PMID- 27496657
OWN - NLM
STAT- MEDLINE
DCOM- 20170609
LR  - 20180102
IS  - 1528-1175 (Electronic)
IS  - 0003-3022 (Linking)
VI  - 125
IP  - 5
DP  - 2016 Nov
TI  - Resting-state Network-specific Breakdown of Functional Connectivity during 
      Ketamine Alteration of Consciousness in Volunteers.
PG  - 873-888
AB  - BACKGROUND: Consciousness-altering anesthetic agents disturb connectivity between 
      brain regions composing the resting-state consciousness networks (RSNs). The 
      default mode network (DMn), executive control network, salience network (SALn), 
      auditory network, sensorimotor network (SMn), and visual network sustain 
      mentation. Ketamine modifies consciousness differently from other agents, 
      producing psychedelic dreaming and no apparent interaction with the environment. 
      The authors used functional magnetic resonance imaging to explore 
      ketamine-induced changes in RSNs connectivity. METHODS: Fourteen healthy 
      volunteers received stepwise intravenous infusions of ketamine up to loss of 
      responsiveness. Because of agitation, data from six subjects were excluded from 
      analysis. RSNs connectivity was compared between absence of ketamine (wake state 
      [W1]), light ketamine sedation, and ketamine-induced unresponsiveness (deep 
      sedation [S2]). RESULTS: Increasing the depth of ketamine sedation from W1 to S2 
      altered DMn and SALn connectivity and suppressed the anticorrelated activity 
      between DMn and other brain regions. During S2, DMn connectivity, particularly 
      between the medial prefrontal cortex and the remaining network (effect size beta 
      [95% CI]: W1 = 0.20 [0.18 to 0.22]; S2 = 0.07 [0.04 to 0.09]), and DMn 
      anticorrelated activity (e.g., right sensory cortex: W1 = -0.07 [-0.09 to -0.04]; 
      S2 = 0.04 [0.01 to 0.06]) were broken down. SALn connectivity was nonuniformly 
      suppressed (e.g., left parietal operculum: W1 = 0.08 [0.06 to 0.09]; S2 = 0.05 
      [0.02 to 0.07]). Executive control networks, auditory network, SMn, and visual 
      network were minimally affected. CONCLUSIONS: Ketamine induces specific changes 
      in connectivity within and between RSNs. Breakdown of frontoparietal DMn 
      connectivity and DMn anticorrelation and sensory and SMn connectivity 
      preservation are common to ketamine and propofol-induced alterations of 
      consciousness.
FAU - Bonhomme, Vincent
AU  - Bonhomme V
AD  - From the University Department of Anesthesia and Intensive Care Medicine, CHR 
      Citadelle and CHU University Hospital of Liege, Liege, Belgium (V.B., O.J.); Coma 
      Science Group, GIGA Research, University and CHU University Hospital of Liege, 
      Liege, Belgium (V.B., A.V., A.D., M.-A.B., M.A.B., S.L.); GIGA-Cyclotron Research 
      Center: In Vivo Imaging, University of Liege, Liege, Belgium (A.V., A.D., 
      M.-A.B., M.A.B., A.P., A.S., P.M., S.L.); Departments of Algology and Palliative 
      Care (A.V.), Anesthesia and Intensive Care Medicine (V.B., O.J., P.B., J.F.B.), 
      and Neurology (P.M., S.L.), CHU University Hospital of Liege, Liege, Belgium; 
      Department of Neurology, University of Wisconsin, Madison, Wisconsin (M.B.); 
      Departments of Anesthesia and Intensive Care Medicine (P.B.); Department of 
      Physics and Astronomy, The University of Western Ontario, London, Ontario, Canada 
      (A.S.); and Institut du Cerveau et de la Moelle epiniere - ICM, Hopital 
      Pitie-Salpetriere, Paris, France (A.D.).
FAU - Vanhaudenhuyse, Audrey
AU  - Vanhaudenhuyse A
FAU - Demertzi, Athena
AU  - Demertzi A
FAU - Bruno, Marie-Aurelie
AU  - Bruno MA
FAU - Jaquet, Oceane
AU  - Jaquet O
FAU - Bahri, Mohamed Ali
AU  - Bahri MA
FAU - Plenevaux, Alain
AU  - Plenevaux A
FAU - Boly, Melanie
AU  - Boly M
FAU - Boveroux, Pierre
AU  - Boveroux P
FAU - Soddu, Andrea
AU  - Soddu A
FAU - Brichant, Jean Francois
AU  - Brichant JF
FAU - Maquet, Pierre
AU  - Maquet P
FAU - Laureys, Steven
AU  - Laureys S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Anesthesiology
JT  - Anesthesiology
JID - 1300217
RN  - 0 (Anesthetics, Dissociative)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
CIN - Anesthesiology. 2016 Nov;125(5):830-831. PMID: 27483123
MH  - Adult
MH  - Anesthetics, Dissociative/*pharmacology
MH  - Brain/*diagnostic imaging/*drug effects
MH  - Consciousness/*drug effects
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Ketamine/*pharmacology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/diagnostic imaging/drug effects
MH  - Reference Values
MH  - Rest
MH  - Young Adult
EDAT- 2016/10/19 06:00
MHDA- 2017/06/10 06:00
CRDT- 2016/08/07 06:00
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2017/06/10 06:00 [medline]
PHST- 2016/08/07 06:00 [entrez]
AID - 10.1097/ALN.0000000000001275 [doi]
PST - ppublish
SO  - Anesthesiology. 2016 Nov;125(5):873-888. doi: 10.1097/ALN.0000000000001275.