PMID- 27491406
OWN - NLM
STAT- MEDLINE
DCOM- 20170330
LR  - 20181202
IS  - 1432-086X (Electronic)
IS  - 0174-1551 (Linking)
VI  - 39
IP  - 10
DP  - 2016 Oct
TI  - Phase I/II Multi-Institutional Study of Percutaneous Radiofrequency Ablation for 
      Painful Osteoid Osteoma (JIVROSG-0704).
PG  - 1464-70
LID - 10.1007/s00270-016-1438-7 [doi]
AB  - PURPOSE: This multicenter prospective study was conducted to evaluate the safety 
      and efficacy of percutaneous radiofrequency ablation (RFA) for painful osteoid 
      osteoma (OO). MATERIALS AND METHODS: Patients with OO (femur: n = 17, tibia: 
      n = 2, humerus: n = 1, rib: n = 1) were enrolled and treated with RFA. In phase 
      I, nine patients were evaluated for safety. In phase II, 12 patients were 
      accrued, and an intent-to-treat analysis was performed on all patients. The 
      primary endpoint was to evaluate the treatment safety. The secondary endpoint was 
      to evaluate the efficacy for pain relief by the visual analogue scale (VAS) at 
      4 weeks after RFA. Treatment efficacy was classified as significantly effective 
      (SE) when VAS score decreased by >/=5 or score was <2, moderately effective when 
      VAS score decreased by <5->/=2 and score was >/=2, and not effective (NE) when VAS 
      score decreased by <2 or score was increased. Cases where the need for analgesics 
      increased after treatment were also NE. RESULTS: RFA procedures were completed in 
      all patients. Minor adverse effects (AEs) were observed as 4.8-14.3 % in 12 
      patients, and no major AEs were observed. Mean VAS score was 7.1 before 
      treatment, 1.6 at 1 week, 0.3 at 4 weeks, and 0.2 at 3 months. All procedures 
      were classified as SE. Pain recurrence was not noted in any patient during 
      follow-up (mean: 15.1 months). CONCLUSION: RFA is a safe, highly effective, and 
      fast-acting treatment for painful extraspinal OO. Future studies with a greater 
      number of patients are needed.
FAU - Miyazaki, Masaya
AU  - Miyazaki M
AD  - Department of Interventional Radiology and Clinical Ultrasound Center, Gunma 
      University Hospital, 3-39-15, Showa-machi, Maebashi, Gunma, 371-8511, Japan. 
      mmiyazak@gunma-u.ac.jp.
FAU - Arai, Yasuaki
AU  - Arai Y
AD  - Division of Diagnostic Radiology, National Center Hospital, 5-1-1, Tsukiji, 
      Chuo-ku, Tokyo, 104-0045, Japan.
FAU - Myoui, Akira
AU  - Myoui A
AD  - Medical Center for Translational Research, Osaka University Hospital, 2-15 
      Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Gobara, Hideo
AU  - Gobara H
AD  - Department of Radiology, Okayama University Medical School, 2-5-1 Shikatacho, 
      Kita-ku, Okayama, 700-8558, Japan.
FAU - Sone, Miyuki
AU  - Sone M
AD  - Division of Diagnostic Radiology, National Center Hospital, 5-1-1, Tsukiji, 
      Chuo-ku, Tokyo, 104-0045, Japan.
FAU - Rosenthal, Daniel I
AU  - Rosenthal DI
AD  - Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 
      55 Fruit Street, Boston, MA, 02114, USA.
FAU - Tsushima, Yoshito
AU  - Tsushima Y
AD  - Department of Interventional Radiology and Clinical Ultrasound Center, Gunma 
      University Hospital, 3-39-15, Showa-machi, Maebashi, Gunma, 371-8511, Japan.
FAU - Kanazawa, Susumu
AU  - Kanazawa S
AD  - Department of Radiology, Okayama University Medical School, 2-5-1 Shikatacho, 
      Kita-ku, Okayama, 700-8558, Japan.
FAU - Ehara, Shigeru
AU  - Ehara S
AD  - Department of Radiology, Iwate Medical University School of Medicine, 19-1 
      Uchimaru, Morioka, 020-8505, Japan.
FAU - Endo, Keigo
AU  - Endo K
AD  - Department of Interventional Radiology and Clinical Ultrasound Center, Gunma 
      University Hospital, 3-39-15, Showa-machi, Maebashi, Gunma, 371-8511, Japan.
LA  - eng
PT  - Clinical Trial, Phase I
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160804
PL  - United States
TA  - Cardiovasc Intervent Radiol
JT  - Cardiovascular and interventional radiology
JID - 8003538
SB  - IM
MH  - Adult
MH  - Bone Neoplasms/pathology/*surgery
MH  - Cancer Pain/pathology/*surgery
MH  - Catheter Ablation/*methods
MH  - Female
MH  - Humans
MH  - Intention to Treat Analysis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/surgery
MH  - Osteoma, Osteoid/pathology/*surgery
MH  - Pain Measurement
MH  - Postoperative Complications/etiology
MH  - Prospective Studies
MH  - Tomography, X-Ray Computed/methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Clinical trial
OT  - Osteoid osteoma
OT  - Radiofrequency ablation
EDAT- 2016/08/06 06:00
MHDA- 2017/03/31 06:00
CRDT- 2016/08/06 06:00
PHST- 2016/06/20 00:00 [received]
PHST- 2016/07/26 00:00 [accepted]
PHST- 2016/08/06 06:00 [entrez]
PHST- 2016/08/06 06:00 [pubmed]
PHST- 2017/03/31 06:00 [medline]
AID - 10.1007/s00270-016-1438-7 [pii]
AID - 10.1007/s00270-016-1438-7 [doi]
PST - ppublish
SO  - Cardiovasc Intervent Radiol. 2016 Oct;39(10):1464-70. doi: 
      10.1007/s00270-016-1438-7. Epub 2016 Aug 4.