PMID- 27498875
OWN - NLM
STAT- MEDLINE
DCOM- 20171113
LR  - 20171113
IS  - 2211-1247 (Electronic)
VI  - 16
IP  - 7
DP  - 2016 Aug 16
TI  - Distinct Roles of PKCiota/lambda and PKMzeta in the Initiation and Maintenance of 
      Hippocampal Long-Term Potentiation and Memory.
PG  - 1954-61
LID - S2211-1247(16)30948-2 [pii]
LID - 10.1016/j.celrep.2016.07.030 [doi]
AB  - PKMzeta has been proposed to be essential for maintenance of long-term potentiation 
      (LTP) and long-term memory (LTM). However, recent data from PKMzeta-knockout mice 
      has called this role into question. Instead, the other atypical isoform, protein 
      kinase C iota/lambda (PKCiota/lambda), has emerged as a potential alternative player. 
      Therefore, the nature of the "memory molecule" maintaining learned information 
      remains uncertain. Here, we report knockdown (KD) of PKCiota/lambda and PKMzeta in the 
      dorsal hippocampus and find deficits in early expression and late maintenance, 
      respectively, during both LTP and hippocampus-dependent LTM. Sequential increases 
      in the active form of PKCiota/lambda and PKMzeta are detected during LTP or fear 
      conditioning. Importantly, PKMzeta, but not PKCiota/lambda, KD disrupts previously 
      established LTM. Thus, PKCiota/lambda and PKMzeta have distinct functions in LTP and memory, 
      with PKMzeta playing a specific role in memory maintenance. This relaying pattern 
      may represent a precise molecular mechanism by which atypical PKCs regulate the 
      different stages of memory.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Wang, Shaoli
AU  - Wang S
AD  - The Key Laboratory of Developmental Genes and Human Disease, Institute of Life 
      Sciences, Southeast University, Nanjing, Jiangsu Province 210096, China; 
      Department of Neurobiology, Nanjing Medical University, Nanjing, Jiangsu Province 
      210029, China.
FAU - Sheng, Tao
AU  - Sheng T
AD  - The Key Laboratory of Developmental Genes and Human Disease, Institute of Life 
      Sciences, Southeast University, Nanjing, Jiangsu Province 210096, China; 
      Department of Neurobiology, Nanjing Medical University, Nanjing, Jiangsu Province 
      210029, China.
FAU - Ren, Siqiang
AU  - Ren S
AD  - Department of Neurobiology, Nanjing Medical University, Nanjing, Jiangsu Province 
      210029, China.
FAU - Tian, Tian
AU  - Tian T
AD  - Department of Neurobiology, Nanjing Medical University, Nanjing, Jiangsu Province 
      210029, China.
FAU - Lu, Wei
AU  - Lu W
AD  - The Key Laboratory of Developmental Genes and Human Disease, Institute of Life 
      Sciences, Southeast University, Nanjing, Jiangsu Province 210096, China; 
      Department of Neurobiology, Nanjing Medical University, Nanjing, Jiangsu Province 
      210029, China; Co-innovation Center of Neuroregeneration, Nantong University, 
      Nantong, Jiangsu Province 226001, China. Electronic address: luwei@seu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20160804
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (Isoenzymes)
RN  - 0 (Molecular Chaperones)
RN  - 0 (Prkcz protein, rat)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (enhanced green fluorescent protein)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - EC 2.7.11.13 (protein kinase C lambda)
SB  - IM
MH  - Animals
MH  - Fear/physiology
MH  - Gene Expression Regulation
MH  - Genes, Reporter
MH  - Green Fluorescent Proteins/genetics/metabolism
MH  - Hippocampus/anatomy & histology/*physiology
MH  - Isoenzymes/antagonists & inhibitors/*genetics/metabolism
MH  - Long-Term Potentiation/*genetics
MH  - Male
MH  - Memory, Long-Term/*physiology
MH  - Memory, Short-Term/*physiology
MH  - Microtomy
MH  - Molecular Chaperones/antagonists & inhibitors/*genetics/metabolism
MH  - Protein Kinase C/antagonists & inhibitors/*genetics/metabolism
MH  - RNA, Small Interfering/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
MH  - Tissue Culture Techniques
EDAT- 2016/08/09 06:00
MHDA- 2017/11/14 06:00
CRDT- 2016/08/09 06:00
PHST- 2016/05/04 00:00 [received]
PHST- 2016/06/21 00:00 [revised]
PHST- 2016/07/12 00:00 [accepted]
PHST- 2016/08/09 06:00 [entrez]
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2017/11/14 06:00 [medline]
AID - S2211-1247(16)30948-2 [pii]
AID - 10.1016/j.celrep.2016.07.030 [doi]
PST - ppublish
SO  - Cell Rep. 2016 Aug 16;16(7):1954-61. doi: 10.1016/j.celrep.2016.07.030. Epub 2016 
      Aug 4.