PMID- 27488537
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180718
LR  - 20180718
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 8
IP  - 33
DP  - 2016 Aug 24
TI  - Diffusion-Induced Hydrophilic Conversion of Polydimethylsiloxane/Block-Type 
      Phospholipid Polymer Hybrid Substrate for Temporal Cell-Adhesive Surface.
PG  - 21839-46
LID - 10.1021/acsami.6b07414 [doi]
AB  - In this study, diffusion-induced hydrophobic-hydrophilic conversion of the 
      surface of the cross-linked polydimethylsiloxane (PDMS) substrate was realized by 
      employing a simple swelling-deswelling process of PDMS substrate in a block-type 
      polymer solution with the aim of development of a temporal cell-adhesive 
      substrate. The ABA block-type polymer composed of poly(2-methacryloyloxyethyl 
      phosphorylcholine) (PMPC) segment and PDMS segment with over 70% of 
      dimethylsiloxane unit composition could be successfully incorporated in the PDMS 
      substrate during the swelling-deswelling process to prepare the PDMS/phospholipid 
      block copolymer hybrid substrates. During the aging process of the PDMS substrate 
      for 4 days in aqueous medium, its surface property changed gradually from 
      hydrophobic to hydrophilic. X-ray photoelectron spectroscopy and atomic force 
      microscopy data provided strong evidence that the time-dependent hydrophilic 
      conversion of the PDMS/block-type phospholipid polymer hybrid substrate was 
      induced by the diffusion of the hydrophilic PMPC segment in the block-type 
      polymer to be tethered on the substrate. During the hydrophilic conversion 
      process, surface-adsorbed fibronectin was gradually desorbed from the substrate 
      surface, and this resulted in successful detachment of two-dimensional connected 
      cell crowds.
FAU - Seo, Ji-Hun
AU  - Seo JH
AD  - Department of Materials Engineering, School of Engineering, University of Tokyo , 
      7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
AD  - Department of Materials Science and Engineering, School of Engineering, Korea 
      University , 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
FAU - Ishihara, Kazuhiko
AU  - Ishihara K
AD  - Department of Materials Engineering, School of Engineering, University of Tokyo , 
      7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160812
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
OTO - NOTNLM
OT  - cell adhesion
OT  - hybrid material
OT  - poly(2-methacryloyloxyethyl phosphorylcholine)
OT  - polydimethylsiloxane
OT  - swelling-deswelling process
EDAT- 2016/08/05 06:00
MHDA- 2016/08/05 06:01
CRDT- 2016/08/05 06:00
PHST- 2016/08/05 06:00 [entrez]
PHST- 2016/08/05 06:00 [pubmed]
PHST- 2016/08/05 06:01 [medline]
AID - 10.1021/acsami.6b07414 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2016 Aug 24;8(33):21839-46. doi: 
      10.1021/acsami.6b07414. Epub 2016 Aug 12.