PMID- 27485293
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20181113
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Print)
IS  - 0895-4356 (Linking)
VI  - 80
DP  - 2016 Dec
TI  - The Moses-Littenberg meta-analytical method generates systematic differences in 
      test accuracy compared to hierarchical meta-analytical models.
PG  - 77-87
LID - S0895-4356(16)30258-X [pii]
LID - 10.1016/j.jclinepi.2016.07.011 [doi]
AB  - OBJECTIVE: To compare meta-analyses of diagnostic test accuracy using the 
      Moses-Littenberg summary receiver operating characteristic (SROC) approach with 
      those of the hierarchical SROC (HSROC) model. STUDY DESIGN AND SETTING: 
      Twenty-six data sets from existing test accuracy systematic reviews were 
      reanalyzed with the Moses-Littenberg model, using equal weighting ("E-ML") and 
      weighting by the inverse variance of the log DOR ("W-ML"), and with the HSROC 
      model. The diagnostic odds ratios (DORs) were estimated and covariates added to 
      both models to estimate relative DORs (RDORs) between subgroups. Models were 
      compared by calculating the ratio of DORs, the ratio of RDORs, and P-values for 
      detecting asymmetry and effects of covariates on DOR. RESULTS: Compared to the 
      HSROC model, the Moses-Littenberg model DOR estimates were a median of 22% 
      ("E-ML") and 47% ("W-ML") lower at Q*, and 7% and 42% lower at the central point 
      in the data. Instances of the ML models giving estimates higher than the HSROC 
      model also occurred. Investigations of heterogeneity also differed; the 
      Moses-Littenberg models on average estimating smaller differences in RDOR. 
      CONCLUSIONS: Moses-Littenberg meta-analyses can generate lower estimates of test 
      accuracy, and smaller differences in accuracy, compared to mathematically 
      superior hierarchical models. This has implications for the usefulness of 
      meta-analyses using this approach. We recommend meta-analysis of diagnostic test 
      accuracy studies to be conducted using available hierarchical model-based 
      approaches.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Dinnes, Jacqueline
AU  - Dinnes J
AD  - Biostatistics, Evidence Synthesis and Test Evaluation Research Group, Institute 
      for Applied Health Research, University of Birmingham, Edgbaston, Birmingham B15 
      2TT, UK.
FAU - Mallett, Susan
AU  - Mallett S
AD  - Biostatistics, Evidence Synthesis and Test Evaluation Research Group, Institute 
      for Applied Health Research, University of Birmingham, Edgbaston, Birmingham B15 
      2TT, UK.
FAU - Hopewell, Sally
AU  - Hopewell S
AD  - Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, 
      Rheumatology and Musculoskeletal Sciences, University of Oxford/Botnar Research 
      Centre, Windmill Road, Oxford OX3 7LD, UK.
FAU - Roderick, Paul J
AU  - Roderick PJ
AD  - Department of Public Health Sciences and Medical Statistics, University of 
      Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, 
      UK.
FAU - Deeks, Jonathan J
AU  - Deeks JJ
AD  - Biostatistics, Evidence Synthesis and Test Evaluation Research Group, Institute 
      for Applied Health Research, University of Birmingham, Edgbaston, Birmingham B15 
      2TT, UK. Electronic address: j.deeks@bham.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160730
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - Diagnostic Tests, Routine/*standards/statistics & numerical data
MH  - Humans
MH  - *Meta-Analysis as Topic
MH  - Odds Ratio
MH  - ROC Curve
MH  - *Reproducibility of Results
PMC - PMC5176007
OTO - NOTNLM
OT  - Diagnostic odds ratio
OT  - Diagnostic test accuracy
OT  - Hierarchical models
OT  - Meta-analysis
OT  - Summary ROC curves
OT  - Systematic review
EDAT- 2016/10/30 06:00
MHDA- 2017/06/27 06:00
PMCR- 2016/12/01
CRDT- 2016/08/04 06:00
PHST- 2016/02/26 00:00 [received]
PHST- 2016/06/18 00:00 [revised]
PHST- 2016/07/23 00:00 [accepted]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2016/08/04 06:00 [entrez]
PHST- 2016/12/01 00:00 [pmc-release]
AID - S0895-4356(16)30258-X [pii]
AID - 10.1016/j.jclinepi.2016.07.011 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2016 Dec;80:77-87. doi: 10.1016/j.jclinepi.2016.07.011. Epub 
      2016 Jul 30.