PMID- 27493197
OWN - NLM
STAT- MEDLINE
DCOM- 20171211
LR  - 20180920
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 121
IP  - 3
DP  - 2016 Sep 1
TI  - No difference in exogenous carbohydrate oxidation during exercise in children 
      with and without impaired glucose tolerance.
PG  - 724-9
LID - 10.1152/japplphysiol.00419.2016 [doi]
AB  - The capacity to match carbohydrate (CHO) utilization with availability is 
      impaired in insulin-resistant, obese adults at rest. Understanding exogenous 
      carbohydrate (CHOexo) oxidation during exercise and its association to insulin 
      resistance (IR) is important, especially in children at risk for type 2 diabetes. 
      Our objective was to examine the oxidative efficiency of CHOexo during exercise 
      in obese children with normal glucose tolerance (NGT) or impaired glucose 
      tolerance (IGT). Children attended two visits and were identified as NGT (n = 22) 
      or IGT (n = 12) based on 2-h oral glucose tolerance test (OGTT) glucose levels of 
      <7.8 mmol/l or >/=7.8 mmol/l, respectively. Anthropometry, body composition, and 
      aerobic fitness (V̇o2max) were assessed. Insulin and glucose at baseline, 30, 60, 
      90, and 120 min during the OGTT were used to calculate measures of insulin 
      sensitivity. On a separate day, a (13)C-enriched CHO drink was ingested before 
      exercise (3 x 20 min bouts) at 45% V̇o2max Breath measurements were collected to 
      calculate CHOexo oxidative efficiency. CHOexo oxidative efficiency during 
      exercise was similar in IGT (17.0 +/- 3.6%) compared with NGT (17.1 +/- 4.4%) (P = 
      0.90) despite lower whole body insulin sensitivity in IGT at rest (P = 0.02). 
      Area under the curve for insulin (AUCins) measured at rest during the OGTT was 
      greater in IGT compared with NGT (P = 0.04). The ability of skeletal muscle to 
      utilize CHOexo was not impaired during exercise in children with IGT.
CI  - Copyright (c) 2016 the American Physiological Society.
FAU - Chu, Lisa
AU  - Chu L
AD  - Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster 
      University, Hamilton, Ontario, Canada;
FAU - Morrison, Katherine M
AU  - Morrison KM
AD  - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; and.
FAU - Riddell, Michael C
AU  - Riddell MC
AD  - School of Kinesiology & Health Science, York University, Toronto, Ontario, 
      Canada.
FAU - Raha, Sandeep
AU  - Raha S
AD  - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; and.
FAU - Timmons, Brian W
AU  - Timmons BW
AD  - Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster 
      University, Hamilton, Ontario, Canada; timmonbw@mcmaster.ca.
LA  - eng
GR  - MOP-111230/Canadian Institutes of Health Research/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160804
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Carbohydrate Metabolism
MH  - Child
MH  - *Exercise
MH  - Female
MH  - Glucose/*metabolism
MH  - Glucose Intolerance/*physiopathology
MH  - Humans
MH  - Insulin/*blood
MH  - *Insulin Resistance
MH  - Male
MH  - Oxidation-Reduction
OTO - NOTNLM
OT  - carbohydrate oxidation
OT  - children
OT  - exercise
OT  - obesity
EDAT- 2016/08/06 06:00
MHDA- 2017/12/12 06:00
CRDT- 2016/08/06 06:00
PHST- 2016/05/04 00:00 [received]
PHST- 2016/08/01 00:00 [accepted]
PHST- 2016/08/06 06:00 [entrez]
PHST- 2016/08/06 06:00 [pubmed]
PHST- 2017/12/12 06:00 [medline]
AID - japplphysiol.00419.2016 [pii]
AID - 10.1152/japplphysiol.00419.2016 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2016 Sep 1;121(3):724-9. doi: 
      10.1152/japplphysiol.00419.2016. Epub 2016 Aug 4.