PMID- 27498215 OWN - NLM STAT- MEDLINE DCOM- 20171030 LR - 20220410 IS - 1096-0023 (Electronic) IS - 1043-4666 (Linking) VI - 86 DP - 2016 Oct TI - Adiponectin, TNF-alpha and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis. PG - 100-109 LID - S1043-4666(16)30156-9 [pii] LID - 10.1016/j.cyto.2016.06.028 [doi] AB - AIMS: There has been growing evidence that adiponectin, tumor necrosis factor-alpha (TNF-alpha) and inflammatory cytokines involved in insulin resistance and may be attractive candidates for assessing risk of the incident type 2 diabetes (T2DM). A systematic review and meta-analysis of prospective studies was conducted to assess the associations of levels of serum adiponectin, TNF-alpha and inflammatory markers (Interleukin-1 beta (IL-1beta), Interleukin-6 (IL-6), Interleukin-18 (IL-18), C-reactive protein (CRP)) with risk of T2DM. MATERIALS/METHODS: We searched PubMed, ISI Web of Knowledge, EMBASE, and Cochrane Library databases up until February 1, 2016 for eligible studies which were matched to search subjects. Either fixed-effects or random-effects models were used to estimate the summary risk incorporated between study variations. RESULTS: 19 studies comprising a total of 39,136 participants and 7924 cases were included in the meta-analysis. Our findings showed that an obvious association of elevated CRP levels with T2DM risk (relative risk [RR] 1.48 [95% CI 1.26-1.71]), with the absence of publication bias. For IL-6, the meta-analysis involved 16 cohorts with a total of 24,929 participants and 4751 cases. Using data from all trials, a strong positive correlation (1.32 [1.14, 1.51]) was observed between basal plasma IL-6 and T2DM, whereas relatively lower relation between TNF-alpha (1.16 [0.87, 1.45]), IL-18 (1.45 [1.16, 1.73]), IL-1beta (0.87, [0.59, 1.15]) and independently increased risk to occurrence of T2DM. Conversely, we also found that the level of adiponectin decreased significantly in patients with T2DM. Sensitivity analyses further supported the associations. CONCLUSIONS: This meta-analysis indicates that T2DM risk as whole was strongly associated with elevated levels of inflammatory cytokines (IL-1beta, IL-6, IL-18, CRP), TNF-alpha and low levels of adiponectin. Despite an overall detectable association in the meta-analysis, considerable heterogeneity existed between studies. Further work is needed, it seems clear that a complex interplay of inflammation and the development of DM. Moreover, these biomarkers are predictors of T2DM subjects and should take more attention to measure levels of these as well as to target therapy/interventions. CI - Copyright (c) 2016 Elsevier Ltd. All rights reserved. FAU - Liu, Chenxiao AU - Liu C AD - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: 670769638@qq.com. FAU - Feng, Xiu AU - Feng X AD - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: 497085717@qq.com. FAU - Li, Qi AU - Li Q AD - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: 1506594326@qq.com. FAU - Wang, Ying AU - Wang Y AD - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: 1172068544@qq.com. FAU - Li, Qian AU - Li Q AD - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: shygu@njmu.edu.cn. FAU - Hua, Majian AU - Hua M AD - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: majianhua@china.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20160804 PL - England TA - Cytokine JT - Cytokine JID - 9005353 RN - 0 (Adiponectin) RN - 0 (Cytokines) RN - 0 (IL18 protein, human) RN - 0 (IL6 protein, human) RN - 0 (Inflammation Mediators) RN - 0 (Interleukin-18) RN - 0 (Interleukin-1beta) RN - 0 (Interleukin-6) RN - 0 (Tumor Necrosis Factor-alpha) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Adiponectin/*blood/immunology MH - Adult MH - Animals MH - C-Reactive Protein MH - Cytokines/*blood/immunology MH - Diabetes Mellitus, Type 2/blood/*immunology MH - Disease Models, Animal MH - Female MH - Humans MH - Inflammation Mediators/*blood/immunology MH - Interleukin-18/blood MH - Interleukin-1beta/blood MH - Interleukin-6/blood MH - Male MH - Mice MH - Middle Aged MH - Models, Statistical MH - Risk Factors MH - Tumor Necrosis Factor-alpha/*blood/immunology MH - Young Adult OTO - NOTNLM OT - Adiponectin OT - Cytokine OT - Inflammation OT - TNF-alpha OT - Type 2 diabetes EDAT- 2016/08/09 06:00 MHDA- 2017/10/31 06:00 CRDT- 2016/08/08 06:00 PHST- 2016/05/26 00:00 [received] PHST- 2016/06/28 00:00 [revised] PHST- 2016/06/29 00:00 [accepted] PHST- 2016/08/08 06:00 [entrez] PHST- 2016/08/09 06:00 [pubmed] PHST- 2017/10/31 06:00 [medline] AID - S1043-4666(16)30156-9 [pii] AID - 10.1016/j.cyto.2016.06.028 [doi] PST - ppublish SO - Cytokine. 2016 Oct;86:100-109. doi: 10.1016/j.cyto.2016.06.028. Epub 2016 Aug 4.