PMID- 27482434
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160802
LR  - 20201001
IS  - 2055-6640 (Print)
IS  - 2055-6659 (Electronic)
IS  - 2055-6640 (Linking)
VI  - 2
IP  - 1
DP  - 2016 Jan 1
TI  - Factors associated with HIV RNA viral loads in ART-naive patients: implications 
      for treatment as prevention in concentrated epidemics.
PG  - 36-42
AB  - BACKGROUND: Limited data are available on factors associated with HIV-RNA viral 
      load (VL) among antiretroviral treatment (ART)-naive key populations in 
      concentrated epidemics. METHODS: We conducted a cross-sectional survey of 1211 
      adult ART-naive patients at 19 HIV clinics in Ho Chi Minh City (HCMC), Vietnam. 
      Data collection included a standardised questionnaire, routine laboratory 
      testing, hepatitis serology and HIV VL. Correlation between CD4 cell count and VL 
      was assessed across all participants. In 904 participants not meeting Vietnam 
      criteria for ART (CD4 cell count >350 cells/mm(3), WHO clinical stage 1 or 2 and 
      not pregnant), multivariate analyses were conducted to assess factors associated 
      with HIV VL. RESULTS: Pre-ART patients had a median age of 31 years and 54% were 
      male. Median CD4 cell count was 533 cells/mm(3). Median HIV VL was 17,378 
      copies/mL; 60% had VL greater than 10,000 copies/mL and 16% had VL above 
      100,000 copies/mL. Although declining CD4 cell count was correlated with rising 
      VL across all CD4 cell counts, correlation of VL with CD4 cell counts between 351 
      and 500 cell/mm(3) was not significant. On multivariate linear regression, higher 
      HIV VL was independently associated with male sex, men who have sex with men 
      (MSM), CD4 cell count 351-500, HIV diagnosis within the previous 6 months, and 
      hepatitis B (HBV). Lower HIV VL was independently associated with hepatitis C 
      (HCV). CONCLUSIONS: The majority of HIV patients who were not eligible for ART in 
      HCMC in 2014 had HIV VL greater than 10,000 copies/mL. These data support 
      expanded eligibility of ART to all HIV patients with the goal of treatment as 
      prevention. This study is also among the first to demonstrate that MSM had a 
      higher VL than women and heterosexual men and highlights the need for improved 
      outreach and linkages to HIV care for this high-risk group.
FAU - Rangarajan, Suresh
AU  - Rangarajan S
AD  - FHI 360 , Ho Chi Minh City , Vietnam.
FAU - Colby, Donn J
AU  - Colby DJ
AD  - Center for Applied Research on Men and Health, Ho Chi Minh City, Vietnam; SEARCH, 
      Thai Red Cross AIDS Research Center, Bangkok, Thailand.
FAU - Truong, Giang Le
AU  - Truong GL
AD  - Ho Chi Minh City Provincial AIDS Committee , Ho Chi Minh City , Vietnam.
FAU - Huu, Hung Nguyen
AU  - Huu HN
AD  - Ho Chi Minh City Provincial AIDS Committee , Ho Chi Minh City , Vietnam.
FAU - Thu, Van Tieu Thi
AU  - Thu VT
AD  - Ho Chi Minh City Provincial AIDS Committee , Ho Chi Minh City , Vietnam.
FAU - Quoc, Binh Luong
AU  - Quoc BL
AD  - Ho Chi Minh City Provincial AIDS Committee , Ho Chi Minh City , Vietnam.
FAU - Broh, Tou Plui
AU  - Broh TP
AD  - FHI 360 , Ho Chi Minh City , Vietnam.
FAU - Tri, Danh Tran
AU  - Tri DT
AD  - FHI 360 , Ho Chi Minh City , Vietnam.
FAU - Giang, Dao Duc
AU  - Giang DD
AD  - FHI 360 , Hanoi , Vietnam.
FAU - Chen, Mario
AU  - Chen M
AD  - FHI 360 North Carolina , USA.
FAU - Zeng, Yanwu
AU  - Zeng Y
AD  - FHI 360 North Carolina , USA.
FAU - West, Gary
AU  - West G
AD  - FHI 360 (retired).
LA  - eng
PT  - Journal Article
DEP - 20160101
PL  - England
TA  - J Virus Erad
JT  - Journal of virus eradication
JID - 101654142
PMC - PMC4946694
OTO - NOTNLM
OT  - ART naive
OT  - HIV
OT  - HIV viral load
OT  - Vietnam
OT  - treatment as prevention
EDAT- 2016/08/03 06:00
MHDA- 2016/08/03 06:01
PMCR- 2016/01/01
CRDT- 2016/08/03 06:00
PHST- 2016/08/03 06:00 [entrez]
PHST- 2016/08/03 06:00 [pubmed]
PHST- 2016/08/03 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
PST - epublish
SO  - J Virus Erad. 2016 Jan 1;2(1):36-42.