PMID- 27496715
OWN - NLM
STAT- MEDLINE
DCOM- 20180122
LR  - 20181113
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 68
DP  - 2017 Mar
TI  - Early-life exposures to persistent organic pollutants in relation to overweight 
      in preschool children.
PG  - 145-153
LID - S0890-6238(16)30310-0 [pii]
LID - 10.1016/j.reprotox.2016.08.002 [doi]
AB  - Current knowledge on obesogenic effects of persistent organic pollutants (POPs) 
      is equivocal. We therefore evaluated the associations between early-life POP 
      exposures and body mass index (BMI) in 444 Faroese children born in 2007-2009. 
      POPs were measured in maternal 2-week postpartum serum and child age-5 serum. 
      Linear regression and generalised linear models assessed the associations with 
      continuous and dichotomous BMI z-scores, respectively, at ages 18 months and/or 5 
      years. Maternal serum concentrations of HCB, PFOS and PFOA were associated with 
      increased BMI z-scores and/or overweight risk (i.e. BMI z-score>/=85th WHO 
      percentile). No clear association was found for maternal serum-PCBs, p,p'-DDE, 
      PFHxS, PFNA and PFDA. In cross-sectional analyses, we observed a pattern of 
      inverse associations between child serum-POPs and BMI z-scores at age 5, perhaps 
      due to reverse causation that requires attention in future prospective analyses. 
      Findings in this recent cohort support a role of maternal exposure to endocrine 
      disruptors in the childhood obesity epidemic.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Karlsen, Martina
AU  - Karlsen M
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States; Department of Environmental Medicine, Institute of 
      Public Health, University of Southern Denmark, Odense, Denmark.
FAU - Grandjean, Philippe
AU  - Grandjean P
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States; Department of Environmental Medicine, Institute of 
      Public Health, University of Southern Denmark, Odense, Denmark. Electronic 
      address: pgrand@hsph.harvard.edu.
FAU - Weihe, Pal
AU  - Weihe P
AD  - Department of Environmental Medicine, Institute of Public Health, University of 
      Southern Denmark, Odense, Denmark; Department of Occupational Medicine and Public 
      Health, The Faroese Hospital System, Torshavn, Faroe Islands.
FAU - Steuerwald, Ulrike
AU  - Steuerwald U
AD  - Department of Occupational Medicine and Public Health, The Faroese Hospital 
      System, Torshavn, Faroe Islands.
FAU - Oulhote, Youssef
AU  - Oulhote Y
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States.
FAU - Valvi, Damaskini
AU  - Valvi D
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States.
LA  - eng
GR  - R01 ES012199/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160803
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Anthropometry
MH  - Child, Preschool
MH  - Denmark/epidemiology
MH  - Endocrine Disruptors/blood/*toxicity
MH  - Environmental Exposure/*adverse effects/analysis
MH  - Female
MH  - Fluorocarbons/blood/*toxicity
MH  - Humans
MH  - Infant
MH  - Overweight/blood/*chemically induced/epidemiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/blood/*chemically induced/epidemiology
MH  - Prevalence
PMC - PMC5290287
MID - NIHMS809328
OTO - NOTNLM
OT  - Childhood obesity
OT  - DOHaD
OT  - Developmental toxicity
OT  - Endocrine disruptors
OT  - Perfluoroalkyl substances
OT  - Persistent organic pollutants
COIS- Conflict of interest: The authors have no competing interests to declare, 
      financial or otherwise.
EDAT- 2016/08/09 06:00
MHDA- 2018/01/23 06:00
PMCR- 2018/03/01
CRDT- 2016/08/07 06:00
PHST- 2016/05/01 00:00 [received]
PHST- 2016/07/29 00:00 [revised]
PHST- 2016/08/02 00:00 [accepted]
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2018/01/23 06:00 [medline]
PHST- 2016/08/07 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - S0890-6238(16)30310-0 [pii]
AID - 10.1016/j.reprotox.2016.08.002 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2017 Mar;68:145-153. doi: 10.1016/j.reprotox.2016.08.002. Epub 
      2016 Aug 3.