PMID- 27491532
OWN - NLM
STAT- MEDLINE
DCOM- 20170904
LR  - 20220409
IS  - 1472-1465 (Electronic)
IS  - 0007-1250 (Print)
IS  - 0007-1250 (Linking)
VI  - 209
IP  - 5
DP  - 2016 Nov
TI  - Longitudinal course of behavioural and psychological symptoms of dementia: 
      systematic review.
PG  - 366-377
AB  - BACKGROUND: More information about the pattern of behavioural and psychological 
      symptoms of dementia (BPSD) in the course of dementia is needed to inform 
      patients and clinicians and to design future interventions. AIMS: To determine 
      the persistence and incidence of BPSD and their relation to cognitive function, 
      in individuals with dementia or in cohorts investigated for dementia onset. 
      METHOD: A systematic literature review analysed the baseline prevalence, 
      persistence and incidence of 11 symptoms. The review was conducted according to 
      established guidelines with the exception that we could not exclude the 
      possibilities of bias in the studies examined. RESULTS: The 59 included studies 
      showed considerable heterogeneity in their objectives and methods. The symptoms 
      hyperactivity and apathy showed high persistence and incidence; depression and 
      anxiety low or moderate persistence and moderate incidence; and psychotic 
      symptoms low persistence with moderate or low incidence. CONCLUSIONS: Despite 
      heterogeneity across studies in terms of setting, focus and length of follow-up, 
      there were clinically relevant differences in the longitudinal courses of 
      different BPSD. Apathy was the only symptom with high baseline prevalence, 
      persistence and incidence during the course of dementia.
CI  - (c) The Royal College of Psychiatrists 2016.
FAU - van der Linde, Rianne M
AU  - van der Linde RM
AD  - Rianne M. van der Linde, PhD, Institute of Public Health, University of 
      Cambridge; Tom Dening, FRCPsych, Institute of Mental Health, University of 
      Nottingham; Blossom C. M. Stephan, PhD, Institute of Health and Society, 
      Newcastle University; A. Matthew Prina, PhD, Institute of Psychiatry, King's 
      College London; Elizabeth Evans, PhD, Institute of Health and Society, Newcastle 
      University; Carol Brayne, MD, Institute of Public Health, University of 
      Cambridge, UK rmv23@medschl.cam.ac.uk.
FAU - Dening, Tom
AU  - Dening T
AD  - Rianne M. van der Linde, PhD, Institute of Public Health, University of 
      Cambridge; Tom Dening, FRCPsych, Institute of Mental Health, University of 
      Nottingham; Blossom C. M. Stephan, PhD, Institute of Health and Society, 
      Newcastle University; A. Matthew Prina, PhD, Institute of Psychiatry, King's 
      College London; Elizabeth Evans, PhD, Institute of Health and Society, Newcastle 
      University; Carol Brayne, MD, Institute of Public Health, University of 
      Cambridge, UK.
FAU - Stephan, Blossom C M
AU  - Stephan BC
AD  - Rianne M. van der Linde, PhD, Institute of Public Health, University of 
      Cambridge; Tom Dening, FRCPsych, Institute of Mental Health, University of 
      Nottingham; Blossom C. M. Stephan, PhD, Institute of Health and Society, 
      Newcastle University; A. Matthew Prina, PhD, Institute of Psychiatry, King's 
      College London; Elizabeth Evans, PhD, Institute of Health and Society, Newcastle 
      University; Carol Brayne, MD, Institute of Public Health, University of 
      Cambridge, UK.
FAU - Prina, A Matthew
AU  - Prina AM
AD  - Rianne M. van der Linde, PhD, Institute of Public Health, University of 
      Cambridge; Tom Dening, FRCPsych, Institute of Mental Health, University of 
      Nottingham; Blossom C. M. Stephan, PhD, Institute of Health and Society, 
      Newcastle University; A. Matthew Prina, PhD, Institute of Psychiatry, King's 
      College London; Elizabeth Evans, PhD, Institute of Health and Society, Newcastle 
      University; Carol Brayne, MD, Institute of Public Health, University of 
      Cambridge, UK.
FAU - Evans, Elizabeth
AU  - Evans E
AD  - Rianne M. van der Linde, PhD, Institute of Public Health, University of 
      Cambridge; Tom Dening, FRCPsych, Institute of Mental Health, University of 
      Nottingham; Blossom C. M. Stephan, PhD, Institute of Health and Society, 
      Newcastle University; A. Matthew Prina, PhD, Institute of Psychiatry, King's 
      College London; Elizabeth Evans, PhD, Institute of Health and Society, Newcastle 
      University; Carol Brayne, MD, Institute of Public Health, University of 
      Cambridge, UK.
FAU - Brayne, Carol
AU  - Brayne C
AD  - Rianne M. van der Linde, PhD, Institute of Public Health, University of 
      Cambridge; Tom Dening, FRCPsych, Institute of Mental Health, University of 
      Nottingham; Blossom C. M. Stephan, PhD, Institute of Health and Society, 
      Newcastle University; A. Matthew Prina, PhD, Institute of Psychiatry, King's 
      College London; Elizabeth Evans, PhD, Institute of Health and Society, Newcastle 
      University; Carol Brayne, MD, Institute of Public Health, University of 
      Cambridge, UK.
LA  - eng
GR  - MR/K021907/1/MRC_/Medical Research Council/United Kingdom
GR  - MRC RG56433/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20160804
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
SB  - IM
MH  - Behavioral Symptoms/epidemiology/etiology/*physiopathology
MH  - Dementia/complications/epidemiology/*physiopathology
MH  - *Disease Progression
MH  - Humans
PMC - PMC5100633
COIS- Declaration of interest None.
EDAT- 2016/11/03 06:00
MHDA- 2017/09/05 06:00
PMCR- 2016/11/01
CRDT- 2016/08/06 06:00
PHST- 2014/03/18 00:00 [received]
PHST- 2016/02/27 00:00 [accepted]
PHST- 2016/11/03 06:00 [pubmed]
PHST- 2017/09/05 06:00 [medline]
PHST- 2016/08/06 06:00 [entrez]
PHST- 2016/11/01 00:00 [pmc-release]
AID - S0007125000245376 [pii]
AID - 10.1192/bjp.bp.114.148403 [doi]
PST - ppublish
SO  - Br J Psychiatry. 2016 Nov;209(5):366-377. doi: 10.1192/bjp.bp.114.148403. Epub 
      2016 Aug 4.