PMID- 27498233
OWN - NLM
STAT- MEDLINE
DCOM- 20170302
LR  - 20171009
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 162
DP  - 2016 Sep
TI  - A comparative study on the nanoparticles for improved drug delivery systems.
PG  - 681-693
LID - S1011-1344(16)30443-2 [pii]
LID - 10.1016/j.jphotobiol.2016.07.037 [doi]
AB  - Nanoparticles have attracted considerable recent interest for diverse biomedical 
      applications because of the unique properties of the nanomaterials. It is already 
      known that one of the major advances in the relative application of nanoparticles 
      is the recognition of the steric stabilization which can increase the particle 
      stability in the biological environment and provide the opportunities of the 
      application of nanoparticles in the development of drug delivery systems (DDSs) 
      for achieving drug targeting and controlled drug release. To facilitate their use 
      in such applications, the appropriate design of surface ligands on these 
      nanoparticles is necessary. In view of these, functionalized nanoparticles 
      through surface modification can be utilized to specifically interact with the 
      target molecules on the cell membrane or intracellular ones. This review briefly 
      presents self-assembled nanoparticles with molecules of therapeutic significance 
      with two strategies. The first strategy attempts to improve the placement of the 
      drugs using conjugating the appropriate ligands or adding targeting moieties to 
      the DDS. The second strategy utilizes trigger-controlled drug-release, which 
      restricts drug release at the targeted site to kill cancer cells by externally 
      controlled mechanisms. Among external stimulations, conveniently light has 
      attracted much interest because it, as an orthogonal external stimulus, gives 
      spatiotemporal control of payload release.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Mahmoodi, Nosrat O
AU  - Mahmoodi NO
AD  - Department of Chemistry, Faculty of Science, University of Guilan, P.O. Box 
      41335-1914, Rasht, Iran. Electronic address: mahmoodi@guilan.ac.ir.
FAU - Ghavidast, Atefeh
AU  - Ghavidast A
AD  - Department of Chemistry, Faculty of Science, University of Guilan, P.O. Box 
      41335-1914, Rasht, Iran.
FAU - Amirmahani, Najmeh
AU  - Amirmahani N
AD  - Department of Chemistry, Faculty of Science, University of Guilan, P.O. Box 
      41335-1914, Rasht, Iran; Environmental Health Engineering Research Center, Kerman 
      University of Medical Sciences, Kerman, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160726
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Magnetite Nanoparticles)
RN  - 7440-57-5 (Gold)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Antineoplastic Agents/chemistry/toxicity
MH  - Apoptosis/drug effects
MH  - Drug Carriers/*chemistry
MH  - Ferrosoferric Oxide/chemistry
MH  - Gold/chemistry
MH  - Humans
MH  - Magnetite Nanoparticles/chemistry
MH  - Nanoparticles/*chemistry
MH  - Porosity
MH  - Silicon Dioxide/chemistry
OTO - NOTNLM
OT  - Cytotoxicity
OT  - Drug delivery
OT  - Nanoparticles
OT  - Photoresponsive nanoparticles
EDAT- 2016/08/09 06:00
MHDA- 2017/03/03 06:00
CRDT- 2016/08/08 06:00
PHST- 2016/06/08 00:00 [received]
PHST- 2016/07/24 00:00 [revised]
PHST- 2016/07/25 00:00 [accepted]
PHST- 2016/08/08 06:00 [entrez]
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
AID - S1011-1344(16)30443-2 [pii]
AID - 10.1016/j.jphotobiol.2016.07.037 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2016 Sep;162:681-693. doi: 
      10.1016/j.jphotobiol.2016.07.037. Epub 2016 Jul 26.