PMID- 27488504
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Aug 4
TI  - Resting state brain dynamics and its transients: a combined TMS-EEG study.
PG  - 31220
LID - 10.1038/srep31220 [doi]
LID - 31220
AB  - The brain at rest exhibits a spatio-temporally rich dynamics which adheres to 
      systematic behaviours that persist in task paradigms but appear altered in 
      disease. Despite this hypothesis, many rest state paradigms do not act directly 
      upon the rest state and therefore cannot confirm hypotheses about its mechanisms. 
      To address this challenge, we combined transcranial magnetic stimulation (TMS) 
      and electroencephalography (EEG) to study brain's relaxation toward rest 
      following a transient perturbation. Specifically, TMS targeted either the medial 
      prefrontal cortex (MPFC), i.e. part of the Default Mode Network (DMN) or the 
      superior parietal lobule (SPL), involved in the Dorsal Attention Network. TMS was 
      triggered by a given brain state, namely an increase in occipital alpha rhythm 
      power. Following the initial TMS-Evoked Potential, TMS at MPFC enhances the 
      induced occipital alpha rhythm, called Event Related Synchronisation, with a 
      longer transient lifetime than TMS at SPL, and a higher amplitude. Our findings 
      show a strong coupling between MPFC and the occipital alpha power. Although the 
      rest state is organized around a core of resting state networks, the DMN 
      functionally takes a special role among these resting state networks.
FAU - Bonnard, Mireille
AU  - Bonnard M
AD  - Aix Marseille Universite, INS, Institut de Neurosciences des systemes, Marseille, 
      France. Inserm,UMR_S 1106, 13005, Marseille, France.
FAU - Chen, Sophie
AU  - Chen S
AD  - Aix Marseille Universite, INS, Institut de Neurosciences des systemes, Marseille, 
      France. Inserm,UMR_S 1106, 13005, Marseille, France.
FAU - Gaychet, Jerome
AU  - Gaychet J
AD  - Aix Marseille Universite, INS, Institut de Neurosciences des systemes, Marseille, 
      France. Inserm,UMR_S 1106, 13005, Marseille, France.
FAU - Carrere, Marcel
AU  - Carrere M
AD  - Aix Marseille Universite, INS, Institut de Neurosciences des systemes, Marseille, 
      France. Inserm,UMR_S 1106, 13005, Marseille, France.
FAU - Woodman, Marmaduke
AU  - Woodman M
AD  - Aix Marseille Universite, INS, Institut de Neurosciences des systemes, Marseille, 
      France. Inserm,UMR_S 1106, 13005, Marseille, France.
FAU - Giusiano, Bernard
AU  - Giusiano B
AD  - Aix Marseille Universite, INS, Institut de Neurosciences des systemes, Marseille, 
      France. Inserm,UMR_S 1106, 13005, Marseille, France.
FAU - Jirsa, Viktor
AU  - Jirsa V
AD  - Aix Marseille Universite, INS, Institut de Neurosciences des systemes, Marseille, 
      France. Inserm,UMR_S 1106, 13005, Marseille, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160804
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Mapping/methods
MH  - Electroencephalography/*methods
MH  - Evoked Potentials
MH  - Female
MH  - Humans
MH  - Male
MH  - Parietal Lobe/physiology
MH  - Rest
MH  - Transcranial Magnetic Stimulation/*methods
MH  - Young Adult
PMC - PMC4973226
EDAT- 2016/08/05 06:00
MHDA- 2018/05/03 06:00
PMCR- 2016/08/04
CRDT- 2016/08/05 06:00
PHST- 2016/04/04 00:00 [received]
PHST- 2016/07/14 00:00 [accepted]
PHST- 2016/08/05 06:00 [entrez]
PHST- 2016/08/05 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
PHST- 2016/08/04 00:00 [pmc-release]
AID - srep31220 [pii]
AID - 10.1038/srep31220 [doi]
PST - epublish
SO  - Sci Rep. 2016 Aug 4;6:31220. doi: 10.1038/srep31220.