PMID- 27490532
OWN - NLM
STAT- MEDLINE
DCOM- 20170321
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 17
IP  - 8
DP  - 2016 Aug 1
TI  - Serum Concentrations of Endothelin-1 and Matrix Metalloproteinases-2, -9 in 
      Pre-Hypertensive and Hypertensive Patients with Type 2 Diabetes.
LID - 10.3390/ijms17081182 [doi]
LID - 1182
AB  - Endothelin-1 (ET-1) is one of the most potent vasoconstrictors known to date. 
      While its plasma or serum concentrations are elevated in some forms of 
      experimental and human hypertension, this is not a consistent finding in all 
      forms of hypertension. Matrix metalloproteinases -2 and -9 (MMP-2 and MMP-9), 
      which degrade collagen type IV of the vascular basement membrane, are responsible 
      for vascular remodeling, inflammation, and atherosclerotic complications, 
      including in type 2 diabetes (T2D). In our study, we compared concentrations of 
      ET-1, MMP-2, and MMP-9 in pre-hypertensive (PHTN) and hypertensive (HTN) T2D 
      patients with those of healthy normotensive controls (N). ET-1, MMP-2, and MMP-9 
      were measured by ELISA. Concentrations of ET-1 in PHTN and N were very similar, 
      while those in HTN were significantly higher. Concentrations of MMP-2 and MMP-9 
      in PHTN and HTN were also significantly higher compared to N. An interesting 
      result in our study is that concentrations of MMP-2 and MMP-9 in HTN were lower 
      compared to PHTN. In conclusion, we showed that increased production of ET-1 in 
      patients with T2D can lead to long-lasting increases in blood pressure (BP) and 
      clinical manifestation of hypertension. We also demonstrated that increased 
      levels of MMP-2 and MMP-9 in pre-hypertensive and hypertensive patients with T2D 
      mainly reflect the early vascular changes in extracellular matrix (ECM) turnover.
FAU - Kostov, Krasimir
AU  - Kostov K
AD  - Department of Physiology and Pathophysiology, Medical University-Pleven, 1 
      Kliment Ohridski Str., 5800 Pleven, Bulgaria. dr.krasi_kostov@abv.bg.
FAU - Blazhev, Alexander
AU  - Blazhev A
AD  - Division of Biology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 
      Pleven, Bulgaria. yalishanda9@gmail.com.
FAU - Atanasova, Milena
AU  - Atanasova M
AD  - Division of Biology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 
      Pleven, Bulgaria. milenaar2001@yahoo.com.
FAU - Dimitrova, Anelia
AU  - Dimitrova A
AD  - Department of Physiology and Pathophysiology, Medical University-Pleven, 1 
      Kliment Ohridski Str., 5800 Pleven, Bulgaria. anelija.dimitrova@gmail.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160801
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (Endothelin-1)
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*blood
MH  - Blood Pressure
MH  - Bulgaria/epidemiology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*physiopathology
MH  - Endothelin-1/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Hypertension/*blood/diagnosis/*epidemiology
MH  - Male
MH  - Matrix Metalloproteinase 2/*blood
MH  - Matrix Metalloproteinase 9/*blood
MH  - Middle Aged
MH  - Young Adult
PMC - PMC5000590
OTO - NOTNLM
OT  - endothelin-1
OT  - matrix metalloproteinases-2
OT  - matrix metalloproteinases-9
OT  - pre-hypertension
OT  - type 2 diabetes
OT  - vascular remodeling
EDAT- 2016/08/05 06:00
MHDA- 2017/03/23 06:00
PMCR- 2016/08/01
CRDT- 2016/08/05 06:00
PHST- 2016/06/01 00:00 [received]
PHST- 2016/07/07 00:00 [revised]
PHST- 2016/07/13 00:00 [accepted]
PHST- 2016/08/05 06:00 [entrez]
PHST- 2016/08/05 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - ijms17081182 [pii]
AID - ijms-17-01182 [pii]
AID - 10.3390/ijms17081182 [doi]
PST - epublish
SO  - Int J Mol Sci. 2016 Aug 1;17(8):1182. doi: 10.3390/ijms17081182.