PMID- 27493760
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160805
LR  - 20210112
IS  - 2053-3624 (Print)
IS  - 2053-3624 (Electronic)
IS  - 2053-3624 (Linking)
VI  - 3
IP  - 2
DP  - 2016
TI  - Sudden cardiac death in adults with congenitally corrected transposition of the 
      great arteries.
PG  - e000407
LID - 10.1136/openhrt-2016-000407 [doi]
LID - e000407
AB  - BACKGROUND: Congenitally corrected transposition of the great arteries (ccTGA) is 
      a rare congenital heart disease. There have been only few reports of sudden 
      cardiac death (SCD) in patients with ccTGA and reasonable ventricular function. 
      METHODS: A retrospective review of the medical records of all patients attending 
      our adult congenital heart centre, with known ccTGA. RESULTS: From a database of 
      over 3500 adult patients with congenital heart disease, we identified 39 ( approximately 1%) 
      with ccTGA and 'two-ventricle' circulations. 65% were male. The mean age at 
      diagnosis was 12.4+/-11.4 years and the mean age at last time of review was 
      34.3+/-11.3 years. 24 patients (56%) had a history of surgical intervention. 8 
      (19%) had had pacemaker implantation and 2 had had a defibrillator implanted for 
      non-sustained ventricular tachycardia (NSVT). In 544 years of patient follow-up, 
      there had been five cases of SCD in our population; 1 death per 109 
      patient-years. Two of these patients had had previously documented 
      supraventricular or NSVT. However, they were all classified as New York Heart 
      Association (NYHA) class I or II, and systemic (right) ventricular function had 
      been recorded as normal, mildly or mildly-moderately impaired, at most recent 
      follow-up. CONCLUSIONS: Our experience suggests the need for improved risk 
      stratification and/or surveillance for malignant arrhythmia in adults with ccTGA, 
      even in those with reasonable functional class on ventricular function.
FAU - McCombe, A
AU  - McCombe A
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, 
      Australia; Discipline of Medicine, Central Clinical School, University of Sydney, 
      Sydney, New South Wales, Australia.
FAU - Touma, F
AU  - Touma F
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, 
      Australia; Discipline of Medicine, Central Clinical School, University of Sydney, 
      Sydney, New South Wales, Australia.
FAU - Jackson, D
AU  - Jackson D
AD  - Department of Cardiology , Royal Prince Alfred Hospital , Sydney, New South Wales 
      , Australia.
FAU - Canniffe, C
AU  - Canniffe C
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, 
      Australia; Department of Cardiology, Mater Misericordiae Hospital, Dublin, 
      Ireland.
FAU - Choudhary, P
AU  - Choudhary P
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, 
      Australia; Discipline of Medicine, Central Clinical School, University of Sydney, 
      Sydney, New South Wales, Australia; Department of Cardiology, Westmead Hospital, 
      Sydney, New South Wales, Australia.
FAU - Pressley, L
AU  - Pressley L
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, 
      Australia; Discipline of Medicine, Central Clinical School, University of Sydney, 
      Sydney, New South Wales, Australia.
FAU - Tanous, D
AU  - Tanous D
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, 
      Australia; Discipline of Medicine, Central Clinical School, University of Sydney, 
      Sydney, New South Wales, Australia; Department of Cardiology, Westmead Hospital, 
      Sydney, New South Wales, Australia.
FAU - Robinson, Peter J
AU  - Robinson PJ
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, 
      Australia; Discipline of Medicine, Central Clinical School, University of Sydney, 
      Sydney, New South Wales, Australia.
FAU - Celermajer, D
AU  - Celermajer D
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, 
      Australia; Discipline of Medicine, Central Clinical School, University of Sydney, 
      Sydney, New South Wales, Australia.
LA  - eng
PT  - Journal Article
DEP - 20160711
PL  - England
TA  - Open Heart
JT  - Open heart
JID - 101631219
PMC - PMC4947757
OTO - NOTNLM
OT  - Cardiac arrhythmias and resuscitation science
OT  - Complex congenital heart disease
EDAT- 2016/08/06 06:00
MHDA- 2016/08/06 06:01
PMCR- 2016/07/11
CRDT- 2016/08/06 06:00
PHST- 2016/01/11 00:00 [received]
PHST- 2016/04/30 00:00 [revised]
PHST- 2016/05/24 00:00 [accepted]
PHST- 2016/08/06 06:00 [entrez]
PHST- 2016/08/06 06:00 [pubmed]
PHST- 2016/08/06 06:01 [medline]
PHST- 2016/07/11 00:00 [pmc-release]
AID - openhrt-2016-000407 [pii]
AID - 10.1136/openhrt-2016-000407 [doi]
PST - epublish
SO  - Open Heart. 2016 Jul 11;3(2):e000407. doi: 10.1136/openhrt-2016-000407. 
      eCollection 2016.