PMID- 27476761
OWN - NLM
STAT- MEDLINE
DCOM- 20171213
LR  - 20180403
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 76
IP  - 3
DP  - 2016 Sep
TI  - Effects of bilateral vasectomy on the interleukin 1 system in mouse epididymis.
PG  - 235-42
LID - 10.1111/aji.12548 [doi]
AB  - PROBLEM: Regional difference in the inflammatory response in vasectomized (VAX) 
      epididymis remains unraveled. METHOD OF STUDY: Epididymal expression of 
      interleukin 1alpha (IL1alpha), IL1beta, IL1 receptor antagonist (IL1ra), IL1 receptor 1 
      (IL1R1), IL6, IL10, tumor necrosis factor alpha (TNF-alpha), and transforming growth 
      factor-beta1 (TGF-beta1) was examined in bilateral VAX mice by real-time RT-PCR and 
      immunohistochemistry. RESULTS: IL1alpha, IL1beta, IL1ra, and IL1R1 were expressed in the 
      epididymal epithelia of normal mice. Following VAX, IL1R1 mRNA was not changed, 
      but TNF-alpha, IL10, IL1alpha, IL1beta, and IL1ra mRNA were significantly upregulated in 
      whole epididymis, whereas IL6 and TGF-beta1 mRNA were significantly increased in 
      corpus and cauda but not in caput epididymis. Consistently, IL1alpha, IL1beta, and IL1ra 
      immunoreactivities were visibly increased in epididymis following VAX. 
      CONCLUSION: Following VAX, IL1alpha, IL1beta, IL1ra, IL10, and TNF-alpha may mediate immune 
      reaction in whole epididymis, whereas IL6 and TGF-beta1 may mediate regionally 
      different immune response primarily in the lower part of epididymis.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Oh, Yeong Seok
AU  - Oh YS
AD  - Department of Life Science and Research Institute for Natural Sciences, Hanyang 
      University, Seoul, Korea.
FAU - Na, Eun Ju
AU  - Na EJ
AD  - Department of Life Science and Research Institute for Natural Sciences, Hanyang 
      University, Seoul, Korea.
FAU - Gye, Myung Chan
AU  - Gye MC
AD  - Department of Life Science and Research Institute for Natural Sciences, Hanyang 
      University, Seoul, Korea.
LA  - eng
SI  - GENBANK/NM_008361
SI  - GENBANK/NM_008362
SI  - GENBANK/NM_010548
SI  - GENBANK/NM_010554
SI  - GENBANK/NM_011291
SI  - GENBANK/NM_011577
SI  - GENBANK/NM_013693
SI  - GENBANK/NM_031167
SI  - GENBANK/NM_031168
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160801
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (IL10 protein, mouse)
RN  - 0 (IL1B protein, mouse)
RN  - 0 (IL1R1 protein, mouse)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1alpha)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Interleukin-1 Type I)
RN  - 0 (Tgfb1 protein, mouse)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (interleukin-6, mouse)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Epididymis/immunology/surgery
MH  - Interleukin 1 Receptor Antagonist Protein/*immunology
MH  - Interleukin-10/*immunology
MH  - Interleukin-1alpha/*immunology
MH  - Interleukin-1beta/*immunology
MH  - Interleukin-6/*immunology
MH  - Male
MH  - Mice
MH  - Receptors, Interleukin-1 Type I/immunology
MH  - Transforming Growth Factor beta1/*immunology
MH  - Tumor Necrosis Factor-alpha/*immunology
MH  - *Vasectomy
OTO - NOTNLM
OT  - epididymis
OT  - interleukin 1
OT  - mouse
OT  - vasectomy
EDAT- 2016/08/02 06:00
MHDA- 2017/12/14 06:00
CRDT- 2016/08/02 06:00
PHST- 2016/03/24 00:00 [received]
PHST- 2016/07/13 00:00 [accepted]
PHST- 2016/08/02 06:00 [entrez]
PHST- 2016/08/02 06:00 [pubmed]
PHST- 2017/12/14 06:00 [medline]
AID - 10.1111/aji.12548 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2016 Sep;76(3):235-42. doi: 10.1111/aji.12548. Epub 2016 Aug 
      1.