PMID- 27498757
OWN - NLM
STAT- MEDLINE
DCOM- 20180426
LR  - 20220331
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Aug 8
TI  - Post-bronchiolitis wheezing is associated with toll-like receptor 9 rs187084 gene 
      polymorphism.
PG  - 31165
LID - 10.1038/srep31165 [doi]
LID - 31165
AB  - Innate immunity receptors play a critical role in host defence, as well as in 
      allergy and asthma. The aim of this exploratory study was to evaluate whether 
      there are associations between TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or 
      TLR10 rs4129009 polymorphisms and viral findings, clinical characteristics or 
      subsequent wheezing in infants with bronchiolitis. In all, 135 full-term infants 
      were hospitalized for bronchiolitis at age less than 6 months: 129 of them were 
      followed-up until the age of 1.5 years. The outcome measures were repeated 
      wheezing, use of inhaled corticosteroids, atopic dermatitis during the first 1.5 
      years of life and total serum immunoglobulin E (IgE). There were no significant 
      associations between the genotypes or allele frequencies of TLR7 rs179008, TLR8 
      rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and clinical 
      characteristics or the severity of bronchiolitis during hospitalization. During 
      follow-up, repeated wheezing was more common in children with TLR9 rs187084 
      variant genotype CC (30.5%) than in children with TLR9 wild-type genotype TT 
      (12.2%) (p = 0.02, aOR 2.73, 95% CI 1.02-7.29). The TLR10 rs4129009 minor allele 
      G was associated with elevated total serum IgE. TLR9 rs187084 gene polymorphism 
      may be associated with post-bronchiolitis wheezing, and TLR10 rs4129009 gene 
      polymorphism may be associated with atopy.
FAU - Nuolivirta, Kirsi
AU  - Nuolivirta K
AD  - Department of Pediatrics, Seinajoki Central Hospital, Seinajoki, Finland.
FAU - Tormanen, Sari
AU  - Tormanen S
AD  - Center for Child Health Research, Tampere University and University Hospital, 
      Tampere, Finland.
FAU - Terasjarvi, Johanna
AU  - Terasjarvi J
AD  - Department of Medical Microbiology and Immunology, University of Turku, Turku, 
      Finland.
FAU - Vuononvirta, Juho
AU  - Vuononvirta J
AD  - Department of Medical Microbiology and Immunology, University of Turku, Turku, 
      Finland.
FAU - Koponen, Petri
AU  - Koponen P
AD  - Center for Child Health Research, Tampere University and University Hospital, 
      Tampere, Finland.
FAU - Korppi, Matti
AU  - Korppi M
AD  - Center for Child Health Research, Tampere University and University Hospital, 
      Tampere, Finland.
FAU - Helminen, Merja
AU  - Helminen M
AD  - Center for Child Health Research, Tampere University and University Hospital, 
      Tampere, Finland.
FAU - Peltola, Ville
AU  - Peltola V
AD  - Department of Pediatrics and Adolescent Medicine, Turku University Hospital and 
      Child and Youth Research Institute, University of Turku, Turku, Finland.
FAU - He, Qiushui
AU  - He Q
AD  - Department of Medical Microbiology and Immunology, University of Turku, Turku, 
      Finland.
AD  - Department of Medical Microbiology, Capital Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20160808
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (TLR9 protein, human)
RN  - 0 (Toll-Like Receptor 9)
SB  - IM
MH  - Bronchiolitis/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Respiratory Sounds/*genetics
MH  - Toll-Like Receptor 9/*genetics
PMC - PMC4976338
EDAT- 2016/08/09 06:00
MHDA- 2018/04/27 06:00
PMCR- 2016/08/08
CRDT- 2016/08/09 06:00
PHST- 2016/02/01 00:00 [received]
PHST- 2016/07/15 00:00 [accepted]
PHST- 2016/08/09 06:00 [entrez]
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2018/04/27 06:00 [medline]
PHST- 2016/08/08 00:00 [pmc-release]
AID - srep31165 [pii]
AID - 10.1038/srep31165 [doi]
PST - epublish
SO  - Sci Rep. 2016 Aug 8;6:31165. doi: 10.1038/srep31165.