PMID- 2748873
OWN - NLM
STAT- MEDLINE
DCOM- 19890821
LR  - 20190908
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 13
IP  - 3-4
DP  - 1989
TI  - Common side effects associated with monoamine oxidase inhibitors.
PG  - 497-504
AB  - There is relatively little documentation on the common side effects associated 
      with monoamine oxidase inhibitors (MAOI) and their frequency of occurrence. A 
      retrospective chart review of patient records in a Mood Disorders Service was 
      completed. Side effects of patients receiving phenelzine (N = 42) and 
      tranylcypromine (N = 19) were rated as mild (resulting in no change in 
      treatment), moderate (some modification in treatment plan necessary), and severe 
      (definite change in treatment plan or drug discontinuation due to MAOI side 
      effect). A total of 35 reports of side effects were noted in 15 of 19 
      tranylcypromine patients (1.84 per patients) and a total of 125 side effect 
      reports were noted in 39 of 42 phenelzine patients (2.98 per patient). Only two 
      severe tranylcypromine side effects occurred (resulting in drug cessation for one 
      of these patients - hypotension), while 9 severe reactions occurred with 
      phenelzine, resulting in drug discontinuation in 6 of these patients. The side 
      effects for tranylcypromine and the number of reports were insomnia (N = 10), 
      sedation (N = 8), hypotension (N = 5), sexual dysfunction (N = 3), hypomania (N = 
      3), weight gain/edema (N = 2), hypertensive episode (N = 2), and myoclonic 
      jerking (N = 2). The number of reports of phenelzine side effects were insomnia 
      (N = 26), hypomania/mania (N = 27; most common reason for drug cessation - 4), 
      hypotension (N = 16; three cases considered severe), weight gain/edema (N = 15), 
      sedation (N = 15), sexual dysfunction (N = 13), hypertensive episode (N = 6), and 
      myoclonic jerking (N = 7).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Remick, R A
AU  - Remick RA
AD  - Department of Psychiatry, University Hospital - U.B.C. Site, Vancouver, Canada.
FAU - Froese, C
AU  - Froese C
FAU - Keller, F D
AU  - Keller FD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 3E3V44J4Z9 (Tranylcypromine)
RN  - O408N561GF (Phenelzine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bipolar Disorder/*drug therapy
MH  - Depressive Disorder/*drug therapy
MH  - Humans
MH  - Hypotension/chemically induced
MH  - Middle Aged
MH  - Phenelzine/*adverse effects/therapeutic use
MH  - Tranylcypromine/*adverse effects/therapeutic use
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1016/0278-5846(89)90137-1 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(3-4):497-504. doi: 
      10.1016/0278-5846(89)90137-1.