji.12547 [doi]
AB  - PROBLEM: Angiogenic imbalance during pregnancy is associated with immune 
      activation, hypertension, increased T cell infiltration, and neurological 
      insults. METHOD OF STUDY: On gestational day (GD) 12, timed-pregnant rats were 
      infused with anti-angiogenic factors sFlt-1 and sEndoglin (4.7 and 7 mug/kg) to 
      create HELLP syndrome via mini-osmotic pumps for 8 days, with a subset of these 
      rats having Orencia (2 mg/kg) infused on GD13. On GD19, blood-brain barrier (BBB) 
      permeability was evaluated via Evan's Blue infusion, blood was collected for 
      T-cell measurements, inflammatory cytokine secretion. Brain tissues were also 
      collected to examine inflammatory cytokine infiltration. RESULTS: T-cell 
      attenuation with Orencia decreased circulating CD4(+) and CD8(+) T cells, 
      circulating tumor necrosis factor alpha (TNFalpha) and IL-17, BBB permeability and 
      significantly decreased biochemical evidence of HELLP compared to untreated HELLP 
      rats. CONCLUSIONS: These data support the hypothesis that T cells have a critical 
      role in contributing to the pathophysiology that is seen in angiogenic imbalance 
      during pregnancy.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Bean, Cynthia
AU  - Bean C
AD  - Department of Obstetrics & Gynecology, University of Mississippi Medical Center, 
      Jackson, MS, USA.
FAU - Spencer, Shauna-Kay
AU  - Spencer SK
AD  - Department of Obstetrics & Gynecology, University of Mississippi Medical Center, 
      Jackson, MS, USA.
FAU - Bowles, Teylor
AU  - Bowles T
AD  - Department of Obstetrics & Gynecology, University of Mississippi Medical Center, 
      Jackson, MS, USA.
FAU - Kyle, Patrick B
AU  - Kyle PB
AD  - Department of Pathology, University of Mississippi Medical Center, Jackson, MS, 
      USA.
FAU - Williams, Jan M
AU  - Williams JM
AD  - Department of Pharmacology & Toxicology, University of Mississippi Medical 
      Center, Jackson, MS, USA.
FAU - Gibbens, Jacob
AU  - Gibbens J
AD  - Department of Obstetrics & Gynecology, University of Mississippi Medical Center, 
      Jackson, MS, USA.
FAU - Wallace, Kedra
AU  - Wallace K
AD  - Department of Obstetrics & Gynecology, University of Mississippi Medical Center, 
      Jackson, MS, USA. kwallace2@umc.edu.
LA  - eng
GR  - P30 GM103328/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160801
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Endoglin)
RN  - 0 (Eng protein, mouse)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-17)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7D0YB67S97 (Abatacept)
RN  - EC 2.7.10.1 (Flt1 protein, mouse)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
MH  - Abatacept/therapeutic use
MH  - Angiogenesis Inhibitors/administration & dosage
MH  - Animals
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - *Blood-Brain Barrier
MH  - Capillary Permeability
MH  - Disease Models, Animal
MH  - Endoglin/administration & dosage
MH  - Female
MH  - HELLP Syndrome/drug therapy/*immunology
MH  - Humans
MH  - Hypertension
MH  - Inflammation Mediators/metabolism
MH  - Interleukin-17/metabolism
MH  - Lymphocyte Activation
MH  - *Neovascularization, Pathologic
MH  - *Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - T-Lymphocytes/*immunology
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Vascular Endothelial Growth Factor Receptor-1/administration & dosage/immunology
PMC - PMC5023479
MID - NIHMS801649
OTO - NOTNLM
OT  - CD4+ T cells
OT  - HELLP syndrome
OT  - TNFa
OT  - blood-brain barrier
OT  - hypertension, pregnancy brain
EDAT- 2016/08/02 06:00
MHDA- 2017/12/27 06:00
PMCR- 2017/10/01
CRDT- 2016/08/02 06:00
PHST- 2016/03/31 00:00 [received]
PHST- 2016/07/05 00:00 [accepted]
PHST- 2016/08/02 06:00 [entrez]
PHST- 2016/08/02 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - 10.1111/aji.12547 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2016 Oct;76(4):272-9. doi: 10.1111/aji.12547. Epub 2016 Aug 
      1.