PMID- 27493667
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160805
LR  - 20201001
IS  - 1687-9260 (Print)
IS  - 1687-9279 (Electronic)
IS  - 1687-9260 (Linking)
VI  - 2016
DP  - 2016
TI  - Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness.
PG  - 6402963
LID - 10.1155/2016/6402963 [doi]
LID - 6402963
AB  - Objective. Osteoarthritis (OA) is associated with increased cardiovascular 
      comorbidity and mortality. Evidence is lacking about whether arterial stiffness 
      is involved in OA. The objective of our study was to find out associations 
      between OA, arterial stiffness, and adipokines. Design. Seventy end-stage knee 
      and hip OA patients (age 62 +/- 7 years) and 70 asymptomatic controls (age 60 +/- 7 
      years) were investigated using the applanation tonometry to determine their 
      parameters of arterial stiffness. Serum adiponectin, leptin, and matrix 
      metalloproteinase 3 (MMP-3) levels were determined using the ELISA method. 
      Correlation between variables was determined using Spearman's rho. Multiple 
      regression analysis with a stepwise selection procedure was employed. Results. 
      Radiographic OA grade was positively associated with increased carotid-femoral 
      pulse wave velocity (cf-PWV) (r = 0.272, p = 0.023). We found that OA grade was 
      also associated with leptin and MMP-3 levels (rho = -0.246, p = 0.040 and rho = 
      0.235, p = 0.050, resp.). In addition, serum adiponectin level was positively 
      associated with augmentation index and inversely with large artery elasticity 
      index (rho = 0.293, p = 0.006 and rho = -0.249, p = 0.003, resp.). Conclusions. 
      Our results suggest that OA severity is independently associated with increased 
      arterial stiffness and is correlated with expression of adipokines. Thus, 
      increased arterial stiffness and adipokines might play an important role in 
      elevated cardiovascular risk in end-stage OA.
FAU - Tootsi, Kaspar
AU  - Tootsi K
AUID- ORCID: 0000-0003-2151-9031
AD  - Department of Traumatology and Orthopaedics, University of Tartu, Puusepa Street 
      8, 51014 Tartu, Estonia; Endothelial Centre, University of Tartu, Tartu, Estonia.
FAU - Kals, Jaak
AU  - Kals J
AD  - Endothelial Centre, University of Tartu, Tartu, Estonia; Department of Surgery, 
      University of Tartu, Tartu, Estonia; Institute of Biomedicine and Translational 
      Medicine and Department of Biochemistry, Centre of Excellence for Genomics and 
      Translational Medicine, University of Tartu, Ravila Street 19, 50411 Tartu, 
      Estonia.
FAU - Zilmer, Mihkel
AU  - Zilmer M
AD  - Department of Surgery, University of Tartu, Tartu, Estonia; Institute of 
      Biomedicine and Translational Medicine and Department of Biochemistry, Centre of 
      Excellence for Genomics and Translational Medicine, University of Tartu, Ravila 
      Street 19, 50411 Tartu, Estonia.
FAU - Paapstel, Kaido
AU  - Paapstel K
AD  - Endothelial Centre, University of Tartu, Tartu, Estonia; Institute of Biomedicine 
      and Translational Medicine and Department of Biochemistry, Centre of Excellence 
      for Genomics and Translational Medicine, University of Tartu, Ravila Street 19, 
      50411 Tartu, Estonia.
FAU - Martson, Aare
AU  - Martson A
AD  - Department of Traumatology and Orthopaedics, University of Tartu, Puusepa Street 
      8, 51014 Tartu, Estonia; Traumatology and Orthopaedics Clinic, Tartu University 
      Hospital, Tartu, Estonia.
LA  - eng
PT  - Journal Article
DEP - 20160717
PL  - United States
TA  - Int J Rheumatol
JT  - International journal of rheumatology
JID - 101519204
PMC - PMC4967435
EDAT- 2016/08/06 06:00
MHDA- 2016/08/06 06:01
PMCR- 2016/07/17
CRDT- 2016/08/06 06:00
PHST- 2016/03/05 00:00 [received]
PHST- 2016/06/12 00:00 [accepted]
PHST- 2016/08/06 06:00 [entrez]
PHST- 2016/08/06 06:00 [pubmed]
PHST- 2016/08/06 06:01 [medline]
PHST- 2016/07/17 00:00 [pmc-release]
AID - 10.1155/2016/6402963 [doi]
PST - ppublish
SO  - Int J Rheumatol. 2016;2016:6402963. doi: 10.1155/2016/6402963. Epub 2016 Jul 17.