PMID- 27497102
OWN - NLM
STAT- MEDLINE
DCOM- 20171003
LR  - 20180221
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 222
DP  - 2016 Nov 1
TI  - Age-dependent impact of new ESC-Guideline recommended door-to-balloon times on 
      mid-term survival in acute ST-elevation myocardial infarction patients undergoing 
      primary percutaneous coronary intervention.
PG  - 242-246
LID - S0167-5273(16)31618-7 [pii]
LID - 10.1016/j.ijcard.2016.07.224 [doi]
AB  - BACKGROUND: To investigate the age-dependent impact of the superfast 
      door-to-balloon (D2B) times of </=60min as recommended by the new ESC Guideline for 
      patients with ST elevation myocardial infarction (STEMI) undergoing primary 
      percutaneous coronary intervention (PPCI) on mid-term survival rates based on a 
      single center registry dataset. PATIENTS AND METHODS: This study enrolled 
      consecutive STEMI patients who underwent PPCI from Jan 1, 2009 through Sep 30, 
      2013. We compared demographics, clinical characteristics and the D2B-survival 
      relationships between patients aged >/=65 and <65. RESULTS: The younger group 
      comprised 242 patients (68%) aged <65 and the elder group consisted of 115 
      patients (32%) aged >/=65. In patients aged <65, the mortality rate decreased 
      linearly with D2B time shortening (>90min vs. 61-90min vs. </=60min=14.9% vs. 13.3% 
      vs. 1.2%, P=0.001). Contrarily, shortening of D2B time was not associated with 
      reduced mortality rate in patients aged >/=65 (>90min vs. 61-90min vs. </=60min=23.5% 
      vs. 19% vs. 18.9%, P=0.99). In younger patients but not the elderly, a D2B time 
      of <60min has sufficient power to predict mortality with a sensitivity of 0.83, 
      specificity of 0.74, and Youden index of 0.57. CONCLUSIONS: Our results show that 
      the new ESC Guideline recommendation of D2B time </=60min is associated with better 
      survival rates in younger STEMI patients undergoing PPCI. Our findings stress the 
      importance of guideline adherence to minimize reperfusion delay to improve 
      survival in these patients.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Wang, Yu-Chen
AU  - Wang YC
AD  - Graduate Institute of Clinical Medical Science, China Medical University, 
      Taichung 40402, Taiwan; Division of Cardiovascular Medicine, China Medical 
      University Hospital, Taichung 40447, Taiwan; Cardiovascular Research Laboratory, 
      China Medical University Hospital; Division of Cardiovascular Medicine, Asia 
      University Hospital, Taichung 41354, Taiwan.
FAU - Huang, Ying-Ying
AU  - Huang YY
AD  - Division of Cardiovascular Medicine, China Medical University Hospital, Taichung 
      40447, Taiwan.
FAU - Lo, Ping-Hang
AU  - Lo PH
AD  - Division of Cardiovascular Medicine, China Medical University Hospital, Taichung 
      40447, Taiwan.
FAU - Chang, Kuan-Cheng
AU  - Chang KC
AD  - Graduate Institute of Clinical Medical Science, China Medical University, 
      Taichung 40402, Taiwan; Division of Cardiovascular Medicine, China Medical 
      University Hospital, Taichung 40447, Taiwan; Cardiovascular Research Laboratory, 
      China Medical University Hospital. Electronic address: kuancheng.chang@gmail.com.
FAU - Chen, Chu-Huang
AU  - Chen CH
AD  - Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 
      80780, Taiwan; Center for Lipid Biosciences, Kaohsiung Medical University 
      Hospital, Kaohsiung 80780, Taiwan; Vascular and Medicinal Research, Texas Heart 
      Institute, Houston 77030, TX, USA.
FAU - Chen, Ming-Fong
AU  - Chen MF
AD  - Division of Cardiovascular Medicine, China Medical University Hospital, Taichung 
      40447, Taiwan; Cardiovascular Research Laboratory, China Medical University 
      Hospital.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160730
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Angioplasty, Balloon, Coronary/mortality/*standards
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/mortality/standards
MH  - Practice Guidelines as Topic/*standards
MH  - Prospective Studies
MH  - ST Elevation Myocardial Infarction/diagnosis/mortality/*therapy
MH  - Survival Rate/trends
MH  - Time-to-Treatment/*standards
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Percutaneous coronary intervention
OT  - Quality and outcomes of care
EDAT- 2016/08/09 06:00
MHDA- 2017/10/04 06:00
CRDT- 2016/08/07 06:00
PHST- 2016/05/22 00:00 [received]
PHST- 2016/07/29 00:00 [accepted]
PHST- 2016/08/07 06:00 [entrez]
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2017/10/04 06:00 [medline]
AID - S0167-5273(16)31618-7 [pii]
AID - 10.1016/j.ijcard.2016.07.224 [doi]
PST - ppublish
SO  - Int J Cardiol. 2016 Nov 1;222:242-246. doi: 10.1016/j.ijcard.2016.07.224. Epub 
      2016 Jul 30.