PMID- 27478850
OWN - NLM
STAT- MEDLINE
DCOM- 20170606
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - Analysis of Inflammatory Mediators in Prediabetes and Newly Diagnosed Type 2 
      Diabetes Patients.
PG  - 7965317
LID - 10.1155/2016/7965317 [doi]
LID - 7965317
AB  - This study evaluated the inflammatory markers in prediabetes and newly diagnosed 
      type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using 
      one-way analysis of covariance and the association with prediabetes or T2DM risks 
      was examined by logistic regression models. Our data showed increased levels of 
      hypersensitivity C-reactive protein (hs-CRP), interleukin (IL-4), IL-10, and 
      tryptase in prediabetes subjects and hs-CRP, immunoglobulin E (IgE), IL-4, and 
      IL-10 in T2DM subjects. We concluded that Hs-CRP, IgE, IL-4, IL-10, and tryptase 
      were positively associated with prediabetes or T2DM. Further large prospective 
      studies are warranted to assess a temporal relation between inflammatory 
      biomarkers and incidence of prediabetes or T2DM and its associated chronic 
      diseases.
FAU - Wang, Zhen
AU  - Wang Z
AUID- ORCID: 0000-0003-4553-907X
AD  - Department of Clinical Medicine, School of Nursing & Medicine, Huzhou University, 
      Huzhou, Zhejiang 313000, China.
FAU - Shen, Xu-Hui
AU  - Shen XH
AUID- ORCID: 0000-0003-3092-6667
AD  - Department of Nursing Medicine, School of Nursing & Medicine, Huzhou University, 
      Huzhou, Zhejiang 313000, China.
FAU - Feng, Wen-Ming
AU  - Feng WM
AD  - Surgery Department, Huzhou Wu Xing People's Hospital, Huzhou, Zhejiang 313008, 
      China.
FAU - Ye, Guo-Fen
AU  - Ye GF
AUID- ORCID: 0000-0001-6015-0578
AD  - Physical Examination Center, Zhebei Clinical Medicine Hospital, Huzhou 
      University, Huzhou, Zhejiang 313000, China.
FAU - Qiu, Wei
AU  - Qiu W
AD  - Endocrinology Department, Zhebei Clinical Medicine Hospital, Huzhou University, 
      Huzhou, Zhejiang 313000, China.
FAU - Li, Bo
AU  - Li B
AUID- ORCID: 0000-0003-3547-5594
AD  - Huanzhu Street Community Health Center, Huzhou, Zhejiang 313000, China.
LA  - eng
PT  - Journal Article
DEP - 20160705
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (IL10 protein, human)
RN  - 0 (IL4 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Aged
MH  - C-Reactive Protein/immunology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*immunology/metabolism
MH  - Female
MH  - Forkhead Transcription Factors/metabolism
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Inflammation Mediators/*immunology/metabolism
MH  - Interleukin-10/immunology
MH  - Interleukin-4/immunology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*immunology/metabolism
MH  - Tryptases/immunology
MH  - Tumor Necrosis Factor-alpha/immunology
PMC - PMC4949350
EDAT- 2016/08/02 06:00
MHDA- 2017/06/07 06:00
PMCR- 2016/07/05
CRDT- 2016/08/02 06:00
PHST- 2016/04/12 00:00 [received]
PHST- 2016/06/05 00:00 [accepted]
PHST- 2016/08/02 06:00 [entrez]
PHST- 2016/08/02 06:00 [pubmed]
PHST- 2017/06/07 06:00 [medline]
PHST- 2016/07/05 00:00 [pmc-release]
AID - 10.1155/2016/7965317 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:7965317. doi: 10.1155/2016/7965317. Epub 2016 Jul 5.