PMID- 27481733
OWN - NLM
STAT- MEDLINE
DCOM- 20170913
LR  - 20181202
IS  - 1557-8615 (Electronic)
IS  - 0883-9441 (Linking)
VI  - 35
DP  - 2016 Oct
TI  - Opioid overdose leading to intensive care unit admission: Epidemiology and 
      outcomes.
PG  - 29-32
LID - S0883-9441(16)30048-X [pii]
LID - 10.1016/j.jcrc.2016.04.022 [doi]
AB  - PURPOSE: There is a scarcity of studies assessing the patient population admitted 
      to the intensive care unit (ICU) with opioid overdose. We sought to characterize 
      the epidemiologic features and outcomes of this patient population. MATERIALS AND 
      METHODS: This is a retrospective cohort study of adult patients admitted to the 
      ICU at University of Louisville Hospital for opioid overdose. We reviewed each 
      patient's hospital record for demographic data, comorbidities, opioid used, 
      coingestions, and outcomes. RESULTS: We included 178 adult patients, of which 107 
      (60%) were females. The median age was 41 years (interquartile range [IQR], 23). 
      Oxycodone and hydrocodone were the 2 most commonly abused opioids. 
      Benzodiazepines were the most common drug coingested, followed by amphetamines. 
      Tobacco smoking, chronic pain, and alcoholism were the most frequent 
      comorbidities identified. Mental disorders were also common. Most patients 
      required invasive mechanical ventilation (84.8%). Median ICU length of stay was 3 
      days. Eighteen patients (10.1%) died in the hospital, whereas 6 patients (3.4%) 
      were discharged to a nursing home. Patients who had any coingestion were 
      significantly more likely to undergo invasive mechanical ventilation (91% vs 77%; 
      P=.014) and had longer ICU length of stay (3 [IQR, 2] vs 2 [IQR, 1.8] days; 
      P=.024). CONCLUSION: Opioid overdose is a common cause of ICU admission and 
      affects a relatively young population. Most have respiratory failure requiring 
      mechanical ventilation. It is associated with a relatively high inhospital 
      mortality. Coingestions appear to have an impact on outcomes.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Pfister, Gregory J
AU  - Pfister GJ
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of 
      Louisville, Louisville, KY.
FAU - Burkes, Robert M
AU  - Burkes RM
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of 
      Louisville, Louisville, KY.
FAU - Guinn, Brian
AU  - Guinn B
AD  - Division of Infectious Diseases, University of Louisville, Louisville, KY.
FAU - Steele, Jacquelene
AU  - Steele J
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of 
      Louisville, Louisville, KY.
FAU - Kelley, Robert R
AU  - Kelley RR
AD  - Division of Infectious Diseases, University of Louisville, Louisville, KY.
FAU - Wiemken, Timothy L
AU  - Wiemken TL
AD  - Division of Infectious Diseases, University of Louisville, Louisville, KY.
FAU - Saad, Mohamed
AU  - Saad M
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of 
      Louisville, Louisville, KY.
FAU - Ramirez, Julio
AU  - Ramirez J
AD  - Division of Infectious Diseases, University of Louisville, Louisville, KY.
FAU - Cavallazzi, Rodrigo
AU  - Cavallazzi R
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of 
      Louisville, Louisville, KY.
LA  - eng
PT  - Journal Article
DEP - 20160430
PL  - United States
TA  - J Crit Care
JT  - Journal of critical care
JID - 8610642
RN  - 0 (Analgesics, Opioid)
SB  - IM
CIN - J Crit Care. 2017 Feb;37:259-260. PMID: 27667682
MH  - Adult
MH  - Analgesics, Opioid/*poisoning
MH  - Cohort Studies
MH  - Critical Care
MH  - Drug Overdose/*epidemiology/mortality/therapy
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Intensive Care Units
MH  - Kentucky/epidemiology
MH  - Length of Stay
MH  - Male
MH  - Opioid-Related Disorders/*epidemiology/mortality/therapy
MH  - *Patient Admission
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Drug abuse
OT  - Intensive care unit
OT  - Mechanical ventilation
OT  - Mortality
OT  - Opioid
OT  - Overdose
EDAT- 2016/08/03 06:00
MHDA- 2017/09/14 06:00
CRDT- 2016/08/03 06:00
PHST- 2016/01/24 00:00 [received]
PHST- 2016/04/08 00:00 [revised]
PHST- 2016/04/26 00:00 [accepted]
PHST- 2016/08/03 06:00 [entrez]
PHST- 2016/08/03 06:00 [pubmed]
PHST- 2017/09/14 06:00 [medline]
AID - S0883-9441(16)30048-X [pii]
AID - 10.1016/j.jcrc.2016.04.022 [doi]
PST - ppublish
SO  - J Crit Care. 2016 Oct;35:29-32. doi: 10.1016/j.jcrc.2016.04.022. Epub 2016 Apr 
      30.