PMID- 27485011
OWN - NLM
STAT- MEDLINE
DCOM- 20161229
LR  - 20181202
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 15
IP  - 11
DP  - 2016 Nov
TI  - Tolerogenic dendritic cells for reprogramming of lymphocyte responses in 
      autoimmune diseases.
PG  - 1071-1080
LID - S1568-9972(16)30177-X [pii]
LID - 10.1016/j.autrev.2016.07.032 [doi]
AB  - Dendritic cells (DCs) control immune responses by driving potent inflammatory 
      actions against external and internal threats while generating tolerance to self 
      and harmless components. This duality and their potential to reprogram immune 
      responses in an antigen-specific fashion have made them an interesting target for 
      immunotherapeutic strategies to control autoimmune diseases. Several protocols 
      have been described for in vitro generation of tolerogenic DCs (tolDCs) capable 
      of modulating adaptive immune responses and restoring tolerance through different 
      mechanisms that involve anergy, generation of regulatory lymphocyte populations, 
      or deletion of potentially harmful inflammatory T cell subsets. Recently, the 
      capacity of tolDCs to induce interleukin (IL-10)-secreting regulatory B cells has 
      been demonstrated. In vitro assays and rodent models of autoimmune diseases 
      provide insights to the molecular regulators and pathways enabling tolDCs to 
      control immune responses. Here we review mechanisms through which tolDCs modulate 
      adaptive immune responses, particularly focusing on their suitability for 
      reprogramming autoreactive CD4(+) effector T cells. Furthermore, we discuss 
      recent findings establishing that tolDCs also modulate B cell populations and 
      discuss clinical trials applying tolDCs to patients with autoimmune diseases.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Garcia-Gonzalez, Paulina
AU  - Garcia-Gonzalez P
AD  - Immune Regulation and Tolerance Research Group, Programa Disciplinario de 
      Inmunologia, Instituto de Ciencias Biomedicas (ICBM), Facultad de Medicina, 
      Universidad de Chile, Santiago, Chile; Millenium Institute on Immunology and 
      Immunotherapy (IMII), Santiago, Chile.
FAU - Ubilla-Olguin, Gabriela
AU  - Ubilla-Olguin G
AD  - Immune Regulation and Tolerance Research Group, Programa Disciplinario de 
      Inmunologia, Instituto de Ciencias Biomedicas (ICBM), Facultad de Medicina, 
      Universidad de Chile, Santiago, Chile; Millenium Institute on Immunology and 
      Immunotherapy (IMII), Santiago, Chile.
FAU - Catalan, Diego
AU  - Catalan D
AD  - Immune Regulation and Tolerance Research Group, Programa Disciplinario de 
      Inmunologia, Instituto de Ciencias Biomedicas (ICBM), Facultad de Medicina, 
      Universidad de Chile, Santiago, Chile; Millenium Institute on Immunology and 
      Immunotherapy (IMII), Santiago, Chile.
FAU - Schinnerling, Katina
AU  - Schinnerling K
AD  - Immune Regulation and Tolerance Research Group, Programa Disciplinario de 
      Inmunologia, Instituto de Ciencias Biomedicas (ICBM), Facultad de Medicina, 
      Universidad de Chile, Santiago, Chile; Millenium Institute on Immunology and 
      Immunotherapy (IMII), Santiago, Chile. Electronic address: 
      katina.schinnerling@gmail.com.
FAU - Aguillon, Juan Carlos
AU  - Aguillon JC
AD  - Immune Regulation and Tolerance Research Group, Programa Disciplinario de 
      Inmunologia, Instituto de Ciencias Biomedicas (ICBM), Facultad de Medicina, 
      Universidad de Chile, Santiago, Chile; Millenium Institute on Immunology and 
      Immunotherapy (IMII), Santiago, Chile. Electronic address: 
      jaguillo@med.uchile.cl.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160730
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/*immunology/therapy
MH  - B-Lymphocytes/immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Immune Tolerance
MH  - Mice
EDAT- 2016/10/25 06:00
MHDA- 2016/12/31 06:00
CRDT- 2016/08/04 06:00
PHST- 2016/07/13 00:00 [received]
PHST- 2016/07/16 00:00 [accepted]
PHST- 2016/10/25 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
PHST- 2016/08/04 06:00 [entrez]
AID - S1568-9972(16)30177-X [pii]
AID - 10.1016/j.autrev.2016.07.032 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2016 Nov;15(11):1071-1080. doi: 10.1016/j.autrev.2016.07.032. Epub 
      2016 Jul 30.