PMID- 27486271
OWN - NLM
STAT- MEDLINE
DCOM- 20171031
LR  - 20231213
IS  - 1741-7899 (Electronic)
IS  - 1470-1626 (Linking)
VI  - 152
IP  - 5
DP  - 2016 Nov
TI  - Effects of neonatal exposure to a glyphosate-based herbicide on female rat 
      reproduction.
PG  - 403-15
LID - 10.1530/REP-16-0171 [doi]
AB  - In this study, we investigated whether neonatal exposure to a glyphosate-based 
      herbicide (GBH) alters the reproductive performance and the molecular mechanisms 
      involved in the decidualization process in adult rats. Newborn female rats 
      received vehicle or 2 mg/kg/day of a GBH on postnatal days (PND) 1, 3, 5 and 7. 
      On PND90, the rats were mated to evaluate (i) the reproductive performance on 
      gestational day (GD) 19 and (ii) the ovarian steroid levels, uterine morphology, 
      endometrial cell proliferation, apoptosis and cell cycle regulators, and 
      endocrine pathways that regulate uterine decidualization (steroid 
      receptors/COUP-TFII/Bmp2/Hoxa10) at the implantation sites (IS) on GD9. The 
      GBH-exposed group showed a significant increase in the number of resorption sites 
      on GD19, associated with an altered decidualization response. In fact, on GD9, 
      the GBH-treated rats showed morphological changes at the IS, associated with a 
      decreased expression of estrogen and progesterone receptors, a downregulation of 
      COUP-TFII (Nr2f2) and Bmp2 mRNA and an increased expression of HOXA10 and the 
      proliferation marker Ki67(Mki67) at the IS. We concluded that alterations in 
      endometrial decidualization might be the mechanism of GBH-induced 
      post-implantation embryo loss.
CI  - (c) 2016 Society for Reproduction and Fertility.
FAU - Ingaramo, Paola I
AU  - Ingaramo PI
AD  - Instituto de Salud y Ambiente del Litoral (ISAL)Facultad de Bioquimica y Ciencias 
      Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Varayoud, Jorgelina
AU  - Varayoud J
AD  - Instituto de Salud y Ambiente del Litoral (ISAL)Facultad de Bioquimica y Ciencias 
      Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Milesi, Maria M
AU  - Milesi MM
AD  - Instituto de Salud y Ambiente del Litoral (ISAL)Facultad de Bioquimica y Ciencias 
      Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Schimpf, Marlise Guerrero
AU  - Schimpf MG
AD  - Instituto de Salud y Ambiente del Litoral (ISAL)Facultad de Bioquimica y Ciencias 
      Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Munoz-de-Toro, Monica
AU  - Munoz-de-Toro M
AD  - Instituto de Salud y Ambiente del Litoral (ISAL)Facultad de Bioquimica y Ciencias 
      Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina.
FAU - Luque, Enrique H
AU  - Luque EH
AD  - Instituto de Salud y Ambiente del Litoral (ISAL)Facultad de Bioquimica y Ciencias 
      Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas (CONICET), Santa Fe, Argentina 
      eluque@fbcb.unl.edu.ar.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160802
PL  - England
TA  - Reproduction
JT  - Reproduction (Cambridge, England)
JID - 100966036
RN  - 0 (Herbicides)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - Decidua/drug effects/growth & development
MH  - Endometrium/drug effects/growth & development
MH  - Female
MH  - Glycine/*analogs & derivatives/toxicity
MH  - Herbicides/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*physiopathology
MH  - Rats
MH  - Reproduction/drug effects/*physiology
MH  - Uterus/drug effects/growth & development
MH  - Glyphosate
EDAT- 2016/08/04 06:00
MHDA- 2017/11/01 06:00
CRDT- 2016/08/04 06:00
PHST- 2016/03/29 00:00 [received]
PHST- 2016/08/01 00:00 [accepted]
PHST- 2016/08/04 06:00 [entrez]
PHST- 2016/08/04 06:00 [pubmed]
PHST- 2017/11/01 06:00 [medline]
AID - REP-16-0171 [pii]
AID - 10.1530/REP-16-0171 [doi]
PST - ppublish
SO  - Reproduction. 2016 Nov;152(5):403-15. doi: 10.1530/REP-16-0171. Epub 2016 Aug 2.