PMID- 27501281
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20220408
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 101
IP  - 10
DP  - 2016 Oct
TI  - Circulating and Adipose Levels of Adipokines Associated With Insulin Sensitivity 
      in Nonobese Subjects With Type 2 Diabetes.
PG  - 3765-3771
AB  - CONTEXT: The adipokines chemerin, dipeptidyl peptidase 4, and adiponectin 
      influence insulin sensitivity. Whether their circulating levels and adipose 
      secretion are altered in nonobese individuals with type 2 diabetes mellitus 
      (T2DM) is unknown. OBJECTIVE: The objective of this study was to investigate SC 
      adipose secretion and serum levels of the three adipokines in relation to T2DM 
      features. DESIGN: Fourteen nonobese T2DM and 13 healthy men were investigated. 
      Insulin sensitivity and glucose control were assessed by hyperinsulinemic 
      euglycemic clamp, homeostasis model assessment, and glycated hemoglobin. MAIN 
      OUTCOME MEASURE: Association of circulating and adipose-secreted adipokines with 
      fat cell volume and insulin sensitivity was measured. PARTICIPANTS: Volunteers in 
      an outpatient academic clinic participated. RESULTS: Although adipose secretion 
      was similar between the groups, serum chemerin was higher (70 +/- 10 vs 50 +/- 1 
      ng/ml; P = .005), adiponectin lower (4.7 +/- 1.3 vs 6.8 +/- 2.2 mug/ml; P = .005), and 
      dipeptidyl peptidase 4 unaltered in T2DM. Serum adiponectin (r = 0.53; P = .005) 
      and chemerin (r = -0.42; P = .03) correlated with adipose secreted levels. 
      Secreted and circulating chemerin correlated positively with adipocyte volume (r 
      > 0.40; P < .05), whereas serum adiponectin correlated negatively with this 
      measure (r = -0.61; P = .001). Adiponectin serum half-life was decreased in T2DM 
      (168 +/- 24 vs 186 +/- 18 minutes; P = .029) and correlated negatively with glycated 
      hemoglobin (r = -0.45; P = .03) and adipocyte volume (r = -0.56; P < .003). Serum 
      adiponectin (r = 0.57; P = .017) and chemerin (r = -0.52; P = .03) associated 
      with clamp measures independently of T2DM diagnosis. CONCLUSIONS: In nonobese 
      men, circulating adiponectin and chemerin levels are altered in T2DM without 
      changes in adipose secretion. Adipocyte volume is important for variations in 
      serum chemerin and adiponectin and for serum clearance of adiponectin. In T2DM, 
      poor glucose control also plays a role for adiponectin clearance.
FAU - Andersson, Daniel P
AU  - Andersson DP
AD  - Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
FAU - Laurencikiene, Jurga
AU  - Laurencikiene J
AD  - Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
FAU - Acosta, Juan R
AU  - Acosta JR
AD  - Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
FAU - Ryden, Mikael
AU  - Ryden M
AD  - Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
FAU - Arner, Peter
AU  - Arner P
AD  - Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20160808
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Chemokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (RARRES2 protein, human)
RN  - EC 3.4.14.5 (Dipeptidyl Peptidase 4)
SB  - IM
MH  - Abdominal Fat/*metabolism
MH  - Adipocytes
MH  - Adiponectin/blood/*metabolism
MH  - Adult
MH  - Aged
MH  - Chemokines/blood/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/*metabolism
MH  - Dipeptidyl Peptidase 4/blood/*metabolism
MH  - Humans
MH  - *Insulin Resistance
MH  - Intercellular Signaling Peptides and Proteins/blood/*metabolism
MH  - Intra-Abdominal Fat/*metabolism
MH  - Male
MH  - Middle Aged
PMC - PMC5052350
EDAT- 2016/08/09 06:00
MHDA- 2017/07/01 06:00
PMCR- 2016/08/08
CRDT- 2016/08/09 06:00
PHST- 2016/08/09 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2016/08/09 06:00 [entrez]
PHST- 2016/08/08 00:00 [pmc-release]
AID - 16-1883 [pii]
AID - 10.1210/jc.2016-1883 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2016 Oct;101(10):3765-3771. doi: 10.1210/jc.2016-1883. 
      Epub 2016 Aug 8.