PMID- 27487877
OWN - NLM
STAT- MEDLINE
DCOM- 20170308
LR  - 20191210
IS  - 2473-4209 (Electronic)
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Linking)
VI  - 43
IP  - 8
DP  - 2016 Aug
TI  - Multisource inverse-geometry CT. Part I. System concept and development.
PG  - 4607
LID - 10.1118/1.4954846 [doi]
AB  - PURPOSE: This paper presents an overview of multisource inverse-geometry computed 
      tomography (IGCT) as well as the development of a gantry-based research prototype 
      system. The development of the distributed x-ray source is covered in a companion 
      paper [V. B. Neculaes et al., "Multisource inverse-geometry CT. Part II. X-ray 
      source design and prototype," Med. Phys. 43, 4617-4627 (2016)]. While progress 
      updates of this development have been presented at conferences and in journal 
      papers, this paper is the first comprehensive overview of the multisource 
      inverse-geometry CT concept and prototype. The authors also provide a review of 
      all previous IGCT related publications. METHODS: The authors designed and 
      implemented a gantry-based 32-source IGCT scanner with 22 cm field-of-view, 16 cm 
      z-coverage, 1 s rotation time, 1.09 x 1.024 mm detector cell size, as low as 0.4 
      x 0.8 mm focal spot size and 80-140 kVp x-ray source voltage. The system is built 
      using commercially available CT components and a custom made distributed x-ray 
      source. The authors developed dedicated controls, calibrations, and 
      reconstruction algorithms and evaluated the system performance using phantoms and 
      small animals. RESULTS: The authors performed IGCT system experiments and 
      demonstrated tube current up to 125 mA with up to 32 focal spots. The authors 
      measured a spatial resolution of 13 lp/cm at 5% cutoff. The scatter-to-primary 
      ratio is estimated 62% for a 32 cm water phantom at 140 kVp. The authors scanned 
      several phantoms and small animals. The initial images have relatively high noise 
      due to the low x-ray flux levels but minimal artifacts. CONCLUSIONS: IGCT has 
      unique benefits in terms of dose-efficiency and cone-beam artifacts, but comes 
      with challenges in terms of scattered radiation and x-ray flux limits. To the 
      authors' knowledge, their prototype is the first gantry-based IGCT scanner. The 
      authors summarized the design and implementation of the scanner and the authors 
      presented results with phantoms and small animals.
FAU - De Man, Bruno
AU  - De Man B
AD  - CT Systems and Applications Laboratory, GE Global Research, Niskayuna, New York 
      12309.
FAU - Uribe, Jorge
AU  - Uribe J
AD  - Functional Imaging Laboratory, GE Global Research, Niskayuna, New York 12309.
FAU - Baek, Jongduk
AU  - Baek J
AD  - School of Integrated Technology, Yonsei University, Incheon 406-840, South Korea.
FAU - Harrison, Dan
AU  - Harrison D
AD  - CT Systems and Applications Laboratory, GE Global Research, Niskayuna, New York 
      12309.
FAU - Yin, Zhye
AU  - Yin Z
AD  - CT Systems and Applications Laboratory, GE Global Research, Niskayuna, New York 
      12309.
FAU - Longtin, Randy
AU  - Longtin R
AD  - Mechanical Systems Technologies, GE Global Research, Niskayuna, New York 12309.
FAU - Roy, Jaydeep
AU  - Roy J
AD  - Mechanical Systems Technologies, GE Global Research, Niskayuna, New York 12309.
FAU - Waters, Bill
AU  - Waters B
AD  - Design and Development Shops, GE Global Research, Niskayuna, New York 12309.
FAU - Wilson, Colin
AU  - Wilson C
AD  - High Energy Physics Laboratory, GE Global Research, Niskayuna, New York 12309.
FAU - Short, Jonathan
AU  - Short J
AD  - Detector Laboratory, GE Global Research, Niskayuna, New York 12309.
FAU - Inzinna, Lou
AU  - Inzinna L
AD  - High Energy Physics Laboratory, GE Global Research, Niskayuna, New York 12309.
FAU - Reynolds, Joseph
AU  - Reynolds J
AD  - High Frequency Power Electronics Laboratory, GE Global Research, Niskayuna, New 
      York 12309.
FAU - Neculaes, V Bogdan
AU  - Neculaes VB
AD  - High Energy Physics Laboratory, GE Global Research, Niskayuna, New York 12309.
FAU - Frutschy, Kristopher
AU  - Frutschy K
AD  - Mechanical Systems Technologies, GE Global Research, Niskayuna, New York 12309.
FAU - Senzig, Bob
AU  - Senzig B
AD  - Molecular Imaging and Computed Tomography, GE Healthcare, Waukesha, Wisconsin 
      53188.
FAU - Pelc, Norbert
AU  - Pelc N
AD  - Department of Radiology, Stanford University, Stanford, California 94305.
LA  - eng
GR  - R01 EB006837/EB/NIBIB NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
RN  - 059QF0KO0R (Water)
RN  - 9011-14-7 (Polymethyl Methacrylate)
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - Artifacts
MH  - Calibration
MH  - Equipment Design
MH  - Phantoms, Imaging
MH  - Polymethyl Methacrylate
MH  - Rabbits
MH  - Radiation Dosage
MH  - Rats
MH  - Scattering, Radiation
MH  - Tomography Scanners, X-Ray Computed
MH  - Tomography, X-Ray Computed/*instrumentation/*methods
MH  - Water
MH  - X-Rays
PMC - PMC4958105
EDAT- 2016/08/05 06:00
MHDA- 2017/03/09 06:00
PMCR- 2017/08/01
CRDT- 2016/08/05 06:00
PHST- 2016/08/05 06:00 [entrez]
PHST- 2016/08/05 06:00 [pubmed]
PHST- 2017/03/09 06:00 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - 006608MPH [pii]
AID - 1.4954846 [pii]
AID - 10.1118/1.4954846 [doi]
PST - ppublish
SO  - Med Phys. 2016 Aug;43(8):4607. doi: 10.1118/1.4954846.