PMID- 27478459
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160801
LR  - 20220321
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 12
IP  - 4
DP  - 2016 Aug 1
TI  - Cytokine profiling in exhaled breath condensate after exercise challenge in 
      asthmatic children with post-exercise symptoms.
PG  - 778-84
LID - 10.5114/aoms.2015.48547 [doi]
AB  - INTRODUCTION: Markers of exhaled breath condensate (EBC) correlate with lung 
      function impairment, airway remodeling and different aspects of the disease such 
      as exercise-induced bronchoconstriction (EIB). Aim of the study was to determine 
      the cytokine profile in EBC of children with asthma after an exercise treadmill 
      challenge in order to obtain clinically useful information about mechanisms of 
      EIB; also, to assess correlations between cytokine concentrations in EBC and 
      clinical characteristics of the patients. MATERIAL AND METHODS: The study 
      population consisted of 25 randomly selected children, aged 8 to 19 years, with 
      asthma and EIB symptoms despite the use of control medications. Patients on the 
      day of the study visit underwent fractional exhaled nitric oxide measurement 
      (FeNO) and baseline spirometry, performed an exercise treadmill challenge (ETC), 
      and EBC samples were obtained at the end of the ETC. RESULTS: In asthmatic 
      children with positive ETC, monocyte hemotactic protein-1 (MCP-1) and IL-16 
      adjusted to pre-EBC forced expiratory volume in 1 s (FEV1) were significantly 
      higher compared to children with negative ETC (p = 0.022 and p = 0.017 
      respectively). After adjustment to pre-EBC FEV1 other cytokines (IL-4, IL-5, 
      IL-6, IL-8, MIG, TNF-alpha) were not related to post-exercise changes in FEV1. 
      CONCLUSIONS: We observed a specific inflammatory profile in the airways of 
      asthmatic children with bronchoconstriction induced by exercise. The 
      concentration of cytokines in EBC depended on the post-exercise decrease in FEV1, 
      which was measured by the area under the curve (AUC). MCP-1 and IL-16, adjusted 
      to pre-EBC FEV1, were significantly higher in children with a positive exercise 
      challenge compared to those with a negative one.
FAU - Majak, Pawel
AU  - Majak P
AD  - Department of Internal Medicine, Asthma and Allergy, Barlicki University 
      Hospital, Medical University of Lodz, Lodz, Poland.
FAU - Jerzynska, Joanna
AU  - Jerzynska J
AD  - Department of Paediatrics and Allergy, Medical University of Lodz, Lodz, Poland.
FAU - Bojo, Magdalena
AU  - Bojo M
AD  - Department of Paediatrics and Allergy, Medical University of Lodz, Lodz, Poland.
FAU - Brzozowska, Agnieszka
AU  - Brzozowska A
AD  - Department of Paediatrics and Allergy, Medical University of Lodz, Lodz, Poland.
FAU - Koczkowska, Magdalena
AU  - Koczkowska M
AD  - Department of Biology and Genetics, Medical University of Gdansk, Gdansk, Poland.
FAU - Sielski, Piotr
AU  - Sielski P
AD  - Faculty of Mathematics and Computer Science, University of Lodz, Lodz, Poland.
FAU - Stelmach, Wlodzimierz
AU  - Stelmach W
AD  - Department of Social and Preventive Medicine, Medical University of Lodz, Lodz, 
      Poland.
FAU - Stelmach, Rafal
AU  - Stelmach R
AD  - Institute of Dental Surgery, Faculty of Medicine and Dentistry, Medical 
      University of Lodz, Lodz, Poland.
FAU - Janas, Anna
AU  - Janas A
AD  - Institute of Dental Surgery, Faculty of Medicine and Dentistry, Medical 
      University of Lodz, Lodz, Poland.
FAU - Stelmach, Iwona
AU  - Stelmach I
AD  - Department of Paediatrics and Allergy, Medical University of Lodz, Lodz, Poland.
LA  - eng
PT  - Journal Article
DEP - 20160701
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC4947605
OTO - NOTNLM
OT  - asthma
OT  - children
OT  - cytokines
OT  - exercise-induced bronchoconstriction
OT  - exhaled breath condensate
EDAT- 2016/08/02 06:00
MHDA- 2016/08/02 06:01
PMCR- 2016/08/01
CRDT- 2016/08/02 06:00
PHST- 2014/08/01 00:00 [received]
PHST- 2014/12/21 00:00 [accepted]
PHST- 2016/08/02 06:00 [entrez]
PHST- 2016/08/02 06:00 [pubmed]
PHST- 2016/08/02 06:01 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - 24402 [pii]
AID - 10.5114/aoms.2015.48547 [doi]
PST - ppublish
SO  - Arch Med Sci. 2016 Aug 1;12(4):778-84. doi: 10.5114/aoms.2015.48547. Epub 2016 
      Jul 1.