PMID- 27494625
OWN - NLM
STAT- MEDLINE
DCOM- 20170106
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 44
IP  - 3
DP  - 2016 Jul
TI  - Evaluation of non-animal methods for assessing skin sensitisation hazard: A 
      Bayesian Value-of-Information analysis.
PG  - 255-69
AB  - This paper offers a Bayesian Value-of-Information (VOI) analysis for guiding the 
      development of non-animal testing strategies, balancing information gains from 
      testing with the expected social gains and costs from the adoption of regulatory 
      decisions. Testing is assumed to have value, if, and only if, the information 
      revealed from testing triggers a welfare-improving decision on the use (or 
      non-use) of a substance. As an illustration, our VOI model is applied to a set of 
      five individual non-animal prediction methods used for skin sensitisation hazard 
      assessment, seven battery combinations of these methods, and 236 sequential 
      2-test and 3-test strategies. Their expected values are quantified and compared 
      to the expected value of the local lymph node assay (LLNA) as the animal method. 
      We find that battery and sequential combinations of non-animal prediction methods 
      reveal a significantly higher expected value than the LLNA. This holds for the 
      entire range of prior beliefs. Furthermore, our results illustrate that the 
      testing strategy with the highest expected value does not necessarily have to 
      follow the order of key events in the sensitisation adverse outcome pathway 
      (AOP).
CI  - 2016 FRAME.
FAU - Leontaridou, Maria
AU  - Leontaridou M
AD  - Wageningen University, Environmental Economics and Natural Resources Group, 
      Wageningen, The Netherlands and BASF SE, Experimental Toxicology and Ecology, 
      Ludwigshafen, Germany.
FAU - Gabbert, Silke
AU  - Gabbert S
AD  - Wageningen University, Environmental Economics and Natural Resources Group, 
      Wageningen, The Netherlands.
FAU - Van Ierland, Ekko C
AU  - Van Ierland EC
AD  - Wageningen University, Environmental Economics and Natural Resources Group, 
      Wageningen, The Netherlands.
FAU - Worth, Andrew P
AU  - Worth AP
AD  - European Commission, Joint Research Centre, Directorate F - Health, Consumer and 
      Reference Materials, EURL ECVAM, Ispra, Italy.
FAU - Landsiedel, Robert
AU  - Landsiedel R
AD  - BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
RN  - 0 (Cosmetics)
RN  - 0 (Dermatologic Agents)
SB  - IM
MH  - Animal Testing Alternatives/*methods
MH  - Animals
MH  - Bayes Theorem
MH  - Cosmetics/*toxicity
MH  - Databases, Factual
MH  - *Dermatitis, Contact
MH  - Dermatologic Agents/*toxicity
EDAT- 2016/08/06 06:00
MHDA- 2017/01/07 06:00
CRDT- 2016/08/06 06:00
PHST- 2016/08/06 06:00 [entrez]
PHST- 2016/08/06 06:00 [pubmed]
PHST- 2017/01/07 06:00 [medline]
AID - 10.1177/026119291604400309 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2016 Jul;44(3):255-69. doi: 10.1177/026119291604400309.