PMID- 27488607
OWN - NLM
STAT- MEDLINE
DCOM- 20170310
LR  - 20221207
IS  - 1744-7666 (Electronic)
IS  - 1465-6566 (Linking)
VI  - 17
IP  - 14
DP  - 2016 Oct
TI  - Statins worsen glycemic control of T2DM in target LDL-c level and LDL-c reduction 
      dependent manners: a meta-analysis.
PG  - 1839-49
LID - 10.1080/14656566.2016.1220539 [doi]
AB  - OBJECTIVE: Recent studies demonstrated that a low target low-density lipoprotein 
      cholesterol (LDL-c) level, high LDL-c reduction and high dose of statin therapy 
      increased incident diabetes. This study aimed to explore how statin therapy 
      influences glycemic control in type 2 diabetes mellitus (T2DM). METHODS: Medline, 
      Embase, and Cochrane Central were searched for randomized control trials inT2DM. 
      Trials with target LDL-c levels of </=2.6 mmol/L or LDL-c reduction of >/=30% were 
      analyzed. Then, we calculated mean differences in glycosylated hemoglobin (HbA1c) 
      and fasting blood glucose via stratified LDL-c level, relative LDL-c reduction 
      and statin dose. RESULTS: In total, trials involving 6,875 participants (3,619 
      statins, 3,256 controls) were included. Meta-analysis showed that detrimental 
      effect of intensive LDL-c lowering statin therapy on HbA1c (SMD 0.10%; 95% CI 
      0.05, 0.15; p = 0.000) was more severe than all statin trials analyzed together 
      (SMD 0.07%; 95% CI 0.02, 0.12; p = 0.005). Stratified analyses revealed that the 
      effects on HbA1c became increasingly significant as target LDL-c level decreased 
      and LDL-c reduction increased. Low baseline LDL-c and endpoint LDL-c levels were 
      risk factors involved in increasing HbA1c level during statin therapy. 
      CONCLUSIONS: Statin therapy worsens the glycemic control of T2DM in target LDL-c 
      level and LDL-c reduction dependent manners.
FAU - Cai, Rongrong
AU  - Cai R
AD  - a Department of Endocrinology , The Affiliated ZhongDa Hospital of Southeast 
      University , Nanjing , PR China.
AD  - b Medical School of Southeast University , Nanjing , PR China.
FAU - Yuan, Yang
AU  - Yuan Y
AD  - a Department of Endocrinology , The Affiliated ZhongDa Hospital of Southeast 
      University , Nanjing , PR China.
FAU - Sun, Jie
AU  - Sun J
AD  - a Department of Endocrinology , The Affiliated ZhongDa Hospital of Southeast 
      University , Nanjing , PR China.
FAU - Xia, Wenqing
AU  - Xia W
AD  - a Department of Endocrinology , The Affiliated ZhongDa Hospital of Southeast 
      University , Nanjing , PR China.
FAU - Huang, Rong
AU  - Huang R
AD  - a Department of Endocrinology , The Affiliated ZhongDa Hospital of Southeast 
      University , Nanjing , PR China.
FAU - Tian, Sai
AU  - Tian S
AD  - a Department of Endocrinology , The Affiliated ZhongDa Hospital of Southeast 
      University , Nanjing , PR China.
FAU - Dong, Xue
AU  - Dong X
AD  - a Department of Endocrinology , The Affiliated ZhongDa Hospital of Southeast 
      University , Nanjing , PR China.
FAU - Shen, Yanjue
AU  - Shen Y
AD  - a Department of Endocrinology , The Affiliated ZhongDa Hospital of Southeast 
      University , Nanjing , PR China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - a Department of Endocrinology , The Affiliated ZhongDa Hospital of Southeast 
      University , Nanjing , PR China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20160812
PL  - England
TA  - Expert Opin Pharmacother
JT  - Expert opinion on pharmacotherapy
JID - 100897346
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Blood Glucose/drug effects
MH  - Cholesterol, LDL/*blood
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects/therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
OTO - NOTNLM
OT  - Diabetes
OT  - HbA1c
OT  - LDL-c
OT  - meta-analysis
OT  - statins
EDAT- 2016/08/05 06:00
MHDA- 2017/03/11 06:00
CRDT- 2016/08/05 06:00
PHST- 2016/08/05 06:00 [entrez]
PHST- 2016/08/05 06:00 [pubmed]
PHST- 2017/03/11 06:00 [medline]
AID - 10.1080/14656566.2016.1220539 [doi]
PST - ppublish
SO  - Expert Opin Pharmacother. 2016 Oct;17(14):1839-49. doi: 
      10.1080/14656566.2016.1220539. Epub 2016 Aug 12.