PMID- 27496432
OWN - NLM
STAT- MEDLINE
DCOM- 20170412
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 48
IP  - 5
DP  - 2016 Jun
TI  - Impact of Obesity on Renal Graft Function-Analysis of Kidney Grafts From the Same 
      Donor.
PG  - 1482-8
LID - S0041-1345(16)00360-2 [pii]
LID - 10.1016/j.transproceed.2015.12.135 [doi]
AB  - BACKGROUND: The epidemic of obesity has led to dilemmas facing all nephrologists 
      who care for patients with chronic kidney disease and who must make decisions 
      regarding whether or not the patient can undergo transplantation. The aim of the 
      study was to assess the outcome of transplantation among obese compared to 
      nonobese recipients. To minimize donor variability and bias, paired kidney 
      analysis was applied. MATERIALS AND METHODS: Patients with a body mass index >30 
      who received transplants in our unit between January 2000 and December 2010 were 
      selected. For the analysis, only obese transplant recipients (OTR) and their 
      kidney donor pairs with a body mass index <30 (nonobese transplant recipients 
      [NOTR]) were selected. A total of 37 pairs of patients were evaluated in terms of 
      the graft function, patient and graft survival, and number of complications. 
      RESULTS: Groups did not differ with respect to sex and comorbidities. OTR were 
      older than NOTR (53.1 vs 46.02 years old, P < .05). One-year patient and graft 
      survivals were similar (100% vs 97.29% and 100% vs 94.59% in OTR and NOTR, 
      respectively). There were no significant differences between OTR and NOTR with 
      respect to incidence of acute rejection (29.7% vs 18.9%), delayed graft function 
      (35.13% vs 29.72%), and mean serum creatinine and estimated glomerular filtration 
      rate (four-variable Modification of Diet in Renal Disease formula) assessed at 
      discharge and after 3, 6, and 12 months, respectively. OTR had a significantly 
      longer hospitalization time (25.56 vs 20.66 days; P < .05), and more often 
      experienced wound breakdown (32.43% vs 8.1%; P < .05) and new-onset diabetes 
      after transplantation (57.14% vs 6.25%; P < .05). CONCLUSIONS: Obesity did not 
      negatively influence patient and graft survival. Transplantation in obese 
      patients should not be postponed.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Wolyniec, Z
AU  - Wolyniec Z
AD  - Department of Nephrology, Transplantology and Internal Medicine, Medical 
      University of Gdansk, Gdansk, Poland.
FAU - Debska-Slizien, A
AU  - Debska-Slizien A
AD  - Department of Nephrology, Transplantology and Internal Medicine, Medical 
      University of Gdansk, Gdansk, Poland.
FAU - Wolyniec, W
AU  - Wolyniec W
AD  - Department of Occupational, Metabolic and Internal Medicine, Medical University 
      of Gdansk, Gdynia, Poland. Electronic address: wolyniecwojtek@gmail.com.
FAU - Rutkowski, B
AU  - Rutkowski B
AD  - Department of Nephrology, Transplantology and Internal Medicine, Medical 
      University of Gdansk, Gdansk, Poland.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Comorbidity
MH  - Delayed Graft Function/etiology
MH  - Female
MH  - *Graft Survival
MH  - Humans
MH  - Kidney Diseases/epidemiology/surgery
MH  - Kidney Transplantation/*methods
MH  - Male
MH  - Middle Aged
MH  - Obesity/*complications/epidemiology
MH  - *Transplant Recipients
MH  - Young Adult
EDAT- 2016/08/09 06:00
MHDA- 2017/04/13 06:00
CRDT- 2016/08/07 06:00
PHST- 2015/11/30 00:00 [received]
PHST- 2015/12/30 00:00 [accepted]
PHST- 2016/08/07 06:00 [entrez]
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2017/04/13 06:00 [medline]
AID - S0041-1345(16)00360-2 [pii]
AID - 10.1016/j.transproceed.2015.12.135 [doi]
PST - ppublish
SO  - Transplant Proc. 2016 Jun;48(5):1482-8. doi: 10.1016/j.transproceed.2015.12.135.