PMID- 27494818
OWN - NLM
STAT- MEDLINE
DCOM- 20190826
LR  - 20190826
IS  - 1933-0693 (Electronic)
IS  - 0022-3085 (Linking)
VI  - 126
IP  - 6
DP  - 2017 Jun
TI  - Effectiveness of minocycline in acute white matter injury after intracerebral 
      hemorrhage.
PG  - 1855-1862
LID - 10.3171/2016.5.JNS152670 [doi]
AB  - OBJECTIVE Intracerebral hemorrhage (ICH) is a fatal disease with high morbidity 
      and mortality, which may be followed by white matter injury (WMI) due to the 
      local oxidizing reaction induced by iron (Fe). In this study, the authors 
      examined the effect of the tetracycline antibiotic minocycline on Fe-induced WMI 
      and c-Jun N-terminal kinase (JNK) activation in rats. METHODS Thirty-six male 
      Sprague-Dawley rats underwent an intracaudate injection of saline, Fe, or Fe + 
      minocycline. Another 36 rats had an intracaudate injection of autologous blood 
      and were treated with minocycline or vehicle (saline). Biomarkers of both WMI and 
      JNK activation were examined. RESULTS In the Fe-injection group, minocycline 
      suppressed WMI labeled by beta-amyloid precursor protein (beta-APP) and degraded myelin 
      basic protein (dMBP)/MBP ratio. Protein levels of phosphorylated-JNK were 
      increased after Fe injection, and could be suppressed by minocycline treatment. 
      In the autologous blood-injection group, beta-APP and dMBP/MBP levels increased in 
      the ipsilateral site compared with the contralateral site, which could be 
      suppressed by 7 days of minocycline intervention. CONCLUSIONS Iron plays a 
      critical role in WMI after ICH, which can be suppressed by minocycline through 
      reducing the damage induced by Fe.
FAU - Zou, Xiang
AU  - Zou X
AD  - Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Wu, Zehan
AU  - Wu Z
AD  - Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Zhu, Wei
AU  - Zhu W
AD  - Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Chen, Liang
AU  - Chen L
AD  - Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Mao, Ying
AU  - Mao Y
AD  - Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Zhao, Fan
AU  - Zhao F
AD  - Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20160805
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Myelin Basic Protein)
RN  - FYY3R43WGO (Minocycline)
MH  - Amyloid beta-Protein Precursor/metabolism
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology/*therapeutic use
MH  - Cerebral Hemorrhage/*complications/metabolism/pathology
MH  - Disease Models, Animal
MH  - Leukoencephalopathies/*drug therapy/etiology/metabolism/pathology
MH  - Male
MH  - Minocycline/pharmacology/*therapeutic use
MH  - Myelin Basic Protein/metabolism
MH  - Phosphorylation/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - White Matter/*drug effects/metabolism/pathology
OTO - NOTNLM
OT  - APP = amyloid precursor protein
OT  - Fe
OT  - GAPDH = glyceraldehyde 3-phosphate dehydrogenase
OT  - ICH = intracerebral hemorrhage
OT  - JNK = c-Jun N-terminal kinase
OT  - MBP = myelin basic protein
OT  - WMI = white matter injury
OT  - c-Jun N-terminal kinase
OT  - dMBP = degraded MBP
OT  - intracerebral hemorrhage
OT  - iron
OT  - minocycline
OT  - vascular disorders
OT  - white matter injury
EDAT- 2016/08/06 06:00
MHDA- 2019/08/27 06:00
CRDT- 2016/08/06 06:00
PHST- 2016/08/06 06:00 [pubmed]
PHST- 2019/08/27 06:00 [medline]
PHST- 2016/08/06 06:00 [entrez]
AID - 10.3171/2016.5.JNS152670 [doi]
PST - ppublish
SO  - J Neurosurg. 2017 Jun;126(6):1855-1862. doi: 10.3171/2016.5.JNS152670. Epub 2016 
      Aug 5.