PMID- 27499107
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1463
DP  - 2016 Sep 9
TI  - Multi-residue determination of 210 drugs in pork by ultra-high-performance liquid 
      chromatography-tandem mass spectrometry.
PG  - 49-59
LID - S0021-9673(16)31029-9 [pii]
LID - 10.1016/j.chroma.2016.08.001 [doi]
AB  - This paper presents a multi-residue analytical method for 210 drugs in pork using 
      ultra-high-performance liquid chromatography-Q-Trap tandem mass spectrometry 
      (UPLC-MS/MS) within 20min via positive ESI in scheduled multi-reaction monitoring 
      (MRM) mode. The 210 drugs, belonging to 21 different chemical classes, included 
      macrolides, sulfonamides, tetracyclines, beta-lactams, beta-agonists, aminoglycosides, 
      antiviral drugs, glycosides, phenothiazine, protein anabolic hormones, 
      non-steroidal anti-inflammatory drugs (NSAIDs), quinolones, antifungal drugs, 
      corticosteroids, imidazoles, piperidines, piperazidines, insecticides, amides, 
      alkaloids and others. A rapid and simple preparation method was applied to 
      process the animal tissues, including solvent extraction with an 
      acetonitrile/water mixture (80/20, v/v), defatting and clean-up processes. The 
      recoveries ranged from 52% to 130% with relative standard deviations (RSDs)<20% 
      for spiked concentrations of 10, 50 and 250mug/kg. More than 90% of the analytes 
      achieved low limits of quantification (LOQs)<10mug/kg. The decision limit (CCalpha), 
      detection capability (CCbeta) values were in the range of 2-502mug/kg and 4-505mug/kg, 
      respectively. This method is significant for food safety monitoring and 
      controlling veterinary drug use.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Yin, Zhiqiang
AU  - Yin Z
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Key 
      Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural 
      Sciences; Key Laboratory of Agri-Food Quality and Safety, Ministry of 
      Agriculture, Beijing 100081, China.
FAU - Chai, Tingting
AU  - Chai T
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Key 
      Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural 
      Sciences; Key Laboratory of Agri-Food Quality and Safety, Ministry of 
      Agriculture, Beijing 100081, China.
FAU - Mu, Pengqian
AU  - Mu P
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Key 
      Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural 
      Sciences; Key Laboratory of Agri-Food Quality and Safety, Ministry of 
      Agriculture, Beijing 100081, China.
FAU - Xu, Nana
AU  - Xu N
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Key 
      Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural 
      Sciences; Key Laboratory of Agri-Food Quality and Safety, Ministry of 
      Agriculture, Beijing 100081, China.
FAU - Song, Yue
AU  - Song Y
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Key 
      Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural 
      Sciences; Key Laboratory of Agri-Food Quality and Safety, Ministry of 
      Agriculture, Beijing 100081, China.
FAU - Wang, Xinlu
AU  - Wang X
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Key 
      Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural 
      Sciences; Key Laboratory of Agri-Food Quality and Safety, Ministry of 
      Agriculture, Beijing 100081, China.
FAU - Jia, Qi
AU  - Jia Q
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Key 
      Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural 
      Sciences; Key Laboratory of Agri-Food Quality and Safety, Ministry of 
      Agriculture, Beijing 100081, China.
FAU - Qiu, Jing
AU  - Qiu J
AD  - Institute of Quality Standards and Testing Technology for Agro-Products, Key 
      Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural 
      Sciences; Key Laboratory of Agri-Food Quality and Safety, Ministry of 
      Agriculture, Beijing 100081, China. Electronic address: qiujing@caas.cn.
LA  - eng
PT  - Journal Article
DEP - 20160802
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Veterinary Drugs)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Drug Residues/*analysis
MH  - Humans
MH  - Limit of Detection
MH  - Red Meat/*analysis
MH  - *Swine
MH  - Tandem Mass Spectrometry/*methods
MH  - Time Factors
MH  - Veterinary Drugs/*analysis
OTO - NOTNLM
OT  - Q-Trap
OT  - Residue
OT  - Screening
OT  - UPLC-MS/MS
OT  - Veterinary drugs
EDAT- 2016/08/09 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/08/09 06:00
PHST- 2016/03/25 00:00 [received]
PHST- 2016/07/28 00:00 [revised]
PHST- 2016/08/01 00:00 [accepted]
PHST- 2016/08/09 06:00 [entrez]
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0021-9673(16)31029-9 [pii]
AID - 10.1016/j.chroma.2016.08.001 [doi]
PST - ppublish
SO  - J Chromatogr A. 2016 Sep 9;1463:49-59. doi: 10.1016/j.chroma.2016.08.001. Epub 
      2016 Aug 2.