PMID- 27483336
OWN - NLM
STAT- MEDLINE
DCOM- 20180403
LR  - 20240327
IS  - 1536-5948 (Electronic)
IS  - 1076-2752 (Print)
IS  - 1076-2752 (Linking)
VI  - 58
IP  - 10
DP  - 2016 Oct
TI  - Air Pollution During Pregnancy and Cord Blood Immune System Biomarkers.
PG  - 979-986
AB  - OBJECTIVES: We aimed to determine whether average and trimester-specific 
      exposures to ambient measures of nitrogen dioxide (NO2) and particular matter 
      (PM2.5) were associated with elevated cord blood concentrations of immunoglobulin 
      E (IgE) and two epithelial cell produced cytokines: interleukin-33 (IL-33) and 
      thymic stromal lymphopoietin (TSLP). METHODS: This study utilized data and 
      biospecimens from the Maternal-Infant Research on Environmental Chemicals (MIREC) 
      Study. There were 2001 pregnant women recruited between 2008 and 2011 from 10 
      Canadian cities. Maternal exposure to NO2 and PM2.5 was estimated using land use 
      regression and satellite-derived models. RESULTS: We observed statistically 
      significant associations between maternal NO2 exposure and elevated cord blood 
      concentrations of both IL-33 and TSLP among girls but not boys. CONCLUSIONS: 
      Maternal NO2 exposure may impact the development of the newborn immune system as 
      measured by cord blood concentrations of two cytokines.
FAU - Ashley-Martin, Jillian
AU  - Ashley-Martin J
AD  - Departments of Obstetrics & Gynecology and Pediatrics, Dalhousie University, 
      Halifax, Nova Scotia (Drs Ashley-Martin, Dodds); Air Health Science Division (Drs 
      Lavigne, Johnson), Population Studies Division, Healthy Environments and Consumer 
      Safety Branch, Health Canada, Ottawa, Ontario, Canada (Dr Arbuckle); College of 
      Public Health and Human Sciences, Oregon State University, Corvallis (Dr Hystad); 
      Department of Sociology, University of New Brunswick, Fredericton, New Brunswick 
      (Dr Crouse); and Department of Microbiology and Immunology, Dalhousie University, 
      Halifax, Nova Scotia, Canada (Dr Marshall).
FAU - Lavigne, Eric
AU  - Lavigne E
FAU - Arbuckle, Tye E
AU  - Arbuckle TE
FAU - Johnson, Markey
AU  - Johnson M
FAU - Hystad, Perry
AU  - Hystad P
FAU - Crouse, Dan L
AU  - Crouse DL
FAU - Marshall, Jean S
AU  - Marshall JS
FAU - Dodds, Linda
AU  - Dodds L
LA  - eng
GR  - MOP - 81285/Canadian Institutes for Health Research/International
PT  - Journal Article
PL  - United States
TA  - J Occup Environ Med
JT  - Journal of occupational and environmental medicine
JID - 9504688
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (IL33 protein, human)
RN  - 0 (Interleukin-33)
RN  - 0 (Particulate Matter)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - S7G510RUBH (Nitrogen Dioxide)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Air Pollution/*analysis
MH  - Biomarkers/blood
MH  - Canada
MH  - Cities
MH  - Cytokines/blood
MH  - Female
MH  - Fetal Blood/*immunology
MH  - Humans
MH  - Immune System
MH  - Immunoglobulin E/blood
MH  - Infant, Newborn
MH  - Interleukin-33/blood
MH  - Male
MH  - *Maternal Exposure
MH  - Nitric Oxide/analysis
MH  - Nitrogen Dioxide
MH  - Particulate Matter/analysis
MH  - Pregnancy
MH  - Thymic Stromal Lymphopoietin
PMC - PMC5704662
COIS- Authors Dodds, Ashley-Martin, Lavigne, Arbuckle, Johnson, Hystad, Crouse, and 
      Marshall have no other relationships/conditions/circumstances that present 
      potential conflict of interest. The authors report no conflicts of interest.
EDAT- 2016/10/19 06:00
MHDA- 2018/04/04 06:00
PMCR- 2017/11/28
CRDT- 2016/08/03 06:00
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2018/04/04 06:00 [medline]
PHST- 2016/08/03 06:00 [entrez]
PHST- 2017/11/28 00:00 [pmc-release]
AID - 10.1097/JOM.0000000000000841 [doi]
PST - ppublish
SO  - J Occup Environ Med. 2016 Oct;58(10):979-986. doi: 10.1097/JOM.0000000000000841.